Key Points The distal colon has a natural “brake” (the rectosigmoid brake) that controls how quickly stool enters the rectum, helping prevent urgency and maintain continence. When this brake misfires, different problems can result: after colorectal surgery it may become overactive and delay recovery; when weakened or removed it can lead to urgency or incontinence. This brake is a promising, measurable sign to guide care: it can be boosted by sacral nerve stimulation, and new non-invasive tests may help doctors track it to predict recovery and tailor treatment.

🆕🔥Colonic motility #mapping reveals a meal-induced #RectosigmoidBrake in healthy individuals that is disrupted, disorganized, or exaggerated following #surgery & in #MotilityDisorders‼️ #ileus #PseudoObstruction #FecalIncontinence
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key Points Children with chronic abdominal pain often have trouble sleeping and we found that indicators of parasympathetic activity may be linked to nighttime sleep. Girls and boys showed different patterns of associations between heart rate variability and sleep. Sleep-disordered breathing, including snoring or gasping, was associated with lower heart rate variability in both sexes.

🆕🔥 #HeartRateVariability & #Sleep among Girls & Boys with #AbdominalPain‐related #DisordersofGutBrainInteraction‼️
🎯Sleep-disordered breathing is associated with lower #HRV in both sexes #snoring #gasping
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM @drvantilburg.bsky.social 👏

Highlights 1. α-Syn Oligomers Are the Most Neurotoxic Species β-sheet-rich α-synuclein (α-Syn) oligomers are key drivers of neurodegeneration in Parkinson's disease (PD), exhibiting greater neurotoxicity than monomers or fibrils. 2. Gut as the Origin of Pathology The intestine serves as a critical initiation site for α-Syn oligomer formation, modulated by intestinal inflammation, microbiota dysbiosis, environmental toxins, and genetic mutations. 3. Gut-to-Brain Transmission Pathways Gut-derived α-Syn oligomers propagate to the brain via multiple routes: the vagus nerve, spinal cord, systemic circulation (including exosomes), and immune cells such as CD11c⁺ phagocytes. 4. Mechanisms of Neurotoxicity α-Syn oligomers induce neuronal injury through oxidative stress, neuroinflammation, mitochondrial dysfunction, cytoskeletal disruption, and synaptic impairment. 5. Therapeutic Strategies Targeting α-Syn Oligomers Promising interventions include: inhibiting oligomer formation (e.g., Anle138b, baicalein, doxycycline); promoting α-Syn degradation via autophagy (e.g., icariin, nilotinib); blocking pathological propagation (e.g., antibodies BIIB054, MEDI1341). 6. Clinical and Translational Potential Targeting gut-derived α-Syn oligomers provides a novel early-stage strategy for PD, capable of modifying disease progression rather than merely alleviating symptoms.

🚨Fascinating Review🆕🔥
⏩Intestinal α-Syn Oligomers as a Novel Pharmacological Target for #Parkinson'sDisease‼️
🎯Novel insights into pathogenetic mechanisms👏
🎯Therapeutic feasibility of targeting gut-derived α-Syn oligomers💡
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key Points In patients with gastroparesis, the most common predominant symptoms were nausea, vomiting, and abdominal pain. Impaired QOL varied with the patient's predominant symptom, with abdominal pain associated with poorer QOL. Over 48 weeks, GSCI improved ≥ 1 in a minority of patients, more often in patients with predominant symptoms of nausea and bloating, less often for fullness and abdominal pain. The predominant symptom can change over time.

🆕🔥Predominant Symptom in Gastroparesis: #Cohort #Treatments #Outcomes‼️
🎯Most common predominant symptoms⏩#Nausea, #Vomiting & #AbdominalPain and PrS can change over time👏
🎯Abdominal pain associated with poorer QOL🔥
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM #GpCRC

🆕🔥#PercutaneousElectricalNerveFieldStimulation improves weight & other anthropometric outcomes in #Children & #Adolescents with #FunctionalDyspepsia who restrict their oral intake‼️
🎯#PENFS can improve GI symptoms & #psychosocial outcomes #DGBIs👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

🆕🔥Alternative Pathways of #Acetylcholine Release in Colon: Role of #HighAffinity Choline Transporters‼️
🎯High-affinity choline transporters provide a novel pathway for acetylcholine release originating from neuronal sources👏
#ANMS #ESNM
👉 onlinelibrary.wiley.com/doi/10.1111/...

