This review highlights #MYC as a central #oncogenic driver in #cancer, regulating proliferation, and #ImmuneEvasion, while exploring strategies to target MYC via MYC–MAX disruption, transcriptional control and synthetic lethal pathways.

#OpenAccess: doi.org/10.1016/j.ge...

This #STTT review outlines #ImmuneEvasion mechanisms in #Cancer, including checkpoint activation and #TumorMicroenvironment-mediated suppression, and discusses emerging therapeutic approaches for enhancing anti-tumor immunity.

#OpenAccess: doi.org/10.1038/s413...

Glioblastoma brain tumors hijack sugar metabolism to evade immune attack – BioNews Central Study finds immune cells in glioblastoma use fructose to evade immune response, pointing to a new treatment target. ...

Study finds #ImmuneCells in #glioblastoma use #fructose to evade #ImmuneResponse, pointing to a new #TreatmentTarget.
#BrainCancer #Microglia #ImmuneEvasion

SMLR1 engages TAM markers MRC1 (CD206) & SIGLEC1 (CD169), linking metastatic CRC cells to immunosuppressive macrophages in the liver niche.
A potential immune-evasion mechanism in CRLM.

CHP 2024;1(1):0003
#TumorPlasticity #ImmuneEvasion

This #STTT study reveals that #ExtracellularVesicle-derived #miRNA1825p induces an #Immunosuppressive macrophage phenotype in #PancreaticCancer, identifying a key mechanism of #ImmuneEvasion and a novel #TherapeuticTarget. #Medsky

#OpenAccess: doi.org/10.1038/s413...

Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer

This #STTT study identified IGF2BP1 as a central mediator of #ImmuneEvasion in C5-subtype high-grade serous #OvarianCancer, demonstrating that IGF2BP1 inhibition synergizes with PD-1 blockade to overcome immune evasion. @unihalle.bsky.social
#OpenAccess: doi.org/10.1038/s413...

An overview of circRNAs in HBV-induced #HCC, delineating their roles as critical regulators of oncogenic signaling & #ImmuneEvasion while evaluating their potential as #Biomarkers and #TherapeuticTargets in #LiverCancer.

#OpenAccess: doi.org/10.1016/j.ge...

STAT5-activating oncogenes-induced oncostatin M (OSM) expression promotes #ImmuneEvasion and disease progression, establishing OSM signaling as a promising #TherapeuticTarget for myeloproliferative #Neoplasms.

#STTT #OpenAccess: doi.org/10.1038/s413...

By mapping the metabolic-#Epigenetic-immune axis, this review identifies how the interplay of nutrient competition and #ChromatinRemodeling drives cancer plasticity and #ImmuneEvasion, offering new multitargeted therapeutic strategies.

#STTT #OpenAccess: doi.org/10.1038/s413...

This #STTT review synthesizes the “metabolic-#Epigenetic-immune axis” to show how metabolic-driven #ChromatinRemodeling fuels #ImmuneEvasion, identifying nodal convergence points for next-gen multi-target precision oncology.

#OpenAccess: doi.org/10.1038/s413...

Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer

Thrilled to highlight our cover & cover article in #STTT, revealing IGF2BP1 as a key #ImmuneEvasion driver in C5-HGSC and showing that RBP inhibition boosts antigen presentation and sensitizes tumors to PD-1 blockade. @unihalle.bsky.social

Read: doi.org/10.1038/s413...

#CancerScience #BioResearch

FAM114A1 promotes #TNBC #ImmuneEvasion by suppressing tumor antigen presentation via activation of the PI3K/AKT pathway and subsequent E2F4-driven MTDH transcription. #Medsky @princeton.edu @rutgerscancer.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Oligomeric #cystatinC binds LILRB2/LILRB5 on myeloid cells, enhancing #TcellSuppression and #tumor progression via phosphatase and TGF-β signaling. CST3 loss impairs growth, underscoring amyloid–LILRB as a novel #ImmuneEvasion axis.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Online today -> A viral glycoprotein targets IgG+ memory #Bcells to mediate humoral #ImmuneEvasion

by P. Cramer, M. Rizzi, H. Hengel and colleagues @uni-freiburg.de @univie.ac.at
🗞️ doi.org/10.1038/s443...

Researchers identify a mechanism of immune evasion employed by melanoma cancer cells – BioNews Central A new international study reveals how melanoma cancer cells evade the immune system by secreting extracellular vesicles. ...

A new international study reveals how #melanoma #CancerCells evade the #ImmuneSystem by secreting #ExtracellularVesicles.
#ImmuneEvasion

Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer

Scientists identify #IGF2BP1 as a driver of #ImmuneEvasion in C5 #OvarianCancer, suppressing IFN‑γ–IRF1–MHC‑I signaling and T‑cell infiltration; its inhibition restores #antitumor immunity and boosts #PD1blockade. @unihalle.bsky.social

#OpenAccess in #STTT: doi.org/10.1038/s413...

Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer

Scientists identify #Dysadherin as an upstream activator of the FAK/YAP/TEAD2 axis in #HCC, showing it drives #CancerStemness and #ImmuneEvasion, while genetic or peptide inhibition restores #antitumor immunity and improves therapy response.

#OpenAccess #STTT: doi.org/10.1038/s413...

#ACAT1 acquires a nuclear role in #ColorectalCancer, where S60 phosphorylation enables p50 acetylation, relieves #NFκB repression, enhances #NKcell recruitment, while nutrient stress blocks this axis and drives #ImmuneEvasion and poor prognosis.

#STTT: doi.org/10.1038/s413...

A bio-barrier-adaptable #Biomimetic #Nanoplatform, MSF@CCM, exhibits enhanced #TumorAccumulation & #ImmuneEvasion along with amplified ultrasound-mediated intratumoral penetration, highlighting it as a promising modality for #CancerTherapy.

#OpenAccess: doi.org/10.1038/s413...

A molecular ‘safety switch’ shields cancers from immune attack – BioNews Central A large genetic screen identified the TAK1 gene as a protective switch in cancer cells that helps them survive attacks from killer T cells, potentially reducing the effectiveness of immunotherapy treatments. ...

A large #GeneticScreen identified the TAK1 gene as a protective switch in #CancerCells that helps them survive #ImmuneAttack, potentially reducing the effectiveness of #immunotherapy treatments.
#AntiCancerImmunity #ImmuneEvasion 

🔦 Have you seen our latest Commentary?

TREX1, a predator for treating MSI-H tumors?

🔓 buff.ly/MAOG3pB

#cGASSTING #ImmuneEvasion #CancerResearch

A comprehensive look at the molecular tricks tumors use to evade immunity—and the cutting-edge therapies designed to counter them.
#ImmuneEvasion #CancerImmunity #TumorMicroenvironment #Immunotherapy
www.nature.com/articles/s41...

The Trojan Horse Within: Mechanisms of Immune Evasion in Breast Cancer The Trojan Horse Within: Mechanisms of Immune Evasion in Breast Cancer

📢 We review the mechanisms of immune evasion in breast cancer, focusing on how cellular plasticity and the tumor immune microenvironment cooperate to suppress detection. 🧬
@chp-pivot.bsky.social
www.pivotscipub.com/chp/3/1/0001...
#breastcancer #ImmuneEvasion #TumorMicroenvironment #CellPlasticity

FAM114A1 drives #ImmuneEvasion & ICB resistance in #TNBC by activating PI3K/AKT and boosting E2F4/MTDH signaling, thus impairing antigen presentation. #medsky @princeton.edu @rutgerscancer.bsky.social @fudan-university.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Scientists decipher #PDAC immune evolution at single-cell resolution, revealing direct tumor-induced #dendriticcells #apoptosis via the ANXA1-FPR1/3 axis and illuminating #ImmuneEvasion mechanisms and therapeutic targets. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

U01.03.013 Bacterial virulence factor Bacterial virulence factors are specialized molecules or structures that enable bacteria to colonize hosts, evade immune responses, and cause disease. These include capsules, toxins, adhesins, enzymes, and secretion systems that enhance pathogenicity and determine disease severity.

Learn key bacterial virulence factors and their role in infection and immune evasion. #BacterialVirulence #VirulenceFactors #Microbiology #Pathogenesis #Toxins #Capsules #Adhesins #Enzymes #SecretionSystems #USMLE #MedicalEducation #ClinicalMicrobiology #ImmuneEvasion #BacterialPathogens

New antibody therapy reawakens immune system to fight pancreatic cancer – BioNews Central Study reveals how pancreatic cancer tumors evade immunity using a sugar disguise, and how a new antibody therapy restores immunity in mice. ...

Study reveals how #PancreaticCancer #tumors evade #immunity using a sugar disguise, and how a new #AntibodyTherapy restores immunity in mice.
#ImmuneEvasion #TherapyResistance

This review highlights the multifaceted mechanisms of #tumor #ImmuneEvasion, including checkpoint regulation, #TumorMicroenvironment dynamics & #MetabolicReprogramming, while discussing emerging #immunotherapies to curb resistance.

#STTT #OpenAccess: doi.org/10.1038/s413...

This study uses an ABE-based #sgRNA library to map over 1,000 functional #mutations that regulate PD-L1 and HLA-I expression, identifying SETD2_Y1666, which influences #ImmuneEvasion & anti-PD-1/PD-L1 therapy responses. @pku1898.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Lung cancer rewires immune cells in the bone marrow to weaken body’s defenses – BioNews Central New research shows lung cancer weakens the immune system by reprogramming bone marrow immune cells before they reach tumors, suggesting a potential target to improve immunotherapy. ...

New research shows #LungCancer weakens the #ImmuneSystem by reprogramming #BoneMarrow #ImmuneCells before they reach tumors, suggesting a potential target to improve #immunotherapy.
#ImmuneEvasion