Epigenetics Update - Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation go.nature.com/4m76wDC

#Epigenetics #Lactylation #Chromatin #Cancer
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High-resolution insights without cell sorting; epigenometech.com

Naïve-like H9 hESC colonies exhibit distinct spatial patterns of pan Kla, LDHA, proteins involved in lactate transport, and general pluripotency markers. (A) Schematic showing the process of z-stack selection [left; created in BioRender by Betts Laboratory (2026); https://BioRender.com/k478v5i] and colony section assignment (right) for quantitative analysis of mean intensity. This figure was sublicensed under CC-BY 4.0 terms. (B) Representative immunofluorescence images of untreated naïve-like H9 hESC colonies stained for DAPI (nuclear marker), Pan Kla (global lactylation), LDHA, CX43, MCT1, SOX2, and OCT4. Scale bars: 50 μm.

Alexandra Kozlov, Robert Cumming & co from @westernu.ca examine the levels and spatial distribution of a newly identified protein modifier, lysine lactylation, and its relationship to cell fate in human embryonic stem cells. doi.org/10.1242/bio....

#PluripotentStemCells #Pluripotency #Lactylation

Lactylation of the SARS-CoV-2 spike protein is required for viral infection - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Lactylation of the SARS-CoV-2 spike protein is required for viral infection

This letter identifies #lactylation as a novel #PostTranslationalModification on the #SARSCoV2 S protein that enhances ACE2 and TMPRSS2 binding, promotes membrane fusion and #ViralEntry, while inhibition reduces infectivity.

#OpenAccess in #STTT:

Peritumoral colonic epithelial cell-derived GDF15 sustains colorectal cancer via regulation of glycolysis and histone lactylation - Nature Aging Nature Aging - Peritumoral colonic epithelial cell-derived GDF15 sustains colorectal cancer via regulation of glycolysis and histone lactylation

Epigenetics Update - Peritumoral colonic epithelial cell-derived GDF15 sustains colorectal cancer via regulation of
glycolysis and histone lactylation go.nature.com/4oDUGkj

#Epigenetics #Lactylation #Cancer #GDF15
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Empower your research with high-res epigenetic insights at epigenometech.com

This latest review elaborates on how #Lactylation contributes to resistance in #Oncology by sustaining #Stemness, enhancing DNA repair, reprogramming metabolism, inhibiting #Ferroptosis, and promoting #Immunosuppression. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Epigenetics Update - Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk go.nature.com/43GzkLr

#Epigenetics #AML #Cancer #Lactylation
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Empower your research with high-res epigenetic insights at epigenometech.com

Researchers show that lactate-induced #lactylation of the #helicase BLM at Lys24 enhances #HomologousRecombination repair and drives #anthracycline resistance, while #irinotecan counteracts this by suppressing BLM lactylation. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

#Lactylation (K424, K776, and K1028) of the #SARSCoV2 spike (S) protein enhances its interaction with the host receptor ACE2 or the host protease TMPRSS2, thereby promoting viral entry and infection. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

🧬 New Blog Post: Metabolic Machinations: Targeting TIP60-mediated NSB1 Lactylation May Improve Cancer Patient Survival

Read it here👉 bit.ly/47kYLEq

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#Epigenetics #CancerResearch #Genomics #DNARepair #Chromatin #Lactylation #ActiveMotif #Biotech #LifeSciences

PTM BIO supported this discovery with lactylation and histone antibodies, including:
PTM-1401RM L-Lactyllysine, PTM-1419RM H3K9la, PTM-1001RM Histone H3, PTM-1424RM H2BK16la, PTM-1414RM H3K14la, PTM-1406RM H3K18la, and others.
#RheumatoidArthritis #Lactylation #Epigenetics #Autoantibody #PTMBIO

Lactylation in Gynecological Malignancies: A Bridge between Lactate Metabolism and Epigenetic Therapy Lactate exerts regulatory effects on both cellular homeostasis and disease progression, far beyond being a mere metabolic waste product. As lactate accumulates, the level of lactylation increases sign...