🆕🔥Adolescent normative intervals for #BodySurfaceGastricMapping‼️
🎯BSGM normative reference intervals support test interpretation & allow specific phenotyping of gastric abnormalities & guide symptoms management👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key Points • First-line therapies for functional dyspepsia, including proton pump inhibitors and Helicobacter pylori eradication, provide limited symptom relief in a substantial proportion of patients. • Functional dyspepsia and gastroparesis share overlapping symptoms but differ in predominant pathophysiological mechanisms, requiring tailored therapeutic strategies. • Predominantly central neuromodulators are most appropriate for epigastric pain syndrome, whereas predominantly peripheral neuromodulators are better suited for postprandial distress syndrome and gastroparesis-related nausea and vomiting. • A pragmatic, symptom-oriented, and mechanism-based approach may facilitate individualized treatment selection and optimize clinical outcomes.

🆕🔥Central & peripheral #Neuromodulators in #FD & #Gastroparesis: Symptom-Based #ClinicalReview‼️
🎯A pragmatic, symptom-oriented & mechanism-based approach facilitate individualized treatment selection & optimize clinical outcomes
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key points 1. POI is a common complication after abdominal sur-gery, prolonging the postoperative recovery time ofpatients. 2. POI will prolong the time for the intestines to empty,disrupt the intestinal flora balance, trigger related inflammatory responses, and cause disorder in the body's microenvironment. 3. Lactobacillus reuteri can alleviate intestinal metabolic disorders by promoting the expression of anti-inflammatory factors and inhibiting the expression of pro-inflammatory factors, thereby regulating the intestinal microbiota and facilitating the body's recovery.

🆕🔥 #Lactobacillus reuteri DSM 17938 improves #IntestinalMotility in 🐭 with #PostoperativeIleus by modulating #GutMicrobiota & #Macrophage‼️
🎯L. reuteri DSM 17938 is a promising probiotic for the prevention of #POI👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Summary • Guidelines recommend doubling the proton pump inhibitor (PPI) dosage for persistent nocturnal reflux symptoms, while wedge pillows are suggested as anon-pharmacological option. However, their efficacy compared with twice-daily PPI remains unstudied. • A wedge pillow combined with a morning PPI was non-inferior to twice-daily PPI in alleviating nocturnal reflux symptoms and was associated with greater improvements in sleep quality, despite no significant changes in reflux parameters, suggesting that the observed benefit may be mediated by sleep-related factors. • A wedge pillow can complement PPI therapy for man-aging nocturnal reflux symptoms, offering relief from night time symptoms and improving sleep quality inpatients not responding to morning PPI therapy.

🆕🔥#WedgePillow vs. evening #ProtonPumpInhibitor for #NocturnalReflux symptoms‼️
🎯Adding a wedge pillow was not inferior to evening PPI for nocturnal reflux symptoms ⏩Greater improvements in #sleep quality👏
👉https://onlinelibrary.wiley.com/doi/10.1111/nmo.70256
#ANMS #ESNM #GERD #PPI

Key Points: Twenty percent of patients with systemic sclerosis met diagnostic criteria for irritable bowel syndrome or functional dyspepsia, the two most common disorders of gut–brain interaction. The presence of symptoms consistent with disorders of gut–brain interaction is associated with more severe systemic sclerosis gastrointestinal disease and poorer quality of life. Effective management strategies have been used to treat disorders of gut brain interaction that could be tested in those patients with systemic sclerosis and co-morbid disorders of gut brain interaction to reduce symptom burden and improve quality of life.

