A #MonoclonalAntibody targeting mutant p53‑R175H shows high #antitumor activity, with enhanced efficacy when combined with anti‑PD‑1, highlighting DNA‑delivered antibodies as a strategy for #mutantp53‑driven #cancers. @bcmhouston.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
#Bcl6 inhibition destabilizes #TregCells by reducing H3K4me3, enhancing #AntiTumor immunity, delaying #HeadandNeckSquamousCellCarcinoma progression, and synergizing with immune checkpoint therapy, highlighting Bcl6 as a promising target.
#OpenAccess: doi.org/10.1016/j.ge...
Researchers from @uclacollege.bsky.social use spatiotemporal analyses to compare the #AntiTumor response of CAR-T & CAR-NKT cells in #SolidTumors, revealing differences in immune-cell dynamics, tumor infiltration, and checkpoint regulation.
#OpenAccess: doi.org/10.1038/s413...
❓Tech Q&A | Niraparib HCl has #antitumor activity and shows some cytotoxicity
🔸At appropriate concentrations, it typically does not add extra toxicity to normal cells
🔸Can be used directly as a #PARP inhibitor after dissolution, no desalting required
#PARPInhibitor #CancerResearch #CellBiology
#Article in #MedComm
A Novel #Peptide, #HS1002, Enhances #Antitumor Activity via Dual Targeting of the #GnRH Receptor and Human #Telomerase Reverse Transcriptase in Prostate Cancer Cells doi.org/10.1002/mco2...
Research team from Sungkyunkwan University
#hTERT #ImmuneResponse #ProstateCancer
Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients
This study shows that #HBOTherapy exerts #Antitumor effects in #Glioblastoma, promoting #Apoptosis, inhibiting #Inflammation, reducing #CellProliferation, suppressing #TumorGrowth & #Metastasis, regulating #Vascularization, & thus prolonging patient survival. #medsky
Read: doi.org/10.1007/s115...
A bimetallic triple-kill nanobomb system (MnO₂/Co-DA@BiTE/HPT) synergistically enhances BiTE efficacy against #ColorectalCancer by activating the STING pathway via #PhotothermalTherapy, to promote robust #AntiTumor immunity.
#STTT #OpenAccess: doi.org/10.1038/s413...
Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
In this study, the researchers spotlight the #Antitumor potential of variant 7 among synthesized pyrrolidone compounds in #DLBCL cell lines, which induces #DNAdamage, #Inflammatory responses, #CellCycle arrest, & #Apoptosis. #medsky
To read: doi.org/10.1007/s115...
CXCR4hi #CARTcells boost #TumorTracking, #BoneMarrow homing, and persistence, enhancing #Antitumor activity; early trial data in B cell malignancies show multiple complete responses, supporting #CXCR4 modification.
#OpenAccess in #STTT: doi.org/10.1038/s413...
🗝️ Tor und 🏰 Schlüssel zur Wirkung von 🌱 #Cannabis 06
mastodon.social/@Karl_Theodor/1161308336...
#Immunsystem #antiTumor #cancer #Krebs #hanf #hemp #marijuana #Hanf_heilt #Hanfwissen #healing #health #Gesundheit #Medizin #Wissenschaft #Forschung
Anti-MSLN chimeric antigen receptor-like NK cell therapy with tumor-penetrating capacity (uCAR-like NK) for solid tumors
Anti-mesothelin uCAR-like #NaturalKiller cells integrating #tumor-penetrating #peptides show enhanced targeting, infiltration, & superior #antitumor efficacy, establishing a modular nongenetic NK platform for MSLN-positive #SolidTumorTherapy.
#OpenAccess #STTT: doi.org/10.1038/s413...
SHR-1701 plus nab-paclitaxel and #gemcitabine show promising #antitumor activity with manageable safety in advanced #PancreaticCancer, while PD-L1 status and #biomarkers such as CA19-9 predict improved survival outcomes. @fudan-university.bsky.social
#STTT: doi.org/10.1038/s413...
Scientists show that engineering #CARTcells to overexpress #CXCR4 restores #CXCL12-guided migration, enhances #tumortracking and #BoneMarrow homing, promotes memory persistence, and improves #antitumor efficacy in #BcellLymphoma and #myeloma.
#STTT: doi.org/10.1038/s413...
HSD17B12 interacts with PD-L1 in living cells.Top: PD-L1 partially colocalizes with HSD17B12 in A375 cells. Representative images are shown (scale bars: 5 μm). Immunofluorescence staining was performed using anti-PD-L1 and anti-HSD17B12 antibodies. Bottom: Schematic model showing membrane localization of HSD17B12.
#Cancer #immunotherapy faces widespread resistance via mechanisms like PD-L1 suppression. This study identifies the metabolic enzyme HSD17B12 as a regulator of PD-L1 degradation, showing that an HSD17B12-derived peptide boosts #AntiTumor #immunity in a mouse model @plosbiology.org 🧪 plos.io/4k2rtyR
HSD17B12 interacts with PD-L1 in living cells.Top: PD-L1 partially colocalizes with HSD17B12 in A375 cells. Representative images are shown (scale bars: 5 μm). Immunofluorescence staining was performed using anti-PD-L1 and anti-HSD17B12 antibodies. Bottom: Schematic model showing membrane localization of HSD17B12.
