Common chemo drug increases risk of heart damage, study finds A CNIC research team has identified for the first time the biological mechanism underlying this susceptibility: high blood pressure creates a hidden metabolic vulnerability in the heart that becomes d...

One of the most widely used #chemotherapy drugs used in #cancer treatments can cause #heart damage, new research shows. This insight could be used to adapt treatment regimens - especially in patients with high #bloodpressure. #anthracycline

Researchers show that lactate-induced #lactylation of the #helicase BLM at Lys24 enhances #HomologousRecombination repair and drives #anthracycline resistance, while #irinotecan counteracts this by suppressing BLM lactylation. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

This study demonstrates the role of glycolytic reprogramming in regulating HR repair through promoting protein #Lactylation and highlights the potential of irinotecan for reversing #anthracycline chemoresistance. #medsky

#STTT #OpenAccess: www.nature.com/articles/s41...

Dose-dense anthracycline- and taxane-based chemotherapy remains the preferred treatment for selected patients with high-risk early breast cancer In patients with high-risk early breast cancer, cytotoxic chemotherapy is a crucial component of treatment for all disease subtypes.1 Regimens containing an anthracycline and a taxane are the most eff...

#Medsky🧪 #oncosky #episky #pharmasky #publichealth Dose-dense #anthracycline & #taxane based #chemotherapy remains the preferred treatment for selected patients with high-risk early #breastcancer @thelancet.bsky.social

www.thelancet.com/journals/lan...

www.thelancet.com/journals/lan...