Post-pandemic changes in population immunity have reduced the likelihood of emergence of zoonotic coronaviruses | Nature Communications Infections by endemic viruses, and the vaccines used to control them, often provide cross-protection against related viruses, potentially altering the transmission dynamics and likelihood of emergence of new zoonotic viruses with pandemic potential. Here, we investigate how population immunity after the COVID-19 pandemic has impacted the likelihood of emergence of a novel sarbecovirus, termed SARS-CoV-X. To this end, we combined empirical cross-neutralisation data with mathematical modelling to identify key immunological and epidemiological factors shaping sarbecovirus emergence. We show that sera from individuals with different COVID-19 immunological histories contained cross-neutralising antibodies against the spike (S) protein of multiple zoonotic sarbecoviruses. Simulations parameterised by these data predict that the likelihood of emergence of a novel sarbecovirus has been reduced significantly by population cross-immunity, with outcomes determined by the extent of cross-protectio

Post-COVID population immunity lowers new zoonotic coronavirus risk. Study: Cross-neutralization data + models show reduced SARS-CoV-X threat. PMID:41876522, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-69988-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation | Nature Chemical Biology Subcellular stress profoundly influences protein synthesis. However, both the nature of spatiotemporally restricted chemical cues and local protein responders to these cues remain elusive. Unlocking these mechanisms requires the ability to functionally map in living systems locale-specific stress responder proteins and interrogate how chemical modification of each responder impacts proteome synthesis. We resolved this problem by integrating precision localized electrophile generation and genetic code expansion tools. Upon examination of four distinct subcellular locales, only nuclear-targeted electrophile stress stalled translation. We discovered that NCBP1—a nuclear-resident protein with multifaceted roles in eukaryotic mRNA biogenesis—propagated this nuclear stress signal through a single cysteine (C436) from among its 19 conserved cysteines. This NCBP1(C436)-specific modification elicited alternative splicing of more than 250 genes. Mechanistically, global protein synthesis stall wa

NCBP₁ stress signaling alters S6K₁ splicing, hindering translation. Researchers integrated localized electrophile methods. PMID:41667655, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-025-02135-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-κB p65 subunit to drive cardiac inflammation and remodeling | Nature Communications Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remodeling in terminally differentiated cardiomyocytes. Firstly, kinase enrichment analysis and experimental evidence revealed CDK9 phosphorylation at Thr-186 in both human and mouse hypertrophic heart tissues. CDK9 loss of function via T186A mutation in cardiomyocytes attenuated Ang II-induced heart remodeling and NF-κB-mediated inflammation, whereas CDK9 overactivation by T186E mutation induces. This regulatory function of CDK9 in cardiac remodeling is cell cycle-independent. Further studies demonstrate that the kinase domain of CDK9 directly binds to NF-κB P65 protein, which leads to the CDK9/P65 complex nuclear translocation, P65 phosphorylation, and transcription of inflammatory and hypertr

CDK9 phosphorylates NF-κB p65 in cardiomyocytes, fueling inflammation and remodeling in hypertensive heart failure. Potential target: Thr-186 site. PMID:41876530, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70410-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://www.cell.com/cell/fulltext/S0092-8674(25)01495-3 No description available

EBV alters the transcriptome and immunopeptidome in HLA-DR15+ B cells, enhancing myelin peptide presentation, potentially driving MS pathogenesis. PMID:41534530, Cell 2026, @Cell www.cell.com/cell/fulltext/S0092-8674... #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Proteomic landscape of Ewing sarcoma primary tumors and metastases | Nature Communications Ewing sarcoma (EWS), a rare pediatric bone tumor, poses unique therapeutic challenges due to its distinct microenvironment and limited molecular understanding. To gain a comprehensive molecular and functional view of the tumors in their microenvironment, we perform a deep mass spectrometry-based proteomic analysis of 170 tumor samples from 74 patients from primary, relapsed, and metastatic tumors. Analysis of more than 10,000 proteins across patients reveals insights into cancer prognosis, chemo-resistance, and progression. Our analyses suggest that ferroptosis pathways may be associated with chemotherapy response in EWS, and we delineate molecular subclasses that correlate the tumor immune landscape with DNA damage repair, ubiquitin-related proteins, and patient outcomes. Multiplexed immunofluorescence imaging indicates possible associations between neutrophils and poorer prognosis, and between macrophages/T cells and a more favorable prognosis. Altogether, this investigation provides

