Bullet With Butterfly Wings - Remastered 2012

I wish other people’s prescribing didn’t feel so personal…

#IDSky #AMSSky #PharmSky
#FridayFeelings

open.spotify.com/track/6GtX0j...

You have until August 31 to submit your work to Molecular Pharmacology's upcoming special collection, which celebrates the world-leading research showcased by attendees of the 5th Transatlantic ECI GPCR Symposium. Learn more: https://ow.ly/CGTm50YGvB9
#pharmsky 🧪

The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial | Nature Medicine Therapies targeting the natriuretic peptide system have the potential to reduce death or heart failure events in heart failure with reduced ejection fraction. Here we assess XXB750, a human monoclonal antibody activating natriuretic peptide receptor 1, in patients with heart failure. Patients with heart failure and a left ventricular ejection fraction <50% were enrolled. Those patients who were on background angiotensin-converting enzyme inhibitor or angiotensin receptor blocker treatment were randomized to receive 60 mg XXB750, 120 mg XXB750 or placebo in a blinded fashion or sacubitril/valsartan treatment in an open-label fashion. Those patients on background sacubitril/valsartan treatment were randomized to either 60 mg XXB750, 120 mg XXB750 or placebo treatment in a blinded fashion. The primary endpoint was the change in NT-proBNP levels at 16 weeks after treatment initiation, and safety was also assessed. We randomized 136 participants (70% male, 30% female) to 60 mg XXB750 (n 

"Phase 2 trial finds XXB750, an NPR1 agonist antibody, improves outcomes in heart failure patients with LVEF<50%. Promising step!" PMID:41912806, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04313-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1093/nar/gkag248 No description available

YAP, regulated by nuclear G-actin binding, is key in Hippo pathway, affecting processes like cell proliferation, cancer and more. PMID:41854080, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag248 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A group of people in lab coats sitting in a lecture hall, attentively listening. They appear engaged and interested, suggesting an academic or professional setting.

PharmD student Joey Jimenez completed a Residency Track APPE & an Antimicrobial Stewardship PharmD specialization, to be residency-ready. He's one of a record number of Badgers personalizing their #PharmD through the School's specialized tracks. https://bit.ly/3Pu4a5E #PharmEd #PharmSky #RxSky

Tackling polypharmacy in primary care: Reflecting on learning from the IMPPP clinical trial webinar Polypharmacy (taking five or more medications) is a major challenge facing primary care today, with implications for patient safety, treatment burden, and NHS resources. Yet there is limited high-quality evidence to guide how best to manage it in everyday practice. The Improving Medicines use in People with Polypharmacy in Primary Care (IMPPP) trial evaluated a complex, general practice-based intervention designed to reduce potentially inappropriate prescribing and improve medicines use for people living with polypharmacy. In this webinar, members of the IMPPP research team will share key findings from the trial, what worked and the challenges experienced, and how these lessons can inform future practice, service design and policy. This webinar is for everyone involved in the care of people with polypharmacy in primary care, including patients, primary care practitioners, commissioners, policy makers and researchers. Contributors: Dr Jenny Scott, Senior Lecturer & Pharmacist, Centre for Academic Primary Care, University of Bristol (Chair) Dr Deborah McCahon, Senior Research Fellow, Centre for Academic Primary Care, University of Bristol Professor Rupert Payne, Professor of Primary Care & Clinical Pharmacology, Exeter Collaboration for Academic Primary Care, University of Exeter

The recording of our webinar 'Tackling polypharmacy in primary care: Reflecting on learning from the IMPPP clinical trial' is now available!

Contributors: @jscottuob.bsky.social (Chair), Deborah McCahon & Rupert Payne.

