PLCG2 signaling and genetic resilience in Alzheimer’s disease - Molecular Neurodegeneration Molecular Neurodegeneration - Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and pathological hallmarks, including amyloid plaques,...

#PLCG2 signaling and genetic resilience in #AlzheimersDisease

Andy P. Tsai, Amara K. Martin, Andrew Mi, Ava E. Yeh, Eduardo Ramirez Lopez, Tony Wyss-Coray #microglia

link.springer.com/article/10.1...

Go go go submit a symposium proposal for #NeuroFrance2027!

And let’s make sure glial cells get the spotlight they deserve.
#Astrocytes, #microglia, #oligodendrocytes

Submit your proposal before 24 April 2026 👇

#glia #neuroscience #Bordeaux

We’re excited to welcome Lisa Huis in ’t Veld as a new Social Media Ambassador!
A postdoc at Charité Berlin, she studies interferon signaling and USP18 in microglia after viral infection.
Passionate about glial research, Lisa aims to spark dialogue across labs worldwide.
Welcome, Lisa!

#Microglia

The @martinfuhrmann.bsky.social Lab ( #DZNE) at #BonnBrain26:

#Microglial Ca-dynamics (Eyberg, A44)
NE-modulated #microglia (Antony, A45)
#Stress-driven #synapse remodeling (Crux, A46)
#Actin control of microglia (Hoffmann, A47)
#Odor coding in #SNNs (myself, A11)

Stop by our posters today 👌

Some papers stand out from the rest. After Evelyne's passing, we all felt a strong desire to complete this project in her honour. It's more than just a paper; it's a tribute to her memory and her passion for retinal wave
#retina #microglia #retinalwaves #development

www.biorxiv.org/content/10.6...

Glioblastoma brain tumors hijack sugar metabolism to evade immune attack – BioNews Central Study finds immune cells in glioblastoma use fructose to evade immune response, pointing to a new treatment target. ...

Study finds #ImmuneCells in #glioblastoma use #fructose to evade #ImmuneResponse, pointing to a new #TreatmentTarget.
#BrainCancer #Microglia #ImmuneEvasion

UK Glia 2026 UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...

Late breaking abstracts- posters only!

Don't miss the opportunity to see the mighty Bal Khakh FRS
He is entertaining, British and returning to the UK to bring his brilliance to the @ukdri.ac.uk

#neuroscience #glia #astroctyes #microglia #oligodendrocytes #myelin

www.physoc.org/events/uk-gl...

Researchers Identify How Lecanemab Activates Microglia to Clear Alzheimer’s Plaques Researchers at the Vlaams Instituut voor Biotechnologie (VIB) and KU Leuven have uncovered the mechanism by which the Alzheimer’s drug lecanemab, marketed as Leqembi, works in the brain. The study reveals that the drug’s effectiveness relies on a specific part of the antibody called the Fc fragment. This fragment acts as a trigger for microglia, the brain’s immune cells, prompting them to clear toxic amyloid plaques associated with Alzheimer's disease. Previous uncertainty about the drug’s mechanism has now been resolved, demonstrating that without the Fc fragment, microglia remain inactive and plaque clearance does not occur. Using a mouse model containing human microglial cells, researchers observed that activated microglia remove plaques through processes such as phagocytosis and lysosomal activity, with gene activity patterns, including the expression of SPP1, correlating with effective plaque clearance. The findings suggest new strategies for Alzheimer’s treatments, potentially allowing future therapies to activate microglia directly, without relying on antibodies. The study was published in Nature Neuroscience and funded by several organizations including the European Research Council and the Alzheimer’s Association.

Researchers Identify How Lecanemab Activates Microglia to Clear Alzheimer’s Plaques

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

#alzheimers #lecanemab #microglia

View full AI summary:

Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis The hypothalamic-pituitary-gonadal axis (HPG) controls pubertal development, sexual maturation, and fertility. We identified a role of hypothalamic microglia in controlling the HPG axis through recept...

This is a rather surprising finding!

