The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ The thymus is emerging as a model for studying organ regeneration and stem cell biology. While research has long focused on how antigen-presenting cells shape the T cell repertoire, recent discoverie....

👀 Our latest review is out in Immunological Reviews.

We revisit the search for #stemness in an involuting organ - and the paradox at the heart of #thymus biology 💡

#Thymus #StemCells #Regeneration #Immunology #TranslationalScience #OrganReconstruction @crick.ac.uk @ucl.ac.uk

shorturl.at/u6xJK

Inhibition of FOS‐Like Antigen 1 Reduces Chemoresistance to Temozolomide Through Stemness Reprogramming via IL‐6/STAT3Tyr705 Pathway The role of FOSL1 in TMZ response to GBM. FOSL1 enhances TMZ resistance by promoting cell cycle progression, MGMT expression, and IL-6-pSTAT3Tyr705-stemness axis. VEM is a potential candidate drug fo...

#Article in #MedComm
Inhibition of FOS-Like Antigen 1 Reduces #Chemoresistance to #Temozolomide Through #Stemness Reprogramming via IL-6/STAT3Tyr705 #Pathway

doi.org/10.1002/mco2...

#FOSL1 #TMZ #Glioblastoma #IL_6 #STAT3

Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers Gastrointestinal cancer stem cells obtain the ability of unlimited self-renewal, drug resistance, tumorigenicity as well as tendency of metastasis.

#Review in #MedComm
Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers doi.org/10.1002/mco2...

#CSC #GastrointestinalCancer #HepaticCancer #stemness #TherapeuticStrategy

A group of scientists from Sun Yat-sen University show that as #BladderCancer progresses, matrix stiffness and tumor #stemness increase.

High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.

💡 https://go.nature.com/4pEqerl

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

👉 buff.ly/AOrrON6

#p21 #ColonCancer #Stemness #NFκB

This latest review elaborates on how #Lactylation contributes to resistance in #Oncology by sustaining #Stemness, enhancing DNA repair, reprogramming metabolism, inhibiting #Ferroptosis, and promoting #Immunosuppression. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study shows that the restriction of YWHAB-mediated YAP #Cytoplasmic retention plays a key role in sustaining #Stemness, suggesting YAP suppression as a potential #therapeutic strategy for #OvarianCancer #PeritonealMetastasis. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Chloride channel accessory 4 suppresses stem cell-like properties of colorectal cancer and enhances anti-PD-1 immunotherapy

This study examines how CLCA4 regulates remission and #stemness transformation in #ColorectalCancer, emphasizing that modulating stemness through CLCA4 can remodel the #TumorMicroenvironment and enhance #ClinicalOutcomes. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

#Melanophore #Cells #TumorResilience #Persistent #Megazord
#GBM #Stemness
Regain GPCRs, growth factors that ECM constituents are storage of cells, debris and functions. A "cephalopoda act", reassemblying cells from pieces. Like a severed cell fragment resulted by CNS injury by surgery or diseases.

DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species - Nature Communications Cancer stem-like cells contribute to tumor growth and therapy resistance in glioblastoma. Here, authors identify that DHRS13 inhibition promotes differentiation of glioma stem-like cells by activating...

This week #JournalClub @labsoap.bsky.social #mitophagy #differentiation #stemness #cancer @nature.com www.nature.com/articles/s41...

SMYD3 interacts with & methylates c-MYC, influencing #ColorectalCancer carcinogenesis and #stemness genes expression. Therefore, targeting SMYD3 may inhibit proliferation & c-MYC-dependent #metastatic dissemination. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

How Do RAD54L and PSMC3IP Drive Stemness and Radioresistance? - ESTRO - OncoDaily How Do RAD54L and PSMC3IP Drive Stemness and Radioresistance? - ESTRO / cancer, ESTRO, ESTRO25, HNSCC, OncoDaily, Oncology, PSMC3IP, RAD54L, Radioresistance

ESTRO - How Do RAD54L and PSMC3IP Drive Stemness and Radioresistance?

@estroradiotherapy.bsky.social

oncodaily.com/voices/rad54...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ESTRO #RAD54L #PSMC3IP #Radioresistance #Stemness

I bet these cardiomyocytes were gorgeously synchronized and contractile before fixation... A metaphasic plate, microtubules not highlighted, however, if changes in myofibrils seen here are primary cells in tissue culture. KACHOW!
Nice share @mag2art.bsky.social :)
#celljunctions #stemness #cardiac