Watch: tinyurl.com/p9pw7zy9

@nihrspcr.bsky.social @sapc.ac.uk
#GPSky #PharmSky

Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose–mesenchymal transformation | Nature Cell Biology Although peritumoural visceral adipose tissue (tVAT) is anatomically close to tumours such as colorectal cancer, the immune landscape of this tissue and its functional contribution to tumour immunity remain poorly defined. Here, we performed single-cell RNA analysis on the tVAT from patients with colorectal cancer to map its immune landscape and observed that tVAT exhibited a highly immune-infiltrated microenvironment enriched with lymphocytes, especially tumour-specific CD8⁺ T cells. Mechanistically, tVAT competes with the tumour for these immunocytes by activating the CXCL12–CXCR4 axis to promote tumour immune escape. Moreover, tumour-derived factors induce an adipose–mesenchymal transformation process where the adipose stromal cells trans-differentiated into adipose-derived cancer-associated fibroblasts, which secrete large amounts of CXCL12 in tVAT. Clinically, targeting adipose–tumour interaction substantially enhances diagnostic and therapeutic efficacy of anti-PD-1 therapy. Thes

Colorectal cancer study finds peritumoural tissue key in immune evasion. High immune infiltration with CD8+ T cells noted. PMID:41714703, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01885-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The image features Rennebohm Hall, a modern building with large glass windows, representing the University of Wisconsin-Madison School of Pharmacy. A text overlay reads: "#6 Top Pharmacy School in the Nation, U.S. News & World Report."

The UW–Madison School of Pharmacy has achieved its highest-ever ranking — #6 nationally — in the 2026 @usnews.com #pharmacy school rankings!

The School is 1 of just 4 programs in the country to maintain a Top 10 standing for 25 years running. #OnWisconsin! https://bit.ly/4cvORlT #PharmSky #PharmEd

Interested in publishing or reading research articles pertinent to Clinical Pharmacology? This editorial, from JPET's editor-in-chief Beverley Greenwood-Van Meerveld and associate editor Giorgio Minotti, explains the journal's newest section: https://ow.ly/LYbS50YF0Mq
#pharmsky 🧪

https://doi.org/10.1126/science.adv8275 No description available

Protein and genomic models achieve 99% precision, 92% recall in predicting antiphage systems, revealing 12 new ones in Escherichia & Streptomyces. PMID:41926572, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adv8275 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamadermatol.2025.5354 No description available

A woman in her 30s developed melanoma linked to a BAP1-inactivated melanocytic tumor. What's next in understanding genetic risks? PMID:41848722, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2025.5354 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1093/nar/gkag153 No description available

Dissecting yeast RNA polymerase I: Integrating biochemistry, biophysics & dynamics to unveil transcription initiation's quantitative landscape. PMID:41732916, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag153 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Harnessing glucocorticoid receptor antagonism to enhance the efficacy of cardiac regenerative growth factors and cytokines | Nature Cardiovascular Research Myocardial injuries lead to cardiomyocyte loss and heart failure. Endogenous glucocorticoids, via the glucocorticoid receptor (GR), limit cardiomyocyte regeneration. Here we show that glucocorticoids suppress mammalian (murine) cardiomyocyte proliferative response to regenerative growth factors and cytokines. GR activation in neonatal cardiomyocytes upregulated MAPK–ERK inhibitors ERRFI1 and DUSP1. Using neuregulin 1 as a model, we demonstrated that glucocorticoids inhibit growth-factor-induced ERK activation, nuclear translocation and transcriptional output. Errfi1 and Dusp1 knockdown restored growth-factor-induced proliferation of glucocorticoid-exposed cardiomyocytes. Cardiac expression of DUSP1 and ERRFI1 increased postnatally, coinciding with regenerative capacity decline. In juvenile and adult cardiomyocytes, regenerative growth factors failed to induce the MAPK–ERK pathway and proliferation; however, DUSP1 inhibition restored these responses. GR antagonism enhanced growth-factor

Unlock heart healing! Glucocorticoid receptor (GR) blockage boosts heart cell regeneration via growth factors like Neuregulin1. PMID:41652035, Nat Cardiovasc Res 2026 https://doi.org/10.1038/s44161-026-00776-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Andersen et al. quantitatively determined the efficiencies of 3 major RNases in various rat tissues and subcellular fractions in metabolizing RNAs, enabling the development of new RNA therapeutics. Read DMD's Editor's Choice to learn more: https://ow.ly/hGkp50YEFUj
#pharmsky 🧪

