#LungCancer #TargetedTherapiesOncTalk #LungCancerInformation #cachexia

Dr. Suraj Samtani, now presenting: "Diagnosis and Treatment of Cancer Cachexia in Lung Cancer".

The Unignorable Numbers
Lung cancer remains the leading cause of cancer mortality in the United States, with cachexia compounding the challenge at every stage.

#LungCancer #TargetedTherapies #Cachexia

Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predicts Cachexia and Prognosis in Hepatocellular Carcinoma Patients

This research evaluated the predictive role of FLIS in #HCC patients with #Cachexia, suggesting that FLIS may facilitate early identification and #Prognostic assessment, and offering new perspectives for improving patient care. #medsky

To read: doi.org/10.1007/s115...

Creatinine in blood: normal values (level) and causes of increase/decrease #creatinine #cachexia
... Continue to: youtube.com/shorts/huIxc...

Neutrophil-derived Reactive Oxygen Species Mediate Doxorubicin-induced Cardiotoxicity and Skeletal Myopathy | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological S... Doxorubicin (DOX), an effective chemotherapy, exhibits a narrow therapeutic index and detrimental adverse effects involving muscle atrophy and dysfunction. The precise mechanisms underlying DOX-mediat...

Some #cardioimmunology of doxorubicin-induced #cachexia.

Shout out to the team for their amazing effort.
journals.physiology.org/doi/abs/10.1...

Creatinine in blood: normal values (level) and causes of increase/decrease #creatinine #cachexia
... Continue to: youtube.com/shorts/huIxc...

Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia Shi et al. delineate an interplay among tumor cells, immune cells, and the nervous system that drives cancer cachexia and anorexia. Specifically, tumor-derived CSF1 induces macrophage GDF15, which…

#Cachexia is a dangerous & difficult-to-treat #wasting of muscle and fat induced by #cancer. With help from Promethion Core #Metabolic Cages, scientists identified a novel #tumor-#immune-#neural circuit & disrupted it to relieve cachexia in mice.

buff.ly/MPmanAc

#GDF15

New Special Issue in the Journal of Cachexia, Sarcopenia and Muscle The Role of Fat Tissue and Lipids in Cachexia and Sarcopenia Read it now

Check out the latest Special Issue from the Journal of Cachexia, Sarcopenia and Muscle on The Role of Fat Tissue and Lipids in Cachexia and Sarcopenia.

Explore the collection: https://ow.ly/SROY50YhHQc

#Cachexia #Sarcopenia #MuscleResearch #Metabolism

Creatinine in blood: normal values (level) and causes of increase/decrease #creatinine #cachexia
... Continue to: youtube.com/shorts/huIxc...

Vulnerable patients were less likely to receive subsequent therapies (60% vs 72%), suggesting that supportive care, fitness optimization, and post‑CCRT access may be critical intervention points.
#Oncology #ThoracicOncology #CancerCare #LungCancer #NSCLC #Frailty #CCRT #Cachexia

✨New issue✨

Check out the latest in #Metabolism research from across all disciplines.

Read about #AMPK, #Cachexia, #ImmuneSignalling, #Microbiome, #NAD, #Nutrition, #TissueCrosstalk and many more topics! 🧪

www.nature.com/natmetab/vol...

Impact of vulnerability on concurrent chemoradiotherapy outcomes in patients with locally advanced non-small cell lung cancer using an integrated clinical trial database
@tamedoncol.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#cachexia #oncology #NSCLC #openaccess

This review links #cancer #cachexia to cross-organ #MetabolicRemodeling and #inflammatory signaling, showing how tumor-driven mediators disrupt #homeostasis and fuel wasting, while outlining emerging therapeutic strategies.

#OpenAccess in #STTT: doi.org/10.1038/s413...

⚡Our January issue is live! Including the first Nature Medicine Commission Report (introduced in our Editorial), new research on #infertility, #huntingtonsdisease, #cancer #cachexia, #HIV, #genetherapy, #microbiome therapy, News & Opinion and much more
https://www.nature.com/nm/volumes/32/issues/1

Weight Loss in Cancer: Coordinated Multi-Organ Response

Weight Loss in Cancer: New research led by #HelmholtzMunich shows that #cachexia affects multiple organs in a coordinated metabolic way, not just muscles.

👉 Read more: t1p.de/q0ukw

@ondrej-kuda.bsky.social
@iphys-cas.bsky.social
@diabresearch-dzd.bsky.social
@dzhk.de

-Cancer patients often face challenges with malnutrition and weight loss ( #cachexia), meaning a general dietary restriction may be harmful without careful medical supervision
Further research & #clinicaltrials are needed to develop safe & effective dietary guidelines for human cancer patients.

