Here you can see a cryoEM structure of human pannexin 3 (PDB code: 9JCH)

Rendering by Francisco J. Enguita made with #ProteinImager

#SciArt #molecularart #pannexin #cryoem #mediator #linker #response

Intracellular PANX1 distributes to macropinosomes. (A) Representative confocal micrographs with line scan over ROI demonstrate PANX1 localization in membrane-like structures surrounding macropinosome cargo 70 kDa dextran-TRITC. Inset highlights putative PANX1-positive macropinosome.

Andrew Boyce & co show that elevated extracellular ATP drives a macropinocytosis- and pannexin 1-mediated increase in neuroblastoma cell size. doi.org/10.1242/bio....

#Pannexin #PANX1 #Macropinocytosis #ATP

Panx1a modulates metabolic stress signaling and synaptic composition in the developing zebrafish brain - Cell and Tissue Research Pannexin 1a (Panx1a), a neuronal ATP-release channel, is increasingly recognized for its role in neurodevelopment, yet its contribution to synaptic homeostasis under metabolic stress remains poorly de...

Members of my team report that loss of Panx1a exacerbates mitochondrial dysfunction, disrupts ATP signaling, activates stress pathways like AMPK–mTORC1, and impairs synaptic integrity, leading to increased neuronal cell death and altered network activity #zebrafish #pannexin doi.org/10.1007/s004...

Summary Intestinal ischemia and reperfusion causes intestinal damage as a whole. Here, we demonstrate that this condition also affects enteric neurons that control intestinal motility. The pannexin-1 channel is a membrane protein important in cellular communication and also in controlling ATP levels. In this work, we treated animals subjected to ischemia and reperfusion with probenecid, a pannexin-1 inhibitor. PB was able to attenuate the harmful effects of I/R, recovering the number of enteric neurons and improving intestinal motility.

🆕🔥 #NGMJournal
✳️Changes in the #Pannexin Channel in Ileum Myenteric Plexus & Intestinal Motility Following Ischemia & Reperfusion‼️
🎯Pannexin channel blockage by probenecid is effective in attenuating the effects of I/R damage👏
👉 onlinelibrary.wiley.com/doi/full/10....
#ANMS #ESNM