#Medsky🧪 #Neurosky #pharmsky #microsky #publichealth
This study identified a "drug–microbiome–drug interaction" where COMT inhibitors (like #entacapone) can counterproductively hinder the efficacy of levodopa by altering the #gutmicrobiome in #Parkinsonsdisease

https://doi.org/10.1038/s41586-026-10176-5 No description available

Evo 2. advances biological design by learning from genomes across all life. Transform insights with AI for smarter genomic editing and synthesis. PMID:41781614, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10176-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The glomerular endothelial glycocalyx as a therapeutic target in proteinuric kidney disease | Nature Reviews Nephrology Endothelial glycocalyx lines every blood vessel throughout the body, and has key roles in vascular biology, including vascular permeability and inflammation. Accumulated evidence from the past 15 years shows that the glomerular endothelial glycocalyx is a vital component of the glomerular filtration barrier, which limits the filtration of macromolecules such as albumin. However, the contribution of endothelial glycocalyx to the pathogenesis of proteinuria and its potential as a therapeutic target have not been fully explored. Experimental disruption of the glomerular endothelial glycocalyx increases glomerular albumin permeability, and loss of endothelial glycocalyx integrity has been observed in diseases that compromise the glomerular filtration barrier, including diabetic kidney disease and other glomerular diseases. Strategies to protect the endothelial glycocalyx have successfully reduced proteinuria in animal models of proteinuric kidney disease, indicating that therapeutic modifi

Discover how the glomerular endothelial glycocalyx, crucial for vascular permeability, may be key in treating proteinuria! PMID:41272309, Nat Rev Nephrol 2026, @NatRevNeph https://doi.org/10.1038/s41581-025-01028-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1038/s41569-026-01255-1 No description available

Organ-on-a-chip tech is a game-changer for cardiovascular research, beating limits of in vitro & animal models with 3D structures. PMID:41673471, Nat Rev Cardiol 2026, @NatRevCardiol https://doi.org/10.1038/s41569-026-01255-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A woman pointing at another woman’s shirt which reads “Who is Dr. Hirsch anyway? Ew.”

POV: you show up to teach class the hour after your former ID course co-director @draphilbrick.bsky.social , a fellow Swiftie, and last year you made your course TS themed. Pretty good TS-themed trolling here🤩

#UMNPharmacy #Pharmsky #TaylorSwift

#Medsky🧪 #IDsky #pharmsky #publichealth @emjreviews.bsky.social
Fluvoxamine ( Luvox) has recently been shown to significantly reduce fatigue & improve QoL of in adults with #longCOVID but it Not a Universal Cure - LC is complex & involves multiple symptoms & this study focused primarily on fatigue

Kevin's story: community pharmacists are part of the solution Kevin's experience as Director of Pharmacy Operations at a community pharmacy helps him recognize the signs of someone struggling with costs.

#Pharmacists are key in helping patients understand & manage their health, especially when cost is a barrier. Kevin sees the signs every day: patients who ask to return after their next paycheck, or medications left on the shelf because someone can't afford them: https://bit.ly/41aZNz5 #PharmSky

https://doi.org/10.1038/s41467-026-68972-6 No description available

Discover how 1,089 proteins link pollutants to diseases. Study reveals 30 health risks tied to air pollution. Dive into the UK Biobank data for insights! PMID:41620459, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-68972-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 | Nature Cell Biology Pattern recognition receptor (PRR)-induced interferon (IFN) is critical for effective immunity. The PRRs Toll-like receptor (TLR) 3, TLR4 and cyclic GMP–AMP synthase (cGAS), together with the stimulator of IFN genes (STING), signal through TANK-binding kinase 1 (TBK1), which activates the type-I/III IFN-inducing transcription factor interferon-response factor 3 (IRF3). The mechanism by which these PRRs activate TBK1 remains unresolved. Here we show that lysine-11 (K11)-linked ubiquitination drives TBK1 activation by these PRRs. The E3 ligase ANKIB1 attaches K11-linked ubiquitin chains to components of the TLR3- and cGAS–STING-induced signalosomes. This facilitates Optineurin recruitment to these complexes, in turn enabling recruitment and activation of TBK1 and IRF3, defining an uncharacterized signalling axis. In mice, ANKIB1 deficiency dampens IFN induction via TLR3 and cGAS–STING, reducing interferonopathy and compromising protection against HSV-1, respectively. Together, our result

