Understanding this pathway could unlock new strategies to protect muscle health & extend healthspan.

Global Longevity Federation 2026
🗓 March 23–24, 2026 | Rome, Italy

🔗https://longevityfederation.com/

#Longevity #AgingResearch #MuscleAging #Healthspan #AgingBiology #IronMetabolism

A detailed review of how iron, copper, zinc and other ions influence neuronal survival and pathology.
#IronMetabolism #MetalHomeostasis #Neurodegeneration #OxidativeStress
www.nature.com/articles/s41...

Iron and the immune system - Nature Reviews Immunology Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...

#WIMMReads: A new #review in Nature Reviews Immunology by Hal Drakesmith and Joe N Frost explores how #iron shapes immune responses in infection inflammation and cancer.
Read more 👇

#Immunology #Immunology #IronMetabolism #Infection
@rdm.ox.ac.uk @drakesmith-lab.bsky.social @medsci.ox.ac.uk

This review outlines how #ferroptosis—driven by #GPX4 regulation, #IronMetabolism, and #LipidPeroxidation—offers a strategy to reverse #DrugResistance in digestive system #cancers, highlighting emerging ferroptosis-inducing therapeutic approaches.

#OpenAccess: doi.org/10.1016/j.ge...

Watch the Tackling Iron Deficiency video on YouTube: youtu.be/frJ9iCjOYiM?...

#WIMMCommunity #Immunology #IronMetabolism #BCells #AntibodyResponse

GIMM – Gulbenkian Institute for Molecular MedicineGIMM – Gulbenkian Institute for Molecular Medicine Thank you very much for your generous donation and for sharing your testimony.We hope to more people feel inspired to join this mission of discovery and innovation!

Read the full story in @embojournal!
🔗 www.gimm.pt
#CellBiology #Immunology #Metabolism #Mitochondria #IronMetabolism #Homeostasis #OpenScience
(9/9)

This study shows that Jianpi Shengxue tablets are effective for #RenalAnemia in #CKD patients, significantly improving #IronMetabolism, relieving #Anemia symptoms, & enhancing nutritional status, promising advances in integrative #KidneyCare. #medsky

See: link.springer.com/article/10.1...

HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...

(1) New preprint from our lab!
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint

Recent review on #Ferroptosis offers new strategies to reverse #DrugResistance in DigestiveCancers through #GPX4 pathways, #IronMetabolism, and #LipidPeroxidation, paving the way for targeted and combination therapies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Transferrin is a drug candidate for the treatment of dry age-related macular degeneration (AMD) - PubMed Dysregulation of iron homeostasis plays a crucial role in retinal diseases, contributing to oxidative stress, inflammation, and ferroptosis, key processes that drive the degeneration of the retinal…

Transferrin supplementation restores iron balance, prevents ferroptosis, and protects retinal cells, implying a novel therapeutic path for dry AMD.
#AMD #Retina #Ophthalmology #Ferroptosis #Transferrin #IronMetabolism #Neuroprotection #CellDeathDisease buff.ly/xt4Anvk

SGLT2 inhibitor therapy and lower incidence of iron deficiency anaemia in patients with type 2 diabetes: A retrospective cohort study from Germany Aims Iron deficiency anaemia (IDA) is a common comorbidity in patients with type 2 diabetes mellitus (T2DM). Sodium–glucose cotransporter-2 inhibitors (SGLT2i) have been shown to modulate erythropoi...

Patients with chronic inflammatory conditions often experience anemia of inflammation where iron is sequestered in storage sites like #macrophages, despite sufficient total body stores. SGLT2 inhibitors counter this process, leading to a beneficial shift in #ironmetabolism

Iron and the Gut Microbiome: A Delicate Balance with Clinical Implications
Iron is a key regulator of host–microbiome ecology and immune-metabolic balance.
Exciting work in Nature Microbiology.
Full article link in comments 👇
#Microbiome #IronMetabolism #Immunology

This review provides a detailed overview of #Ferroptosis characteristics and the mechanisms that allow #CancerStemCells to evade it, emphasizing its potential as an innovative cancer treatment strategy. #LipidPeroxidation #IronMetabolism #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

🧬 Recent research explores how gut microbiota influences hepcidin, the master iron regulator, shedding light on liver fibrosis development. 👉 buff.ly/spToNlU

#PathogDis #Microbiome #IronMetabolism #LiverHealth

It is not possible to understand #Alzheimer’s disease without understanding the involvement of #OralMicrobiome pathogens.

Not only is Alzheimer’s a disease, it is a microbial ecosystem.

#PGingivalis
#OralBacterialTranslocation
#OuterMembraneVesicles
#Lactoferrin
#Neuroinflammation
#IronMetabolism

Ouderen >85j krijgen minder vaak kanker dan 75-85-jarigen. Uit onderzoek blijkt dat veranderingen in hoe cellen omgaan met ijzer daar wellicht deels voor verantwoordelijk zijn: oude cellen ontzeggen zichzelf ijzer, waardoor ze trager groeien en moeilijker kanker kunnen worden - #ironmetabolism

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.

Iron metabolism insufficiency in stem cells was not on my bingo card for mechanisms of aging that are chemoprotective... #Aging #LungCancer #IronMetabolism www.nature.com/articles/s41...