📰New & Featured | #Cell: #GPX4 released during #ferroptosis binds to dendritic #ZP3, activating cAMP-PPKA signaling
🔸Inhibits #glycolysis
🔸Impairs DC maturation and activation
🔸Eventually results in T cell priming defect
🧐Blocking GPX4-ZP3 interaction potentially drives #antitumor activity

🔥#Ferroptotic cancer cells release #GPX4 as an immunosuppressive damage-associated molecular pattern. GPX4 binds #ZP3 on dendritic cells, blocks DC–T cell priming, and dampens antitumor immunity. Targeting the GPX4–ZP3 axis boosts responses to chemo-, radio-, and immunotherapy.