A mechanical view on #metastasis and the role of #tumour cell viscosity
www.linkedin.com/feed/update/...
#mechanicalforces #biophysics #DanielMueller #biomechanics #ValentinGensbittel

#morphogenesis
#embryonicdevelopment
#mechanicalforces

Nice thread - and OA paper - on how Nature's *bricolage solves a problem for fruit flies' embryos.

*François Jacob's term for making do with constraints and byproducts at hand, like Gould & Lewontin's Spandrels of San Marco.

Chromosomes in rainbow colors inside blue nuclei on a black background

👋Our April issue's out!
Cover: Live #chromosome tracking

👉🏼Perspective on #lactylation
👉🏼Review on #MechanicalForces in development
🔬 #MyocardialInfarction #PreclinicalStudy #NeuralStemCells #proteostasis #neurodegeneration #mitochondria #CellDeath #cancer & more!
www.nature.com/ncb/volumes/...

StemBond hydrogels optimise the mechanical microenvironment for embryonic stem cells Studies of mechanical signalling are typically performed by comparing cells cultured on soft and stiff hydrogel-based substrates. However, it is challenging to independently and robustly control both substrate stiffness and tethering of extracellular matrix (ECM) to substrates, making ECM tethering a potentially confounding variable in mechanical signalling investigations. Moreover, poor ECM tethering can lead to weak cell attachment. To address this, we developed StemBond hydrogels, a hydrogel formulation in which ECM tethering is stable and can be varied independently of stiffness. We show that soft StemBond hydrogels provide an optimal format for culturing embryonic stem (ES) cells. We find that soft StemBond substrates improve the homogeneity of ES cell populations, boost their self-renewal, and increase the efficiency of cellular reprogramming. Our findings underline how soft microenvironments impact mechanosensitive signalling pathways regulating self-renewal and differentiation, indicating that optimising the complete mechanical microenvironment will offer greater control over stem cell fate specification.

Very proud of @celinelabo [and co] for their recent work in developing optimal mechanical microenvironments to study embryonic stem cell fate #bioxriv #stemcells #mechanicalforces #biophysics

x.com/Jose_Silva_Lab… biorxiv.org/content/10.110…