#Microglia Rank signaling regulates GnRH #neuronal function and the #hypothalamic - #pituitary - #gonadal axis | Science www.science.org/doi/10.1126/...

🧠 AAV11: Precision Tool for Microglia Research 🔬

Efficient, microglia-specific gene delivery across brain & spinal cord. Perfect for detailed microglia labeling. 🌟

Collab? kz.lin@siat.ac.cn | BD@ebraincase.com
www.ebraincase.com/support/lite...

#AAV11 #Microglia #Neuroscience #GeneDelivery

The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial - Nature Medicine In this phase 2, randomized trial in early Alzheimer’s disease, the TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical Dementia Rating-Sum of Boxes score.

In this phase 2, randomized trial in early #Alzheimers disease, the #TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical Dementia Rating-Sum of Boxes. #microglia #AD
https://www.nature.com/articles/s41591-026-04273-1

PU.1: the conductor of #Alzheimers symphony

Chunli Sun & Qianjin Liu #microglia

link.springer.com/article/10.1...

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline - Aging-US Research As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels.

✅ Read our #blog post about the #research paper, titled "Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age."

#Summary ⬇️
aging-us.org/2025/06/oxyg...

#aging #trendingwithimpact #brain #microglia #endothelial #oa #peerreview #publishing

Online now: Comparisons in microglial responses to ischemic–hypoxic #braininjury in neonatal and adult mice analyzed by transcriptome integration and deconvolution #technologies. doi.org/10.4103/ATN.... #Microglia #Neuroinflammation #Transcriptomics #SingleCell #StrokeResearch #MedSky #neuroskyence

🔎 Je #hersenen hebben verschillende soorten cellen, zoals #microglia. Overal waar problemen zijn in de hersenen, komen microgliacellen om deze op te lossen.

1 month left to submit your #Glia2027 symposium proposal!

Deadline: 8 April 2026, 12:00 p.m. CEST
Submit here: http://www.glia-meeting.eu

Join us in Bologna, Italy (7–10 Jul 2027) and shape the future of glial research!

#GlialCells #Astrocytes #Oligodendrocytes #Microglia #SchwannCells

Female-specific Cx3cr1-driven regulation of #ALS and #Alzheimer’s risk genes in #tauopathy

Ari Sudwarts & Gopal Thinakaran @thinakaran.bsky.social #microglia #transcriptome

link.springer.com/article/10.1...

Cover image from Trends in Neurosciences showing immunohistochemistry of microglia with phagolysosomes.

New cover alert! 🧠✨
Our review in Trends in Neurosciences @cp-trendsneuro.bsky.social is out. Laura Fonken and I explore how phagocytosis – cellular debris clearance – is a pivotal switch for brain inflammation.

authors.elsevier.com/a/1mi1vbotqB...
#Neuroscience #Microglia #Neurotrauma #ScienceSky

Microglia Research Summary February 2026 - Summarized Science Summary of key Microglia publications highlighting major findings, clinical relevance, and emerging research trends.

🧫 Microglia - Feb 2026

• BTK inhibition reduces neuroinflammation in ALS models
• Microglia-T cell interactions drive neurodegeneration in Huntington's
• TGF-β inhibition in microglia stimulates adult neurogenesis

pir.sh/JoZa0Nr1Gy

#Microglia #Neuroinflammation

🧠 𝐈𝐧𝐭𝐞𝐫𝐠𝐥𝐢𝐚𝐥 𝐂𝐫𝐨𝐬𝐬𝐭𝐚𝐥𝐤 & 𝐍𝐞𝐮𝐫𝐨𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐢𝐨𝐧 🧪

Microglia and astrocytes communicate to drive—or delay—disease progression. New research highlights this signaling as a major therapeutic target for neurological disorders.

🔗 Read More: https://lnkd.in/dmHDEDeD

#NeuroSky #Microglia #Neuroscience #CNS

The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial - Nature Medicine In this phase 2, randomized trial in early Alzheimer’s disease, the TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical Dementia Rating-Sum of Boxes score.