Ewing sarcoma proteomics: 10,000+ proteins studied in 170 tumor samples from 74 patients, offering key insights into prognosis and chemoresistance. PMID:41813675, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70449-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine | Nature Chemical Biology Biomolecular condensates are membraneless bodies that organize biochemical reactions typically within cells. However, the roles of condensates in extracellular space—where conditions differ substantially from intracellular space—remain poorly understood. Here we report that mast cell extracellular granules (MCEGs), a stable membraneless entity, are condensates assembled through electrostatic interactions between glycosaminoglycans and polyamines. Disrupting polyamine synthesis or trafficking blocks MCEG formation and compromises the storage of proteases and cytokines. Granules reconstituted with heparin and spermine are sufficient to enrich mediators such as carboxypeptidase A3 (CPA3) and tumor necrosis factor (TNF), maintaining an elevated pH and higher concentrations of calcium and zinc compared to the extracellular milieu. This unique environment enhances CPA3 enzymatic activity. Furthermore, the granules increase TNF binding and its bioactivity toward endothelial cells. Together, w

Mast cell extracellular granules (MCEGs) are bioactive condensates formed by heparin and polyamines, crucial for immune responses. PMID:41760814, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02165-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1126/science.aea1820 No description available

Discover MULTI-evolve: a rapid evolution method efficiently engineering protein multimutants using AI. Transform lengthy, costly trials! PMID:41712694, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aea1820 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RNA-specific local translation is patterned by condensates for multinucleate cell growth | Nature Cell Biology Coordination between growth and nuclear division is a common cell feature. In some syncytia, nuclei divide asynchronously throughout the cell but growth occurs only at discrete locations, raising the question how the processes are locally regulated and globally coordinated. In the syncytial fungus Ashbya gossypii, both cell cycle progression and hyphal elongation require condensates formed by the protein Whi3 in complex with distinct mRNA species. Here we show that Whi3 condensates are enriched for translation regulators and are associated with local, spatially patterned translation of specific target RNAs near nuclei and growth sites. Whi3–RNA condensates can both promote and repress mRNA translation in an RNA- and condensate size-dependent manner in vitro. Condensate interfaces are sites of translation, tunable by condensate composition, RNA valency and protein charge state in vitro. Together, these data suggest that Whi3 condensates can generate a continuum of translation states tha

In Ashbya gossypii, Whi3 protein forms RNA condensates to synchronize nuclear division and growth in multinucleate cells. PMID:41772090, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01887-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamadermatol.2026.0181 No description available

Discover the promise: Intralesional interleukin-2 therapy shows potential in treating high-risk or sensitive cSCC cases! 🎯📊 PMID:41848721, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.0181 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heterogeneity in lysosomal dynamics and metabolic functions along the kidney proximal tubule | Nature Communications The kidney proximal tubule is a highly specialized epithelium that transports metabolites and maintains body homeostasis. Cells lining this nephron segment are densely packed with lysosomes, but little is known about the dynamic activity of these organelles in situ. Here, using targeted sensors and live cell and intravital imaging we track acidified lysosomes along the mouse proximal tubule and uncover marked axial heterogeneity in their distribution, characteristics and organellar interactions. In the early part, cathepsin-rich lysosomes frequently contact with apical endosomes to receive and catabolize filtered plasma proteins. Conversely, in the later region, lipase-containing lysosomes traverse cells to mobilize and degrade mitochondria-associated lipid droplets and facilitate their extrusion into the tubular lumen. Acutely de-acidifying lysosomes dramatically alters their movement, causing major changes in tubular protein and lipid processing. Thus, lysosomes in proximal tubules a

Kidney proximal tubule lysosomes show dynamic, axial heterogeneity revealed via live imaging—marked differences in distribution and interactions observed.🚀 PMID:41803103, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70306-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Omics. Regulation. AI.
Explore how integrative genomics and machine learning are redefining cardiovascular research at the Omics, Regulation, & AI for Precision Cardiovascular Medicine virtual symposium, April 28–29. 👉Register now: https://bit.ly/41wDRyt #CardioGenomics #VirtualSymposium #ASHG

https://doi.org/10.1093/nar/gkag226 No description available

Genome-wide CRISPR screens reveal the EXO1-CAF-1 pathway mitigates R-loop DNA damage, critical for repair and cisplatin response. PMID:41841497, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag226 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Magnaporthe oryzae MoPh1 perceives ER stress and promotes adaptive responses via a plasma membrane-to-vacuole pathway | Nature Communications During growth and development, cells experience both internal and external stresses, which can exert harmful impacts if they are poorly managed. Endoplasmic reticulum (ER) stress is an internal stress that is induced when protein misfolding or perturbations occur at excess rates, and the conventional response pathways from the ER to the nucleus are activated to address the stress. However, the involvement of the plasma membrane (PM) system in response to this internal stress has been insufficiently investigated. Here, a PM sensor, MoPh1, was observed to perceive stress through ER-PM contact sites and target the autophagosome and vacuole, consequently stimulating the autophagy process and supporting stress relief. The PM-to-vacuole pathway mediated by MoPh1 is independent of the classical ER-to-nucleus pathway and might be highly important in both fungi and plants, as it plays a crucial role in alleviating ER stress and promoting cellular adaptation for cell survival. The unfolded prote

