Ferroptosis by nanomaterials targeting cancer stem cells
www.scienceopen.com/hosted-docum...
#Ferroptosis #Nanomaterials #CancerStemCells #TargetedTherapy #CancerResearch

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model This study shows that stem-like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and ...

Proud to share my last first-author paper.

We report a new clinically relevant model of #breastcancer #brainmetastases and #cancerstemcells as key metastases drivers due to their adaptive interaction with brain cells and vasculature.

Thanks to Giuliana Pelicci’s lab (IEO, Milan) and co-authors.

Schematic overview of noncoding RNA functions in cancer cell plasticity. The figure is organized by RNA type: miRNAs regulate pluripotency inhibition, translational repression, mRNA degradation, EMT transition, cancer stem cell initiation, and metastasis; lncRNAs modulate epigenetic regulation, transcription, signaling pathways, chromatin architecture, alternative splicing, and dedifferentiation; circRNAs function as miRNA sponges, regulate transcription, interact with RNA-binding proteins, and influence self-renewal and apoptosis; tRNAs and tRNA-derived fragments regulate translation, mRNA stability, mitochondrial homeostasis, metabolic reprogramming, and hormone-dependent signaling.

Illustration of therapeutic strategies targeting noncoding RNAs in cancer. Approaches include synthetic miRNA mimics and lentiviral delivery for oncogene suppression, antisense oligonucleotides and RNA sponges for tumor suppressor restoration, CRISPR-based activation or repression of lncRNAs, synthetic circRNA sponges and Cas13-mediated cleavage, siRNA-loaded nanoparticles, and inhibition of tRNA methyltransferases to block translation and tumor growth.

📘 CHP Archive Spotlight #07
Review (2024) | Her et al.
How do noncoding RNAs drive cancer plasticity?
miRNAs, lncRNAs, circRNAs & tRNA fragments regulate stemness, EMT, epigenetics & therapy resistance — with emerging roles as biomarkers & targets.
🔗 doi.org/10.47248/chp...
#ncRNA #CancerStemCells

Graphical abstract illustrating cancer stem cell (CSC) heterogeneity driven by genetic, epigenetic, and environmental factors, and a proposed miRNA-dependent AAV strategy selectively eradicating heterogeneous CSCs to prevent recurrence.

📘 CHP Archive Spotlight #06
Perspective (2024) | Kondo
Targeting cancer stem cell heterogeneity & plasticity with a miRNA-dependent AAV system designed to eradicate diverse CSC populations while minimizing side effects.
🔗 doi.org/10.47248/chp...
#CancerStemCells #Heterogeneity #AAV

Graphical abstract illustrating ARSI-induced lineage plasticity in prostate cancer. Androgen receptor signaling inhibition promotes transition from prostate adenocarcinoma (PRAD) to aggressive CRPC variants with increased mesenchymal, basal, stem-like, and neural cell states, highlighting reversibility and tumor heterogeneity.

📘 CHP Archive Spotlight #05
Perspective (2024) | Jamroze, Liu & Tang
AR signaling inhibitors induce lineage plasticity in prostate cancer, promoting stem-like, mesenchymal & neural states driving CRPC & NEPC progression.
🔗 doi.org/10.47248/chp...
#LineagePlasticity #CRPC #CancerStemCells

#JMJD6 drives #Radioresistance and metastasis in #NSCLC via epigenetic EHF modulation, establishing #JMJD6 inhibition as a novel therapeutic approach to mitigate post-RT #Metastasis and #CancerStemCells.

#OpenAccess: doi.org/10.1038/s413...

Cancer stem cells: landscape, challenges and emerging therapeutic innovations
An updated review mapping the CSC field, unresolved challenges, and emerging therapeutic directions.
www.nature.com/articles/s41...
#CancerStemCells #StemCellTherapy #CancerInnovation

Targeting colorectal cancer stem cells via the SMYD3/c-MYC axis
A targeted strategy to suppress colorectal cancer stem cells by inhibiting key epigenetic and oncogenic pathways.
doi.org/10.1038/s413...
#ColorectalCancer #CancerStemCells #Epigenetics #TargetedTherapy

Dysadherin/YAP axis fuels stem plasticity and immune escape in liver cancer
Mechanistic insights into stem plasticity and immune evasion driven by Dysadherin–YAP signaling in liver cancer.
doi.org/10.1038/s413...
#CancerStemCells #StemPlasticity #LiverCancer #YAPSignaling

Cancer stem cells: advances in knowledge and implications for cancer therapy
New insights into cancer stem cell biology, signaling pathways, and therapeutic targeting strategies shaping next-generation cancer treatments.
doi.org/10.1038/s413...
#CancerStemCells #StemCellBiology #CancerTherapy

HMGCR inhibition reduces stemness & metastasis in HCC via Hedgehog signaling.
#HMGCR #HedgehogPathway #CancerStemCells #LiverCancer #Oncology
www.sciencedirect.com/science/arti...

Reviewing the biology & roles of #CancerStemCells (CSCs), their molecular pathways, and the mechanisms contributing to #TherapeuticResistance, with insights into the approaches for CSCs targeting emphasizing the potential of #DrugRepurposing.

#OpenAccess: doi.org/10.1016/j.ge...