#Cancer #immunotherapy faces widespread resistance via mechanisms like PD-L1 suppression. This study identifies the metabolic enzyme HSD17B12 as a regulator of PD-L1 degradation, showing that an HSD17B12-derived peptide boosts #AntiTumor #immunity in a mouse model @plosbiology.org 🧪 plos.io/4k2rtyR
HSD17B12 interacts with PD-L1 in living cells.Top: PD-L1 partially colocalizes with HSD17B12 in A375 cells. Representative images are shown (scale bars: 5 μm). Immunofluorescence staining was performed using anti-PD-L1 and anti-HSD17B12 antibodies. Bottom: Schematic model showing membrane localization of HSD17B12.
#Cancer #immunotherapy faces widespread resistance via mechanisms like PD-L1 suppression. This study identifies the metabolic enzyme HSD17B12 as a regulator of PD-L1 degradation, showing that an HSD17B12-derived peptide boosts #AntiTumor #immunity in a mouse model @plosbiology.org 🧪 plos.io/4k2rtyR
An open-label, single-arm, phase II #ClinicalTrial assessing the efficacy of #Sintilimab + #Anlotinib revealed promising #AntiTumor effect and safety profile in treatment-naïve #Metastatic #ColorectalCancer (mCRC) patients.
#OpenAccess: doi.org/10.1038/s413...
New publication: "Trastuzumab-Conjugated pH-Sensitive Micelles Exhibit #Antitumor Activity and Induce Mesenchymal-to-Epithelial Transition in Triple-Negative Breast #Cancer Cell Lines" with Kirsten Sandvig from @biovitenskap.bsky.social , published in #Pharmaceutics by @mdpiopenaccess.bsky.social
📰New & Featured | #Cell: #GPX4 released during #ferroptosis binds to dendritic #ZP3, activating cAMP-PPKA signaling
🔸Inhibits #glycolysis
🔸Impairs DC maturation and activation
🔸Eventually results in T cell priming defect
🧐Blocking GPX4-ZP3 interaction potentially drives #antitumor activity
Researchers develop a #PSMA‑targeted self‑assembling nano‑PROTAC that simultaneously degrades AR, AR‑V7, and HSP90 in #CRPC, overcoming resistance to AR inhibitors, achieving potent #antitumor activity with tumor‑specific accumulation.
#OpenAccess in #STTT: doi.org/10.1038/s413...
Scientists identify #IGF2BP1 as a driver of #ImmuneEvasion in C5 #OvarianCancer, suppressing IFN‑γ–IRF1–MHC‑I signaling and T‑cell infiltration; its inhibition restores #antitumor immunity and boosts #PD1blockade. @unihalle.bsky.social
#OpenAccess in #STTT: doi.org/10.1038/s413...
Scientists identify #Dysadherin as an upstream activator of the FAK/YAP/TEAD2 axis in #HCC, showing it drives #CancerStemness and #ImmuneEvasion, while genetic or peptide inhibition restores #antitumor immunity and improves therapy response.
#OpenAccess #STTT: doi.org/10.1038/s413...
#Letter in #MedComm
Non-stoichiometric Sodium Chloride Reprograms Ionic Homeostasis to Enhance Antitumor Immunity doi.org/10.1002/mco2...
#TME #DendriticCell #ExtracellularPotassium #Ionic #Homeostasis #Antitumor #Immunity
A review on the #AntiTumor mechanisms of high-dose #VitaminC, detailing preclinical & clinical studies investigating its #AntiCancer role, advancements in high-dose vitamin C therapy for #Cancer treatment, and directions for future research.
#OpenAccess: doi.org/10.1016/j.ge...
An open-label, single-arm, phase II #ClinicalTrial of #Sintilimab + #Anlotinib in treatment-naïve #Metastatic #ColorectalCancer patients showed promising #Antitumor efficacy & a tolerable safety profile.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Neutrophil-targeted #STAT3 inhibition reshapes #neutrophils into #antitumor effectors, suppresses tumor growth, and boosts cytotoxic CD8⁺ T-cell activity, highlighting STAT3 blockade as a promising #CancerImmunotherapy strategy. @unidue.bsky.social
#STTT: doi.org/10.1038/s413...
EpsteinBarrVirus upregulates KDM5B via EBNA1 and BZLF1, driving #EpithelialCancer progression through PLK2 demethylation and PI3K/AKT/mTOR activation, while KDM5B inhibition delivers strong #AntiTumor effects. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
Join us next week for an episode with Dr. Ana Anderson from Harvard Medical School!
Her research focuses on understanding the pathways and mechanisms that regulate the #AntiTumor immune response.
#Marine #bacteria show potent #antitumor effects against #colorectal #cancer ...
| #Photobacterium | #lysis | #tumor | #therapy | Via @sciencex.bsky.social
#Mesothelin-targeted CAR-NK cells secreting the IL-2Rβγ agonist neo-2/15 sustain IL-2 signaling, boost c-Myc/NRF1-driven metabolism, resist TME-induced exhaustion, and exhibit stronger #AntiTumor activity and persistence in #SolidTumors.
#STTT #OpenAccess: doi.org/10.1038/s413...