Drosophila midgut tumor-induced insulin resistance systemically remodels lymph gland hematopoiesis during cancer cachexia Cancer cachexia involves systemic metabolic deregulation along with classical features of muscle wasting, lipolysis, and chronic inflammation. While tumor non-autonomous effects on peripheral organs a...

My 1st PhD student, Ujjayita's 1st preprint! We show how the niche-progenitor micro-environment & hematopoiesis is remodelled during tumor induced cachexia conditions in Drosophila!
#cancer #cachexia #Drosophila #hematopoiesis #signaling
www.biorxiv.org/content/10.1...

The canonical #ERstress IRE1α/XBP1 pathway mediates skeletal muscle wasting during #PancreaticCancer #cachexia

By A. Joshi, A. Kumar & colleagues @uh.edu

🗞️ doi.org/10.1038/s443...

This study from @fudan-university.bsky.social identifies oral Z526 as a promising anti-CAC agent that targets #NFκB signaling and #OxidativeStress, offering new hope for cancer-associated #Cachexia therapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Cachexia progression differs among mouse models of metastatic triple-negative breast cancer | American Journal of Physiology-Cell Physiology | American Physiological Society Cancer-associated cachexia decreases the quality of life, reduces therapy response, and diminishes survival prospects. Effective cachexia countermeasures remain a significant unmet need. Research into...

Congrats to the CMR's Alastair Saunders, Paul Gregorevic and Team for their new AJPCellPhys paper "Cachexia progression differs among mouse models of metastatic triple-negative breast cancer"
#Cancer #cachexia
journals.physiology.org/doi/full/10....

Researchers found that the FLIS derived from gadoxetic acid-enhanced #MRI
helps detect #Cachexia and predict prognosis in #HCC, advancing noninvasive imaging biomarkers
for early intervention. #medsky
Read more: link.springer.com/article/10.1...

A new @nature.com Reviews Drug Discovery article highlights the first candidate drug to combat #cachexia — a major step toward treating cachexia, a devastating condition affecting many people with cancer.

🔗 Read the full article: www.nature.com/articles/d41...

#CancerResearch

📰New & Featured | #Nature: #RNA profiling reveals molecular clues behind cancer-associated cachexia 🧬
➡️ Distinct expression patterns in skeletal muscle
➡️ New targets for reversing cancer-related muscle loss
🔗Read more: www.nature.com/articles/d41...
#Cachexia #MuscleLoss #Cancer #SkeletalMuscle

#Cachexia is a common co-morbidity in a number of late stage cancers. It’s frequently seen in #PancreaticCancer. Most drug discovery companies are focused on treating the cancer itself, but late stage disease is often so biologically complex that this is a bit like banging your head against a wall.

Could a Drug in Clinical Trials Mean Breakthrough in Cancer Cachexia Treatment? | The Hormel Institute A new drug making its way through clinical trials shows promising options as a way to help patients manage cancer cachexia, which affects a person’s appetite and leads to the loss of fat and skeletal ...

#MedSky🧪 #Oncosky #pharmsky #immunosky #publichealth #Drugdiscovery Can Pfizer’s appetite-boosting antibody #ponsegromab address a cancer- #cachexia & help patients live longer in the process?
www.pfizer.com/news/article...

hi.umn.edu/news/could-d...

www.cancer.gov/news-events/...

A health-system-scale, episode-resolved multimodal atlas of cancer cachexia Cancer cachexia is a wasting syndrome with outsized impact on morbidity and mortality. Neither the etiology of cachexia, nor its consequences on patient physiology and outcomes, are well-understood. H...

The largest description of cancer #cachexia to date across all tumor types and over time using data from 60,000 people. @edreznik.bsky.social redefines what we know about human cachexia integrating genetics, lab values, and treatment lines. www.medrxiv.org/content/10.1...

Cancer #cachexia stands as a relentless, treatment-resistant syndrome that devastates muscle and metabolism. Our September publication review flexes new insights into the condition.

Read it now
aurorascientific.com/flexing-new-insights-in-...

#CCAD2025 #CachexiaWastingMatters

#Cachexia

Cancer #cachexia is an urgent but under-recognised challenge in lung cancer. At @LUNGevity’s #ILCSC25, @yvonnediaz.bsky.social will join Dr Richard Dunne to highlight hope underway from @cancergrand.bsky.social Team CANCAN.

Sign up 👇

reg.eventmobi.com/ilcsc2025/regi… #LCSM

Molecular subtypes of human skeletal muscle in cancer cachexia | Nature Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates potential target pathways for future research.

#Tumor patients can lose muscle mass (cachexia) -> bad prognosis. Study looks at all RNAs in skeletal muscles of cancer patients. Finds 2 complex clusters with distinct RNA expression, 1 cluster with stronger cachexia. Progress but no simple explanation for #cachexia.
www.nature.com/articles/s41...