Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia Shi et al. delineate an interplay among tumor cells, immune cells, and the nervous system that drives cancer cachexia and anorexia. Specifically, tumor-derived CSF1 induces macrophage GDF15, which…

#Cachexia is a dangerous & difficult-to-treat #wasting of muscle and fat induced by #cancer. With help from Promethion Core #Metabolic Cages, scientists identified a novel #tumor-#immune-#neural circuit & disrupted it to relieve cachexia in mice.

buff.ly/MPmanAc

#GDF15

Peritumoral colonic epithelial cell-derived GDF15 sustains colorectal cancer via regulation of glycolysis and histone lactylation - Nature Aging Nature Aging - Peritumoral colonic epithelial cell-derived GDF15 sustains colorectal cancer via regulation of glycolysis and histone lactylation

Epigenetics Update - Peritumoral colonic epithelial cell-derived GDF15 sustains colorectal cancer via regulation of
glycolysis and histone lactylation go.nature.com/4oDUGkj

#Epigenetics #Lactylation #Cancer #GDF15
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Empower your research with high-res epigenetic insights at epigenometech.com

Growth/Differentiation Factor 15 Promotes a Pro‐Regenerative Response in Chondrocytes Upon Cartilage Injury After cartilage injury, oxidative stress results in a posttraumatic cell fate decision: Intracellular ROS accumulation initiates a p53-dependent stress response in chondrocytes, including the transcr...

#Article in #MedComm
Growth/Differentiation Factor 15 Promotes a Pro-Regenerative Response in Chondrocytes Upon Cartilage Injury doi.org/10.1002/mco2..., studied by Dr. @janariegger.bsky.social and her group.

#CellFateDecision #chondrocytes #PTOA #GDF15 #PosttraumaticOsteoarthritis

🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK

Metabolic Messenger: growth differentiation factor 15 - Nature Metabolism Breit and Tsai provide a concise overview of the role of GDF15 as a signalling molecule in the context of metabolic health and disease.

METABOLIC MESSENGERS | GDF15

Samuel N. Breit & Vicky W. Tsai

A concise overview of the role of #GDF15 as a signalling molecule in the context of metabolic health and disease.

🧪

Nuevo estudio #CIBERDEM ➕ #CIBERCV revela que #GDF15 podría ser un biomarcador para evaluar la insuficiencia cardíaca en pacientes con déficit de hierro

➡️ www.ciberisciii.es/noticias/dem...

@idibell.bsky.social @urv.cat

Ginger root to represent the food and drinks containing ginger that may help reduce morning sickness symptoms.

Feeling nauseous? Morning sickness is normal & affects 7 out of 10 women.
Hormone GDF-15 is the culprit.
Worse in the first trimester, it clears by 16-20 weeks
Manage it with:
Rest
Eat little & often
Avoid excess sugar & saturated fats
Have food & drinks containing ginger

#Pregnancy #Baby #GDF15

Promising results from a Phase 2 trial published in #NEJM showcase ponsegromab, a GDF-15 inhibitor, as a new alternative for cancer cachexia, a devastating syndrome affecting millions

@nejm.org

#Onco404 #Cancer #Kanser #Cachexia #MedSky #OncSky #Kaşeksi #GDF15 #Oncology #ClinicalTrials #PDAC #CRC

GDF15 links adipose tissue lipolysis with anxiety - Nature Metabolism Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

New from the Steinberg lab #GDF15 drives anxiety like behaviors in mice and is linked to adipose tissue lipolysis.

최신 연구로 밝혀진 임신 입덧의 원인과 완화 전략: GDF15 호르몬의 비밀 🤰 임신 중 가장 흔하면서도 힘든 증상 중 하나인 입덧, 누구나 들어봤지만 정확한 원인은 알쏭달쏭했죠. 최근 과학계에서는 이 고통스러운 임신 초기 증상의...

충격! 임신 입덧의 진짜 원인은 태아가 만드는 GDF15 호르몬이었다! 🤯

크래커, 생강차가 도움된다는데... 5-10년 내 신약 개발도 진행 중!

입덧으로 고생 중이라면 꼭 읽어보세요 👇
#임신입덧 #GDF15 #예비맘꿀팁

🔗자세히 보기: allbrand.co.kr/%ec%b5%9c%ec...

임신부를 위한 입덧의 원인과 관리, GDF15 호르몬 깊이 알기 🤰 임신부를 위한 입덧의 원인과 관리법에 대해 알아보세요! 특히 최근 주목받는 GDF15 호르몬의 역할부터 효과적인 입덧 완화 방법까지 상세히 알려드립니다....

😱 입덧의 원인이 밝혀졌다! GDF15 호르몬이 범인!

아침마다 화장실로 직행하는 임산부들, 이제 과학이 답을 찾았어요. 생강차와 소량 다량 식사가 도움된대요!

더 놀라운 사실과 관리법 확인하기 👇
#임신 #입덧 #GDF15 #임산부꿀팁

🔗자세히 보기: allbrand.co.kr/%ec%9e%84%ec...

Secreted GDF15 maintains transcriptional responses during DNA damage-mediated senescence in human beta cells - PubMed Type 1 diabetes (T1D) is a chronic metabolic disease resulting from an autoimmune destruction of pancreatic beta cells. Beta cells activate various stress responses during the development of T1D, incl...

8/ DREAM researcher Dr. Peter Thompson and his lab revealed that #GDF15 is crucial for regulating gene expression during beta cell senescence in #Type1Diabetes, but not for cell survival. Could it be a target for T1D therapies? #BetaCellResearch #CellSenescence pubmed.ncbi.nlm.nih.gov/39196800/

Commented on this before I saw your post. Search #GDF15 if you want to find it :)

Olink Reveal — Olink®

Browsing the list of proteins in Olink Reveal olink.com/products/oli... which is their new $99 NGS “biomarker”-focused offering. Don’t see #GDF15, which is THE biomarker in Olink data. Am I missing something?

Our pregnancy cohort analysis over Christmas turned up trumps!

Loads of pregnancy related proteins - and peptides identified on our 7600 ZenoTof and PEAKS search.

Favourite hit - corticosteroid releasing hormone. Circulates at ~ 100 pg/mL!

Oh - and #GDF15 showed up again!

3/ First, we focused on #FGF21 and #GDF15, two metabokines affecting energy balance.
We found that GDF15 transiently increased upon diet-induced weight loss whereas FGF21 decreased following weight-loss maintenance with combined exercise and GLP-1 analog.

#GDF15 "was found to be the most significant plasma protein associated with brain aging". More UK Biobank data.

Had a great day at the Belgian Proteomics Association 2024 meeting in Ghent yesterday. Presented our #GDF15 pregnancy story.

Thanks to Waters for the support!

Went for a run this morning - Ghent is beautiful - loving the Christmas decorations!

#proteomics #hyperemesisgravidarum

UK Biobank, so of course it's more #GDF15.