An overview of #CancerStemCells (CSCs), their origins, associated signaling pathways, & their role in #tumorigenesis, with insights into CSC-targeting therapeutic strategies, their limitations, & future directions. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Reviewing the role of #epigenetic alterations on #CancerStemness, with a discussion on the therapeutic strategies targeting epigenetic modifiers to eliminate #CancerStemCells. #medsky @foxchasesurgonc.bsky.social

Read this #STTT #OpenAccess: doi.org/10.1038/s413...

Novel nanovaccine halts tumor growth and reduces cancer recurrence – BioNews Central A novel immunotherapy employs a nanovaccine that targets both bulk tumor cells and cancer stem cells to reduce the risk of post‑surgical recurrence and metastasis. ...

A novel #immunotherapy employs a #nanovaccine that targets both bulk #TumorCells and #CancerStemCells to reduce the risk of post‑surgical #recurrence and #metastasis.
#CancerImmunotherapy #CancerVaccine

This review explores the roles of pseudogene-derived #lncRNAs in modulating #CancerStemCells across multiple #Cancers and their #Clinical potential as #Biomarkers, #Diagnostics and #therapeutic targets. @tumscvdri.bsky.social #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

🧵 4/6
Review highlights CSC targeting—key to preventing relapse & drug resistance.

🌐 #CancerStemCells #OncologyResearch #PrecisionMedicine @kennarubin.bsky.social @science-george.bsky.social @myribw.bsky.social @michaeldonoian.bsky.social @ryuma21.bsky.social @martinbue.bsky.social

This review explores the interplay between #Ferroptosis and #CancerStemCells, which is essential for developing innovative strategies and improving cancer treatment outcomes by reducing recurrence rates. #medsky
#OpenAccess:
doi.org/10.1016/j.ge...

This new review sheds light on the complex relationship between #Ferroptosis and the biology of #CancerStemCells, aiming to develop new ways to eliminate these cells, ultimately improving #Cancer treatment and preventing recurrence. #medsky
#OpenAccess:
doi.org/10.1016/j.ge...

This review discuss recent findings on the dysregulated roles of pseudogene-derived lncRNAs in driving and developing #CancerStemCells in various #Cancers. ‪@tumscvdri.bsky.social‬ #medsky‬‬
#OpenAccess: www.sciencedirect.com/science/arti...

An overview of #CancerStemCells (CSCs), their origins, associated signaling pathways & their role in #tumorigenesis, with insights into CSC-targeting therapeutic strategies, their limitations & future directions. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

#ThrowbackThursday Special Topic article in JHC: "New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases."

Click to read for FREE: bit.ly/4bM1pm8

#angiogenesis #cancerstemcells #retina

This review provides a detailed overview of #Ferroptosis characteristics and the mechanisms that allow #CancerStemCells to evade it, emphasizing its potential as an innovative cancer treatment strategy. #LipidPeroxidation #IronMetabolism #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting

This review details how various cellular & soluble components in the #TumorMicroenvironment support the maintenance & function of #CancerStemCells (CSCs), and discusses the therapeutic implications of targeting this synergistic interplay. #CancerImmunotherapy #medsky

#OpenAccess: buff.ly/YrZeEzS

Elaine Fuchs presenting

🌟 Thanks to Elaine Fuchs from @rockefelleruniv.bsky.social & @hhmi.org for delivering an insightful seminar on “Tissue Stem Cells: Coping With Stress and Cancer,” hosted by @elhamazizi.bsky.social. This one was packed with thought-provoking science. #CancerResearch #CancerStemCells

SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma

The SLC27A5/PABPC1 axis induces #AlternativePolyadenylation (APA) of the METTL14-3’UTR, resulting in shorter 3’UTR METTL14 isoforms that evade miRNA-mediated suppression, thereby inhibiting #CancerStemCells in #HepatocellularCarcinoma. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Join us for the next IICD Seminar on May 14 at 2 PM ET with Elaine Fuchs from Elaine Fuchs from
@rockefelleruniv.bsky.social and @hhmi.org

🔬 Tissue Stem Cells: Coping With Stress and Cancer
📍 Schermerhorn 603
💻 Register: bit.ly/4jeH9gX

#CancerResearch #CancerStemCells #ColumbiaUniversity

Quantitative proteomics and phosphoproteomics analysis of patient-derived ovarian cancer stem cells High-grade serous ovarian carcinoma (HGSOC) is the deadliest gynecologic cancer. Key to the progression and ultimate lethality of this subtype is the intra-tumoral heterogeneity (ITH), which is define...

Our new study is out! 🚨
We used mass spectrometry to uncover a conserved stemness signature in ovarian cancer stem cells (OCSCs).
Check what we found and why it matters. 👇
#OvarianCancer #CancerStemCells #MassSpec #proteomics
www.mcponline.org/article/S153...

Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality

This review details the role of #ubiquitination molecules, E3 Ub ligases, #deubiquitinases, & transcription factors in regulating #CancerStemCells (CSC) and describe how the Ub-proteasome system modulates the signaling pathways governing CSC maintenance. #medsky

#OpenAccess:

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

Must-read review article!

Exploration of old, safe, approved and already-in-use drug candidates for treating non-cancerous diseases with anti-cancer activity, with a focus on #CancerStemCells and their clinical application for cancer treatment. #DrugRepurposing #medsky

www.sciencedirect.co...