Elevated Spy1 drives sustained expansion of neural stem cells, increases stemness characteristics, decreases differentiation, and increases susceptibility to oncogenic transformation. #neuralstemcells #braindevelopment https://ow.ly/c7AR50XSyaf
ISSCR | The Gairdner Foundation | SickKids Foundation
The review examines the subventricular zone as a reservoir of #NeuralStemCells, emphasizing its importance in #Neurodegeneration, #Glioblastoma, and #NeuralRepair, and its potential for #RegenerativeTherapies. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
@Qkine manufacture the only animal origin-free and bioactive DKK-1 for reproducible stem cell cultures.
View human DKK-1 and buy online > zurl.co/TOv1j
View the DKK-1 technote > zurl.co/X3Pix
#stemcells #animaloriginfree #neuralstemcells
"Sox5 controls the establishment of quiescence in neural stem cells during postnatal development"
📖 Check out the study: doi.org/10.1371/jour...
#NeuralStemCells #Neuroscience #StemCellBiology #DevelopmentalBiology #Neurodevelopment #Science #Academic
New neurons are generated throughout adult life in the adult neurogenic niche in the hippocampus through activation of reversibly quiescent neural stem cells (NSCs). The cover highlights DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Medina-Menéndez et al. report that Sox5 is required to control the correct establishment of quiescence during the first postnatal weeks of dentate gyrus development, which is essential for establishing long-lasting adult neurogenesis. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002654
Ever wondered how adult #NeuralStemCells develop and acquire their lifelong potential?
Excited to share our latest work on the origin of #AdultNeurogenesis by Cris Medina
@paulatiradom.bsky.social Lingling Li & @pilar-rguezm.bsky.social now in @plosbiology.org🧪🧠
@institutocajal.bsky.social
👇🧵
Top: CD133 showed specific enrichment on the apical surface of radial glial cells (RGCs) in the developing ventricular zone (VZ) from postnatal day 0 (P0) to P15. Ciliary membrane marker (ARL13B) and the ciliary microtubule marker acetylated-tubulin (ac-TUB) indicated ependymal cell (EPC)-lineage differentiation. Cell proliferating marker (Ki67) and neural stem cell (NSC)-lineage marker (ASCL1) indicated NSC-lineage transition. The framed region was further magnified to show details. The boundary between lateral ventricle (LV) and VZ was denoted by the yellow dotted line for better distinguishing ciliary ac-TUB and cytoplasmic ac-TUB in (B). The scale bars are 20 μm. Bottom: A model illustrating how TFEB functions in the process of bGPC specification during VZ development.
#NeuralStemCells (NSCs) & ependymal cells (ECs) are derived from #RadialGlialCells. This study uses #scRNAseq to characterize cell fate trajectories in the developing #VentricularZone, identifying TFEB as a regulator of the NSC/EPC balance @plosbiology.org 🧪 plos.io/3HbrsJG
Top: CD133 showed specific enrichment on the apical surface of radial glial cells (RGCs) in the developing ventricular zone (VZ) from postnatal day 0 (P0) to P15. Ciliary membrane marker (ARL13B) and the ciliary microtubule marker acetylated-tubulin (ac-TUB) indicated ependymal cell (EPC)-lineage differentiation. Cell proliferating marker (Ki67) and neural stem cell (NSC)-lineage marker (ASCL1) indicated NSC-lineage transition. The framed region was further magnified to show details. The boundary between lateral ventricle (LV) and VZ was denoted by the yellow dotted line for better distinguishing ciliary ac-TUB and cytoplasmic ac-TUB in (B). The scale bars are 20 μm. Bottom: A model illustrating how TFEB functions in the process of bGPC specification during VZ development.
#NeuralStemCells (NSCs) & ependymal cells (ECs) are derived from #RadialGlialCells. This study uses #scRNAseq to characterize cell fate trajectories in the developing #VentricularZone, identifying TFEB as a regulator of the NSC/EPC balance @plosbiology.org 🧪 plos.io/3HbrsJG
Top: CD133 showed specific enrichment on the apical surface of radial glial cells (RGCs) in the developing ventricular zone (VZ) from postnatal day 0 (P0) to P15. Ciliary membrane marker (ARL13B) and the ciliary microtubule marker acetylated-tubulin (ac-TUB) indicated ependymal cell (EPC)-lineage differentiation. Cell proliferating marker (Ki67) and neural stem cell (NSC)-lineage marker (ASCL1) indicated NSC-lineage transition. The framed region was further magnified to show details. The boundary between lateral ventricle (LV) and VZ was denoted by the yellow dotted line for better distinguishing ciliary ac-TUB and cytoplasmic ac-TUB in (B). The scale bars are 20 μm. Bottom: A model illustrating how TFEB functions in the process of bGPC specification during VZ development.
#NeuralStemCells (NSCs) & ependymal cells (ECs) are derived from #RadialGlialCells. This study uses #scRNAseq to characterize cell fate trajectories in the developing #VentricularZone, identifying TFEB as a regulator of the NSC/EPC balance @plosbiology.org 🧪 plos.io/3HbrsJG
Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).
Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. @aixa-v-morales.bsky.social &co show that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @plosbiology.org 🧪 plos.io/44Su34u
Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).
Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. @aixa-v-morales.bsky.social &co show that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @plosbiology.org 🧪 plos.io/44Su34u
Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).
Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. @aixa-v-morales.bsky.social &co show that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @plosbiology.org 🧪 plos.io/44Su34u
BIOCOMPATIBILITY OF LARGE-AREA 2-DIMENSIONAL ELECTRONIC MATERIALS WITH NEURAL STEM CELLS
Akinwande, D., Duan, X. et al.
Paper
Details
#Biocompatibility #2DElectronicMaterials #NeuralStemCells
Qkine human ciliary neurotrophic factor (CNTF) is animal origin-free, carrier-free and tag-free to ensure a homogenous cell population with exceptional lot-to-lot consistency.
View human CNTF and buy online > zurl.co/w0Wwv
#cytokines #glial #neuralstemcells
New review explores the shared origin of #ependymalcells & #neuralstemcells & the potential interplay among different subventricular zone cell populations. Insights into cell fate decisions will inform the therapeutic potential of ependymal cells ow.ly/v5UF50WlHLu @isscr.org
Published in Microsystems & Nanoengineering, a study combines magnetic Cellbots with a piezoelectric micromachined ultrasound transducer (pMUT) array to achieve targeted cell delivery and localized differentiation.
#Neuralstemcells #cellbots
Details: doi.org/10.1038/s41378-025-00900-y
Chromosomes in rainbow colors inside blue nuclei on a black background
👋Our April issue's out!
Cover: Live #chromosome tracking
👉🏼Perspective on #lactylation
👉🏼Review on #MechanicalForces in development
🔬 #MyocardialInfarction #PreclinicalStudy #NeuralStemCells #proteostasis #neurodegeneration #mitochondria #CellDeath #cancer & more!
www.nature.com/ncb/volumes/...
Top left: Representative IF co-labeling of Nestin and tdT (DsRed) in the E15.5 VZ/SVZ. Top right: Representative IF co-labeling of Ki67 and tdT (DsRed). The dashed line roughly marks the ventricular zone. Middle: Representative Sox2 IF staining in the VZ/SVZ of wild-type (left) and Gas1 KO (right) mice at P0.5. The dashed lines roughly mark the boundary of VZ/SVZ. Bottom: Schematic summarizing the developmental origin and function of the Gas1high NSC subpopulation.
Quiescent #NeuralStemCells (qNSCs) in the adult mouse SVZ have a limited capacity to generate #glia. This study shows that a subpopulation of multipotent qNSCs with high Gas1 expression can produce #oligodendrocytes throughout life & after demyelinating injury @plosbiology.org 🧪 plos.io/4iY4nbh
Top left: Representative IF co-labeling of Nestin and tdT (DsRed) in the E15.5 VZ/SVZ. Top right: Representative IF co-labeling of Ki67 and tdT (DsRed). The dashed line roughly marks the ventricular zone. Middle: Representative Sox2 IF staining in the VZ/SVZ of wild-type (left) and Gas1 KO (right) mice at P0.5. The dashed lines roughly mark the boundary of VZ/SVZ. Bottom: Schematic summarizing the developmental origin and function of the Gas1high NSC subpopulation.
Quiescent #NeuralStemCells (qNSCs) in the adult mouse SVZ have a limited capacity to generate #glia. This study shows that a subpopulation of multipotent qNSCs with high Gas1 expression can produce #oligodendrocytes throughout life & after demyelinating injury @plosbiology.org 🧪 plos.io/4iY4nbh
Top left: Representative IF co-labeling of Nestin and tdT (DsRed) in the E15.5 VZ/SVZ. Top right: Representative IF co-labeling of Ki67 and tdT (DsRed). The dashed line roughly marks the ventricular zone. Middle: Representative Sox2 IF staining in the VZ/SVZ of wild-type (left) and Gas1 KO (right) mice at P0.5. The dashed lines roughly mark the boundary of VZ/SVZ. Bottom: Schematic summarizing the developmental origin and function of the Gas1high NSC subpopulation.
Quiescent #NeuralStemCells (qNSCs) in the adult mouse SVZ have a limited capacity to generate #glia. This study shows that a subpopulation of multipotent qNSCs with high Gas1 expression can produce #oligodendrocytes throughout life & after demyelinating injury @plosbiology.org 🧪 plos.io/4iY4nbh
Glutamine-glutamate intercellular relay model for brain sparing
Our latest preprint…Adrien Franchet, Yuhong Jin et al @crick.ac.uk show that circulating glutamine drives brain sparing during nutrient restriction. Great collab with labs of Yaël Grosjean and Ian Gilmore.
#metabolism #Drosophila #neuralstemcells
www.biorxiv.org/content/10.1...
Dario & Tamas look forward to meeting you!
Got a project in mind? Ask about our Innovation Projects! 📄All info in the flyer 👇
#SingleCell #Neurobiology #NeuralStemCells #StemCells #Transcriptomics #ISSCRAthens #ISSCR
#microglia #astrocytes #oligodendrocytes #schwanncells and side collaborators #neuralstemcells 😀😀😀😀😀