Discovery: Magnaporthe oryzae MoPh1 detects ER stress and boosts adaptive responses via a novel plasma membrane-vacuole route, enhancing stress management! PMID:41839901, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70610-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1126/science.adr4661 No description available

Study in Science: Myelin in zebrafish and rodents swells before damage but can recover via remodeling. High neuron activity worsens damage. PMID:41678629, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adr4661 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The American Journal of Human Genetics (@ajhgnews.bsky.social) https://www.cell.com/AJHG/home

Authors of @ajhgnews.bsky.social's latest article expand the phenotypic spectrum of RNU4ATAC-associated disorders by showing that bi-allelic variants in the minor spliceosome snRNAs RNU6ATAC & RNU4ATAC cause early-onset autoimmune diabetes with immune dysregulation: https://bit.ly/40MZmLd #ASHG

Through a community-based participatory research approach, @hggadvances.bsky.social's latest article aims to identify barriers & actionable strategies to improve genetic testing completion offered through the Breast Health Assessment: https://bit.ly/4t6uilG #ASHG #HumanGenetics #GeneticsDiscoveries

https://www.cell.com/ajhg/fulltext/S0002-9297(26)00070-4 No description available

Breakthrough in detecting de novo variants: duoNovo identifies them in 1 parent & proband; 104 trios sequenced with PacBio HiFi! #Genetics PMID:41795468, Am J Hum Genet 2026, @AJHGNews www.cell.com/ajhg/fulltext/S0002-9297... #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamadermatol.2026.0001 No description available

Stage I-II melanoma recurrence risk linked to factors beyond ulceration & thickness. Important for patient surveillance & counseling. PMID:41779403, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.0001 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Quantitative analysis of small RNA pseudouridylation reveals interplay of PUS enzymes in tRNA anticodon stem-loop | Nature Communications Pseudouridine (Ψ) is an abundant modification in small RNA catalyzed by multiple pseudouridine synthases (PUSs). However, the substrate specificity of human PUSs remains elusive. Here, we adopted PRAISE, a quantitative Ψ detection method, to profile pseudouridylation in small RNA, including cytosolic and mitochondrial tRNAs, snRNA, and snoRNA. We found that snoRNA pseudouridylation is mediated not only by RNA-guided DKC1, but also by the stand-alone enzyme PUS7 at a specific site. Interestingly, several PUS enzymes, including PUS1, RPUSD1, and PUS7, which install nearby Ψ sites within tRNA anticodon stem-loop, can influence pseudouridylation catalyzed by other PUSs, revealing an unrecognized interplay during Ψ formation. For the three RluA family enzymes, RPUSD1 catalyzes the canonical Ψ30 in tRNA-Ile and Ψ72 in tRNA-Arg isoacceptors. RPUSD2 pseudouridylates Ψ31 of mt-tRNALeu(CUN), Ψ32 of mt-tRNAPro and mt-tRNACys, whereas RPUSD3 lacks tRNA activity. Together, our quantitative Ψ profil

Discover how pseudouridine (Ψ) tweaks small RNA! A study using PRAISE shows snoRNA gets pseudouridylation via DKC1 and PUS7, revealing PUS enzyme teamwork. PMID:41698914, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-69177-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A red/blue optoswitch for temporal control of chloroplast transcription and biogenesis in Arabidopsis | Nature Communications Photosynthesis genes in plant chloroplasts are transcribed by the plastid-encoded RNA polymerase called PEP. Consequently, PEP-deficient mutants cannot generate a photosynthetic apparatus and develop non-viable albino seedlings. Inducible complementation of such mutants thus could provide interesting insights in PEP action and chloroplast biogenesis. Here we show the effects of photo-inducible complementation in the albino Arabidopsis mutant pap7-1 using a red/blue optoswitch with monochromatic LEDs. Expression of a blue-light-induced PAP7 construct that is silent under red light reconstitutes PEP at any time point of pap7-1 development resulting in proper chloroplast biogenesis that rescues the non-viable mutant. Induction of chloroplast biogenesis, however, can only occur in very young leaf tissues indicating the existence of a cell-autonomous, biogenic coupling between cell and organelle development. We further uncover that initial PEP formation and function is independent of photos

Revealed: Red/blue optoswitch rescues albino mutant Arabidopsis pap7-1 by regulating chloroplast transcription. Discoveries in PEP action and biogenesis! PMID:41720790, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-69626-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamadermatol.2025.4860 No description available

Case of #MulticentricReticulohistiocytosis: extensive erythema (face, chest, back) & swollen hands with papules/nodules observed. PMID:41637085, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2025.4860 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1056/NEJMoa2508515 No description available

