#JMJD6 drives #Radioresistance and metastasis in #NSCLC via epigenetic EHF modulation, establishing #JMJD6 inhibition as a novel therapeutic approach to mitigate post-RT #Metastasis and #CancerStemCells.

#OpenAccess: doi.org/10.1038/s413...

Jmjd6/ETS axis as a target to overcome radioresistance in NSCLC
Integrative analysis reveals a Jmjd6–ETS signaling axis driving radioresistance in non-small cell lung cancer.
doi.org/10.1038/s413...
#Radioresistance #NSCLC #Epigenetics #Radiotherapy

KAT2A-driven SRSF11 succinylation enforces #Spliceosome-mediated RAD52 alternative splicing, enhancing HR-mediated #DNArepair and #Radioresistance in HCC, while genetic disruption of the KAT2A-SRSF11 axis radiosensitizes HCC cells.

#STTT #OpenAccess: doi.org/10.1038/s413...

FOSL1-PRMT1 transcriptional-epigenetic circuit promotes glioblastoma radioresistance via calcyphosine-mediated DNA repair and invasion - Molecular Biomedicine Radioresistance constitutes a major therapeutic barrier in glioblastoma (GBM), frequently leading to tumor recurrence and poor clinical outcomes. Despite advances in multimodal therapies, the molecula...

#Research
#FOSL1-#PRMT1 transcriptional-epigenetic circuit promotes #glioblastoma radioresistance via calcyphosine-mediated DNA repair and invasion doi.org/10.1186/s435...

#CAPS #DNA #Damage #Repair #Radioresistance

A novel PTM 'switch' involving the decrotonylation of Ku80 K568 by HDAC8 enabling its subsequent #SUMOylation by CBX4, drives DNA-PK complex assembly & #DoubleStrandBreak repair to promote #Radioresistance in malignancies.

#OpenAccess: doi.org/10.1038/s413...

Ultra-high dose rate #radiotherapy overcomes #radioresistance in #HeadAndNeckCancer by inducing #DNAdamage and activating a CD8+ T cell–M1 #macrophage feedback loop, enhancing the #TumorImmuneMicroenvironment for improved therapeutic outcomes.

#STTT: doi.org/10.1038/s413...

#ENPP1 maintains #GenomeIntegrity and drives #radioresistance in #TNBC, while its inhibition disrupts #DNARepair, activates STING signaling, enhances radiosensitivity, and induces durable #antitumor immunity. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

KAT2A-mediated #succinylation of the #splicingfactor SRSF11 at K419 enhances #DNARepair and #radioresistance in #HCC by promoting RAD52 exon inclusion, linking #AlternativeSplicing to #GenomicStability and offering a potential therapeutic target.

#STTT: doi.org/10.1038/s413...

🏆 Travel Grant Award Report – Wolfsberg 2025
⚡ Why do some cancers resist #radiotherapy?
At the #WolfsbergMeeting 2025, experts explored #Radioresistance — from metabolism & DNA repair to senescence.
👉 bit.ly/4q7KyC3
#Radiobiology #CancerResearch

🏆 Travel Grant Award – #WolfsbergMeeting 2025
How can targeting #hypoxia improve #headandneckcancer treatment?
An award-winning poster shows how novel compounds can overcome hypoxia-driven #radioresistance.
👉 shorturl.at/nY0WL
#RadiationBiology #Radiotherapy #HNSCC

Mechanistic insights into how the dynamic conversion of Ku80 K568 PTM from crotonylation to #SUMOylation regulates DNA-PK complex & #NHEJ initiation to promote DNA double-strand break repair and tumor #Radioresistance. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

How Do RAD54L and PSMC3IP Drive Stemness and Radioresistance? - ESTRO - OncoDaily How Do RAD54L and PSMC3IP Drive Stemness and Radioresistance? - ESTRO / cancer, ESTRO, ESTRO25, HNSCC, OncoDaily, Oncology, PSMC3IP, RAD54L, Radioresistance

ESTRO - How Do RAD54L and PSMC3IP Drive Stemness and Radioresistance?

@estroradiotherapy.bsky.social

oncodaily.com/voices/rad54...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ESTRO #RAD54L #PSMC3IP #Radioresistance #Stemness

🏆 Best Radiobiology Paper | #ESTRO25
RAD54L & PSMC3IP: key drivers of #DNArepair, stemness & #radioresistance in #HNSCC.
Findings suggest new synthetic lethality with PARP inhibitors.
👉 bit.ly/4lu1Cij

Je demande l'asile politique en Tunisie il y a plus de républicains qu'en France #radioresistance