- #entacapone acts by chelating (binding) iron, effectively "starving" some microbes of this essential nutrient.
- As sensitive bacteria die off, other strains like Enterococcus faecalis can thrive.

#Medsky🧪 #Neurosky #pharmsky #microsky #publichealth
This study identified a "drug–microbiome–drug interaction" where COMT inhibitors (like #entacapone) can counterproductively hinder the efficacy of levodopa by altering the #gutmicrobiome in #Parkinsonsdisease

We further demonstrate that #entacapone treatment selects for potentially pathogenic microbes well adapted to iron limiting conditions.