#ENPP1 maintains #GenomeIntegrity and drives #radioresistance in #TNBC, while its inhibition disrupts #DNARepair, activates STING signaling, enhances radiosensitivity, and induces durable #antitumor immunity. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
Presenting REC-102: Preclinical in vivo updates for a potential ENPP1 inhibitor for the treatment of hypophosphatasia (HPP). Results of the study have been published in the Journal of Bone and Mineral Research.
👉 Read the paper: academic.oup.com/jbmr/advance... #HPP #ENPP1 #TechBio
#Recursion (Nasdaq #RXRX) Acquires Full Rights to #REV102, a Potential First-in-Class Oral #ENPP1 Inhibitor for #Hypophosphatasia
ir.recursion.com/news-release...
#ENPP1 #geriatrics
Dexamethasone (corticosteroid)
causes
calcium deposition
and degeneration
in anterior cruciate ligament cells
through endoplasmic reticulum stress
www.sciencedirect.com/science/arti...
Preventing calcification
of arteries and ligaments
requires sunlight
and low evening cortisol
