Dual SHP2/MEK inhibition in #PDAC triggers mitochondrial remodeling and #LipidPeroxidase dependency, creating a #ferroptosis vulnerability; combining #GPX4 blockade or withaferin A enhances #tumor suppression across PDAC subtypes.

#STTT: doi.org/10.1038/s413...

#CLL cells accumulate lipid peroxides & iron, predisposing them to #ferroptosis; #BTK inhibition raises #TFRC and sensitizes cells, while combining #ibrutinib with #GPX4 blockade enhances efficacy, with TFRC and #ACSL1 emerging as targets.

#OpenAccess #STTT: doi.org/10.1038/s413...

📰New & Featured | #Cell: #GPX4 released during #ferroptosis binds to dendritic #ZP3, activating cAMP-PPKA signaling
🔸Inhibits #glycolysis
🔸Impairs DC maturation and activation
🔸Eventually results in T cell priming defect
🧐Blocking GPX4-ZP3 interaction potentially drives #antitumor activity

🔥#Ferroptotic cancer cells release #GPX4 as an immunosuppressive damage-associated molecular pattern. GPX4 binds #ZP3 on dendritic cells, blocks DC–T cell priming, and dampens antitumor immunity. Targeting the GPX4–ZP3 axis boosts responses to chemo-, radio-, and immunotherapy.

A fin-loop–like structure in #GPX4 anchors the enzyme to cell membranes, protecting neurons from #ferroptosis.A Cell study showed that a single point mutation (p.R152H) disrupts this protection, leaving neurons vulnerable to lipid peroxidation—especially in children with early-onset #dementia.

Researchers reveal #ferroptosis as a targetable vulnerability in #ChronicLymphocyticLeukemia, showing that BTK inhibition increases iron uptake via TFRC, and combining #ibrutinib with #GPX4 or ACSL1 targeting enhances ferroptosis.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This review outlines how #ferroptosis—driven by #GPX4 regulation, #IronMetabolism, and #LipidPeroxidation—offers a strategy to reverse #DrugResistance in digestive system #cancers, highlighting emerging ferroptosis-inducing therapeutic approaches.

#OpenAccess: doi.org/10.1016/j.ge...

🔥Hot Off the Press | A study in #Cell reports a missense mutation in #GPX4 (p.#R152H) leads to early-onset #neurodegeneration
🧐#GPX4R152H allele induces #ferroptosis (a key driver of neurodegeneration)
🧐GPX4-deficiency ↔️ #Dementia-like and #inflammatory molecular signatures

Defective enzyme causes nerve cells to die Researchers have discovered a protective mechanism in nerve cells that offers new targets for future therapies—especially for dementia.

Researchers show how a defect in the #enzyme #GPX4 can trigger #ferroptosis and lead to neuronal loss in certain forms of #dementia. The work provides new insights into cell protection mechanisms: go.tum.de/142494

@lmu-klinikum.bsky.social @helmholtzmunich.bsky.social

📷T.Orschmann & S. Lorenz

#Article in #MedComm
circRNA-SORE/UBQLN1/GPX4 Mediates the Acquisition of Sorafenib Resistance in Hepatocellular Carcinoma Through Inhibition of Ferroptosis doi.org/10.1002/mco2...

#circRNA #ferroptosis #sorafenib #resistance #UBQLN1 #GPX4

A recent review classifies eukaryotic #Selenoproteins, highlights the #Ferroptosis-linked role of #GPX4, and outlines therapeutic strategies for #Cancer by targeting selenoproteins. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Microwave dynamic therapy induces ferroptosis in colorectal cancer by targeting PTK2B to regulate STAT3-mediated GPX4 expression - Molecular Biomedicine Colorectal cancer (CRC) is a common malignant tumor of the digestive tract, and chemotherapy resistance along with adverse reactions during treatment present significant challenges in clinical practic...

#Research
Microwave dynamic therapy induces ferroptosis in colorectal cancer by targeting PTK2B to regulate STAT3-mediated GPX4 expression doi.org/10.1186/s435...

#ColorectalCancer #MWDT #Ferroptosis #PTK2B #GPX4 #STAT3

Recent review on #Ferroptosis offers new strategies to reverse #DrugResistance in DigestiveCancers through #GPX4 pathways, #IronMetabolism, and #LipidPeroxidation, paving the way for targeted and combination therapies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer LIMD1 (LIM domains containing 1) is a bona-fide tumour suppressor gene frequently lost during the early stages of non-small cell lung cancer (NSCLC) development, resulting in a worse outcome for LIMD1...

Congrats to Tyson Sharp and his colleagues on the bioRxiv paper on LIMD1 loss conferring #GPX4 sensitivity in lung cancer. An important #cancer #ferroptosis study.

www.biorxiv.org/content/10.1...