🆕 Review Article: Lactylation in Gynecological Malignancies: A Bridge between Lactate Metabolism and Epigenetic Therapy

✍️ Authors: Ying Zhou et al

🔗 Read more: xiahepublishing.com/2996-3427/On...

👥
@IvanaKholova

@fredhutch

#Lactylation

This study demonstrates the role of glycolytic reprogramming in regulating HR repair through promoting protein #Lactylation and highlights the potential of irinotecan for reversing #anthracycline chemoresistance. #medsky

#STTT #OpenAccess: www.nature.com/articles/s41...

A new review published in Cancer Biology & Medicine reveals how lactate and its derivative lactylation process drive breast cancer progression, opening new therapeutic possibilities.
#Lactate #Lactylation #Breast cancer
Details: doi.org/10.20892/j.i...

TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis

TREM2 promotes #angiogenesis during #WoundHealing by enhancing #glycolysis and #lactylation in #macrophages in wounded tissues via activating the Akt/mTOR/HIF-1α signaling pathway. #medsky

#MostDownloaded: link.springer.com/article/10.1...

Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation Multi-omics sequencing and correlation analysis identified the beneficial role of Faecalibacterium prausnitzii (F. prausnitzii)-derived butyric acid (BA) as a key metabolite in the restoration of val....

Gut #microbiota‐derived #butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH #lactylation and #butyrylation
onlinelibrary.wiley.com/doi/10.1002/...
#CAVD #CVD #microbiome

Marathon runners

✨New issue! ✨

Check out the latest in #metabolism research.

Read about #Metabolism in the #Brain, #Liver, #Gut, #AdiposeTissue, Protein #Lactylation, #IntermittentFasting - and other topics!

https://bit.ly/4cMZTlz

Semaphorin 6A phase separation sustains a histone lactylation–dependent lactate buildup in pathological angiogenesis | PNAS Ischemic retinal diseases are major causes of blindness worldwide and are characterized by pathological angiogenesis. Epigenetic alterations in res...

Epigenetics Update - Semaphorin 6A phase separation sustains a histone lactylation–dependent lactate buildup in pathological angiogenesis bit.ly/4jlNszz

Chunqiao Liu/Yanhong Wei (Sun Yat-sen Uni.) in PNAS

#Epigenetics #Lactylation
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Gain deeper insight with epigenometech.com

Chromosomes in rainbow colors inside blue nuclei on a black background

👋Our April issue's out!
Cover: Live #chromosome tracking

👉🏼Perspective on #lactylation
👉🏼Review on #MechanicalForces in development
🔬 #MyocardialInfarction #PreclinicalStudy #NeuralStemCells #proteostasis #neurodegeneration #mitochondria #CellDeath #cancer & more!
www.nature.com/ncb/volumes/...

Emerging roles of lysine lactyltransferases and lactylation - Nature Cell Biology This Perspective discusses the emerging cellular roles of lysine lactylation, with a focus on the lactyl-CoA-independent pathway, and highlights the potential strategies of targeting lactylation for t...

Epigenetic Perspectives - Emerging roles of lysine lactyltransferases and lactylation go.nature.com/4cfV4kd

Bing Yang, Long Zhang, and Fangfang Zhou

#Epigenetics #Lactylation
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High-resolution insights without cell sorting; find out more at epigenometech.com

Epigenetic regulation of cardiac tissue development by lysine lactylation
doi.org/10.1016/j.hl...
#cardiac tissue development #lactylation #multi-omics

· Proteomics services for accurate identification and quantification of lactylation modifications.
#Ferroptosis #Lactylation #CustomAntibody #Proteomics #ColorectalCancer #LiverTransplantation #HDAC #PTM

Epigenetics Update – “DPF2 reads histone lactylation to drive transcription and tumorigenesis” www.pnas.org/doi/10.1073/...

From Kai Zhang from Tianjin Medical University
#Epigenetics #Lactylation

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Perfect for cancer, immunology, and aging; see more at epigenome.us