Intracellular PANX1 distributes to macropinosomes. (A) Representative confocal micrographs with line scan over ROI demonstrate PANX1 localization in membrane-like structures surrounding macropinosome cargo 70 kDa dextran-TRITC. Inset highlights putative PANX1-positive macropinosome.

Andrew Boyce & co show that elevated extracellular ATP drives a macropinocytosis- and pannexin 1-mediated increase in neuroblastoma cell size. doi.org/10.1242/bio....

#Pannexin #PANX1 #Macropinocytosis #ATP

Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice Previous studies have suggested a significant role of pannexin 1 (Panx1)/P2X7 receptor complex in cardioprotective mechanism of ischemic preconditioni…

Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice #MECFS #LongCovid #PANX1 #P2X7 #SARSCoV2

www.sciencedirect.com/science/arti...

Changes in the Pannexin Channel in Ileum Myenteric Plexus and Intestinal Motility Following Ischemia and Reperfusion #PANX1 #Probenecid #MECFS #LongCovid

bsky.app/profile/rene...

Changes in the Pannexin Channel in Ileum Myenteric Plexus and Intestinal Motility Following Ischemia and Reperfusion After Ileum ischemia/reperfusion damage, injury neurons release extracellular ATP which can act both autocrine and paracrine by the activation of P2X7 receptor. The pannexin channel blockage by probe...

onlinelibrary.wiley.com/doi/abs/10.1...

"Probenecid (PB) is a pannexin-1 channel inhibitor, which can be a potential treatment for intestinal ischemia." #PANX1

"The analysis of the contraction after electrical simulation was lower in the I/R 14 d group and recovered in the PB 14d."

Changes in the Pannexin Channel in Ileum Myenteric Plexus and Intestinal Motility Following Ischemia and Reperfusion After Ileum ischemia/reperfusion damage, injury neurons release extracellular ATP which can act both autocrine and paracrine by the activation of P2X7 receptor. The pannexin channel blockage by probe...

onlinelibrary.wiley.com/doi/abs/10.1...

"Intestinal ischemia affects the functioning of the Enteric Nervous System (ENS)."

"Pannexin-1 channel participates in cell communication and extracellular signaling." #PANX1

Changes in the Pannexin Channel in Ileum Myenteric Plexus and Intestinal Motility Following Ischemia and Reperfusion After Ileum ischemia/reperfusion damage, injury neurons release extracellular ATP which can act both autocrine and paracrine by the activation of P2X7 receptor. The pannexin channel blockage by probe...

Changes in the Pannexin Channel in Ileum Myenteric Plexus and Intestinal Motility Following Ischemia and Reperfusion #PANX1 #Probenecid #MECFS #LongCovid

onlinelibrary.wiley.com/doi/abs/10.1...

Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock The noncanonical inflammasome induced by intracellular lipopolysaccharide (LPS) leads to caspase-11-dependent pyroptosis which is critical for induction of endotoxic shock in mice. However, the signal...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"ATP release and pyroptosis induced by LPS transfection were effectively inhibited by carbenoxolone (CBX), probenecid and trovafloxacin, three inhibitors of pannexin-1, a plasma membrane channel that facilitates ATP export." #PANX1

Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock The noncanonical inflammasome induced by intracellular lipopolysaccharide (LPS) leads to caspase-11-dependent pyroptosis which is critical for induction of endotoxic shock in mice. However, the signal...

Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock #PANX1

pmc.ncbi.nlm.nih.gov/articles/PMC...

Inactivated SARS-CoV-2 induces acute skeletal muscle damage in human K18-hACE2 transgenic mice The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in over 7 million global fatalities and billions of individu…

www.sciencedirect.com/science/arti...

"Significant elevations were noted in inflammatory mediators in the muscle of inactivated #SARSCoV2 mice, including high mobility group box-1, tumor necrosis factor-alpha, phospho-nuclear factor kappa B, caspase 11, and pannexin-1." #HMGB1 #TNFα #NFκB #PANX1