Phase 3 trial: Tenecteplase 0.25 mg/kg vs placebo in central retinal artery occlusion (within 4.5h onset). Could change vision loss treatment! PMID:41604638, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2508515 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1056/NEJMoa2514824 No description available

Adenoviral vectors in COVID-19 vaccines can trigger rare VITT. Study reveals antibody mutations in response to PF4 complex. Insights into VITT needed! PMID:41671482, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2514824 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1126/science.adr4287 No description available

Stressed cells form inactive ribosome clusters, disomes, via rRNA ES31Lb. Observed with cryo-ET: crucial for conservation. PMID:41712727, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adr4287 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

Introducing CRI-SPA-Map: A new tool for pinpointing genetic variation in S.cerevisiae using CRISPR, SPA, and high-throughput phenotyping. PMID:41871879, Genome Res 2026 @OTSociety @NAR_Open https://doi.org/10.1101/gr.281514.125 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

NCX1 reverse mode promotes calcium-dependent Neutrophil Extracellular Trap formation and lung damage in chronic obstructive pulmonary disease | Nature Communications Neutrophil-driven inflammation is central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Emerging evidence suggests that Ca²⁺ signaling is critical in regulating neutrophil activation, recruitment and tissue residency. In this study, we investigated the function of Na⁺/Ca²⁺ exchanger 1 (NCX1), a Ca²⁺/cation membrane transporter, in neutrophils during COPD pathogenesis. Analysis of human specimens show that NCX1 is primarily upregulated in neutrophils from patients with mixed chronic bronchitis and emphysema. Cigarette smoke exposure induces NCX1 upregulation and promotes its reverse-mode transport activity, leading to elevated intracellular Ca²⁺ levels and enhanced NETs formation. Neutrophil-specific genetic deletion of Slc8a1 or pharmacological inhibition of NCX1 reverse transport effectively suppresses Ca²⁺ influx, NETs release, and neutrophil accumulation and retention, thereby ameliorating chronic bronchitis and emphysematous changes. Collectively, our finding

New study: NCX1 reverse mode significantly boosts Ca²⁺-linked NETs formation and lung damage in COPD. Key role in neutrophil-driven inflammation unveiled. PMID:41813659, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-69636-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Photosensitizer proximity labeling captures the lipid and protein interactomes | Nature Chemical Biology The physical properties of cellular membranes are influenced by protein and lipid interactions. In situ proximity labeling interactomic methods are well suited to characterize these dynamic and often fleeting interactions. Yet, available methods require distinct chemistries for proteins and lipids. Here we establish a singlet oxygen-based photocatalytic proximity labeling platform (POCA) that reports intracellular interactomes for both proteins and lipids using cell-penetrant photosensitizer reagents. Cholesterol-directed POCA captured known and unprecedented cholesterol-binding proteins, including protein complexes sensitive to intracellular cholesterol levels and proteins uniquely captured by physiologically relevant lipoprotein uptake. Protein-directed POCA accurately mapped intracellular membrane complexes, defined sterol-dependent changes to the interactome of the cholesterol transport protein Aster-B and revealed singlet oxygen-mediated domain-specific Aster crosslinking. More br

New study reveals POCA method for dual protein & lipid interactome mapping using a single singlet oxygen photosensitizer! PMID:41652064, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02140-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Post-infection sequelae of COVID-19 and other infectious diseases—a nationwide Danish study with 40-month follow-up | Nature Communications Nationwide follow-up studies of long-term post-acute COVID-19 sequelae compared with sequelae of other infections have been lacking. Using nationwide registers, we analyzed all SARS-CoV-2 PCR test results, prescriptions for anti-infective agents, and hospitalizations with COVID-19 or other infections in Denmark from March 2020 to June 2023, including up to 40-month follow-up. We used Cox proportional hazards models with time-varying exposures to estimate the rates of first-time mental disorders (n = 5,306,132) and general medical conditions (n = 3,517,630). Here we show that positive SARS-CoV-2 PCR tests alone were not associated with clinically relevant increased rates of mental disorders or general medical conditions when compared with negative SARS-CoV-2 PCR tests, nor when compared to individuals with anti-infective prescriptions. Rates of general medical conditions after a positive compared with a negative SARS-CoV-2 PCR test were only elevated for virus types preceding Omicron an

Danish study tracks post-COVID effects vs. other infections over 40 months. Analyzes 3 years of data from March 2020. Key insights on infection impacts. PMID:41826293, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70351-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1126/science.aeb3295 No description available

Implanted stretchable electronics track cell maturity in pancreatic organoids, showing months-long improved hormone response in SC-α/β cells! PMID:41712726, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aeb3295 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1056/NEJMcp2506817 No description available

Polymyalgia rheumatica hits those over 50, causing shoulder pain and morning stiffness. Diagnosis: elevated ESR, CRP. Glucocorticoids help. PMID:41812194, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMcp2506817 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