K11-linked ubiquitination activates TBK1, driving type-I/III IFN induction via cGAS-STING, TLR3, and TLR4 pathways. Key PRR strategy! PMID:41792265, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01886-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Entorhinal cortex represents task-relevant remote locations independently of CA1 | Nature Neuroscience Neurons can collectively represent the current sensory experience during exploration or remote experiences during immobility. Remote representations can reflect learned associations and support learning. Neurons in medial entorhinal cortex (MEC) represent the animal’s current location during movement, but little is known about MEC representations during immobility. We recorded hundreds of neurons simultaneously in MEC and CA1 as mice learned to associate pairs of rewarded locations. During immobility, the MEC neural population frequently represented positions far from the animal’s location (‘nonlocal coding’). Cells with spatial firing fields at remote locations drove nonlocal coding, even as cells representing the current position remained active. While MEC nonlocal coding has been reported during sharp-wave ripples in CA1, we observed nonlocal coding more often outside of ripples and saw less CA1–MEC coordination during nonlocal coding. Further, nonlocal coding preferentially represe

MEC neurons represent remote locations during immobility independently of CA1. Crucial for learning location pairs in tasks. #Neuroscience PMID:41922514, Nat Neurosci 2026, @NatureNeuro @Stanford https://doi.org/10.1038/s41593-026-02232-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://www.cell.com/cell/fulltext/S0092-8674(25)01502-8 No description available

PDA cells modulate autophagy via ECM sensing through the α3 integrin-Hippo-YAP1 axis, highlighting a novel pathway in tumor heterogeneity regulation. PMID:41702399, Cell 2026, @Cell www.cell.com/cell/fulltext/S0092-8674... #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1093/nar/gkag260 No description available

Discover how 7 DNA repair patterns guide CRISPR outcomes! Dive into genome-wide networks with indel pattern-guided insights. PMID:41891877, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag260 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamapsychiatry.2026.0246 No description available

Delve into ethical dilemmas of RDD trials for stopping opioid use disorder meds. Key insights from JAMA Psychiatry. PMID:41848706, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.0246 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1093/nar/gkag167 No description available

CRISPR-Cas12a activity enhanced! Reversible crRNA scaffold remodeling via short DNA blockers boosts precision and control. PMID:41784267, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag167 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1038/s41586-026-10224-0 No description available

Detect disease origins and therapy responses from just 50μl of plasma with cf-EpiTracing! Profiles histone mods, integrates chromatin states, uses AI. PMID:41781618, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10224-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Quality-oriented diet therapy for chronic kidney disease | Nature Reviews Nephrology Traditional dietary advice for people living with chronic kidney disease (CKD) focused predominantly on the quantity of energy and protein provided by the diet as well as restricting the consumption of single micronutrients. However, flaws in the assumptions that underlie this quantity-based approach have led to re-examination of medical nutrition therapy for kidney-related conditions, with a shift towards recommending more varied and liberalized plant-rich diets with a focus on dietary quality. Although clinical practice guidelines for patients with CKD have cautiously acknowledged this shift, less advice is available on how to translate new knowledge into practical and feasible recommendations that describe which foods patients should be advised to eat. In this Review, we provide a framework for the delivery of quality-oriented diet therapy for people with CKD based on the dietary principles of balance, variety and moderation. This approach also requires consideration of the manner i

Revised CKD diet therapy: Move from rigid nutrient limits to diverse, plant-rich focus for improved nutrition quality! PMID:41491876, Nat Rev Nephrol 2026, @NatRevNeph https://doi.org/10.1038/s41581-025-01034-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