#ACAT1 acquires a nuclear role in #ColorectalCancer, where S60 phosphorylation enables p50 acetylation, relieves #NFκB repression, enhances #NKcell recruitment, while nutrient stress blocks this axis and drives #ImmuneEvasion and poor prognosis.

#STTT: doi.org/10.1038/s413...

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

👉 buff.ly/AOrrON6

#p21 #ColonCancer #Stemness #NFκB

A recent study shows that serum #Midkine suppresses #OsteoblastDifferentiation via the #PI3K-AKT pathway and increases #Inflammatory #Cytokines via the #NFκB pathway, promising a therapeutic target for postmenopausal #Osteoporosis. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study shows that #Peritoneal #AdiposeDerivedStemCells orchestrate #disease progression and #Metastasis in #OvarianCancer through #ExtracellularVesicle-mediated, long-range modulation of #EGFR and #NFκB signaling pathways. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study from @fudan-university.bsky.social identifies oral Z526 as a promising anti-CAC agent that targets #NFκB signaling and #OxidativeStress, offering new hope for cancer-associated #Cachexia therapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This study identifies #FSP1 as a key promoter of #IntervertebralDiscDegeneration (IDD) through #TNFα-reliant #NFκB signaling and #Caspase3-dependent #Apoptosis, positioning FSP1 as a novel #therapeutic target for IDD. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

New Spotlight alert! #REL2 #NFκB pathway modulates #midgut #bacterial #homeostasis in #Anopheles #gambiae, authored by Yanhong Wang & Zhen Zou, highlighting a @cp-cellreports.bsky.social article by Elena Levashina & @mpiib-berlin.mpg.de colleagues. #malaria

authors.elsevier.com/a/1lqM65Eb1x...

Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response Effector-triggered immunity (ETI) is a form of pathogen sensing that involves detection of pathogen-encoded virulence factors or 'effectors'. To discover novel ETI pathways in mammals, we developed a ...

Today in #preprinthub2 Lisabeth Pimenov will present a #preprint from Russell Vance & Moritz Gaidt on how a #poxvirus attack of anti-viral defense pathways unleashes an effector-triggered #NFκB response 🦠🚨🥷🏻

www.biorxiv.org/content/10.1...

Inactivated SARS-CoV-2 induces acute skeletal muscle damage in human K18-hACE2 transgenic mice The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in over 7 million global fatalities and billions of individu…

www.sciencedirect.com/science/arti...

"Significant elevations were noted in inflammatory mediators in the muscle of inactivated #SARSCoV2 mice, including high mobility group box-1, tumor necrosis factor-alpha, phospho-nuclear factor kappa B, caspase 11, and pannexin-1." #HMGB1 #TNFα #NFκB #PANX1