In this phase 2, randomized trial in early #Alzheimers disease, the #TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical Dementia Rating-Sum of Boxes. #microglia #AD
https://www.nature.com/articles/s41591-026-04273-1

#AIGS26 | Day 1 (Sept 16) 🧠

Session 2: "New Insights on Glial Cells in Neurodegeneration: A Focus on Metabolism".

Speakers:
🔬 Alberto Pascual @ibis-investigacion.bsky.social #microglia #metabolism
🔬 Maite Solas @unav.edu #astrocytes #alzheimers
🔬 Vanja @tepavcevicvanja.bsky.social #myelin #MS

Achucarro Glia School 2026 - Achucarro Basque Center for Neuroscience NOTICE FOR THIS EDITION The Organisation will select participants among the candidates who correctly complete the (pre)Application Form (check the right column). Candidates commit to paying the tuitio...

#AIGS26 | Day 1 (Sept 16) 🧠

Session 1: "Understanding Glial Cells: Cellular Breakthroughs".

Speakers:
🔬 Amanda Sierra @sierralab.bsky.social #microglia #phagocytosis
🔬 Juan Pedro Bolaños @bolanosjuanp.bsky.social #metabolism #mitochondria
🔬 Arne Battefeld #oligodendrocytes #signaling

The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial - Nature Medicine In this phase 2, randomized trial in early Alzheimer’s disease, the TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical De...

Results from the #INVOKE2 phase 2 trial of the #TREM2 agonistic #antibody #AL002 in early #Alzheimers disease out now. Although #AL002 showed target engagement, no change in CDR-SB was seen. #microglia #dementia #AD
www.nature.com/articles/s41...

Massimo Pandolfo and Stefano Stifani

Congratulations to researchers Stefano Stifani and Massimo Pandolfo, who have been awarded US$250,000 by the Friedreich’s Ataxia Research Alliance for their project studying how #microglia contribute to neuroinflammation in Friedreich’s #ataxia.

www.curefa.org/funded-grant...

We’re thrilled to welcome Sarah Tarhini as the newest member of our Social Media Ambassador series!
A neuroscientist studying microglia, maternal immunity & CMV-related neurodevelopment, Sarah also champions inclusive, accessible science.
Welcome, Sarah!

#Microglia #InclusiveScience

Microglia surveillance is directed toward neuron activation during sustained intracortical microstimulation Microglia surveillance is directed toward neuron activation during sustained intracortical microstimulation, Preszler, Colin, Stieger, Kevin C, Chen, Keying, Zhang, Guangfeng, Kozai, Takashi D Y

Funded by your NIH & NSF dollars, exactly the kind of early-stage, curiosity-driven research private sectors skip. Federal investment builds the knowledge base for tomorrow's therapies.
Open access paper: iopscience.iop.org/article/10.1...

#Neuroprosthetics #Microglia #OpenAccess

Swapping old immune cells in the brain with fresh ones could treat disease Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.

Short extracts from my @Nature News interview of several months ago on #microglia #replacement for brain diseases. Recent advances in grafting, conditioning & cell engineering boost replacement in preclinical studies, and clinical data highlight its promise www.nature.com/articles/d41...

Achucarro International Glia School is back! #AIGS26

Registration period is already open, and the final programme accessible.

Looking forward to this edition in #Plentzia

www.achucarro.org/gl...

#astrocytes #microglia #oligodendrocytes #glialcells

¿Tumores que frenan el Alzheimer? La pista: cistatina C Cáncer y Alzheimer, conectados por una proteína: cistatina C cruza al cerebro, activa TREM2 y reduce amiloide en ratones en vivo, según Cell. En un trabajo publicado en Cell y firmado por un equipo de...

¿Tumores que frenan el Alzheimer? La pista: cistatina C #Alzheimer #Cancer #Neurociencia #Investigacion #Ciencia #Salud #Demencia #TREM2 #Microglia #CistatinaC #Cell #Medicina #26defebrero #felizjueves donporque.com/tumores-que-...