🆕🔥Quantifying the Prevalence of #DisordersofGutBrainInteraction in #SystemicSclerosis‼️
👉 onlinelibrary.wiley.com/doi/10.1111/...
🎯20% of patients with systemic sclerosis met diagnostic criteria for #IrritableBowelSyndrome or #FunctionalDyspepsia👏
#ANMS #ESNM

Keypoints: Muscularis macrophages express high levels of ApoE after intestinal manipulation, but macrophage-specific deletion of ApoE does not impair gut motility or tissue morphology. While global ApoE deficiency mildly affects intestinal transit and promotes inflammation, macrophage-derived ApoE is dispensable for maintaining normal and postoperative gut motility.

🆕🔥#MuscularisMacrophage-derived #ApoE is dispensable for maintaining #GutMotility 🐭‼️
🎯Global ApoE deficiency delays gut transit & promotes inflammation, while macrophage-specific ApoE deletion does not impair motility #POI👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key Points: Calculating the CARS endoscopic score and performing FLIP panometry during endoscopy can assess the likelihood of an esophageal motility disorder and potentially expedite its diagnosis. A CARS score > 4 combined with FLIP-REO is highly predictive (100% specificity/100% positive predictive value) of an EGJ obstruction diagnosis (achalasia or confirmed EGJOO) on HRM.

🆕🔥Combined utility of #CARS endoscopic score & #FLIP based on real‐time assessments‼️
🎯Combination of CARS score ≥ 4 & reduced #EGJ opening on FLIP is highly predictive of an EGJ obstruction diagnosis #Achalasia #EGJOO👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key Points: Validated options for assessing gastric emptying in patients with dietary restrictions that preclude eating the standard egg meal. We developed and tested a vegan and allergy friendly meal using a vegan egg product for gastric emptying scintigraphy in 10 healthy volunteers after confirming in vitro stability/performance. The tested vegan egg meal appears to be a suitable alternative to the standard egg meal for patients who are not able to eat eggs, though additional studies with larger sample sizes are needed for further validation.

🆕🔥Pilot validation study of🌱plant‐based & allergy‐friendly alternative for testing #GastricEmptying #HealthyParticipants‼️
🎯Tested #vegan egg meal appears to be a suitable alternative to standard egg meal for patients who are not able to eat eggs
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key Points: This study reports the first documented case of myofilament loss in gastrointestinal smooth muscle cells in MELAS-associated chronic intestinal pseudo-obstruction (CIPO). Electron microscopic analysis demonstrated marked reduction of myofilaments accompanied by abundant abnormal mitochondria throughout the digestive tract, revealing that mitochondrial dysfunction may directly impair the smooth muscle contractile apparatus independent of previously described enteric nervous system abnormalities. These findings suggest that apparent superior mesenteric artery syndrome in MELAS patients may represent underlying CIPO with inherent intestinal structural vulnerability, supporting early implementation of enteral nutrition strategies that bypass affected gastrointestinal segments. Future research should focus on quantitative assessment of contractile protein abnormalities and development of therapeutic interventions targeting smooth muscle function in mitochondrial disorders.

🆕🔥Loss of #Myofilaments in gastrointestinal smooth muscle represents a novel pathological mechanism in MELAS-associated chronic intestinal Pseudo-obstruction #CIPO‼️
🎯 #Mitochondrial dysfunction directly impairs smooth muscle contractile apparatus
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key Points Patients with rectal prolapse only at defecation present a distinct, younger phenotype with more severe obstructive defecation symptoms, higher intrarectal push pressures, and better-preserved anal sphincter function. In contrast patients with spontaneous rectal prolapse are older and have higher fecal incontinence severity associated with lower resting anal tone and less sustained squeeze pressures. MRI defecography shows greater pelvic floor laxity in spontaneous prolapse (larger levator hiatus length/width, bowl volume, and wider resting anorectal angle), whereas defecation-only prolapse demonstrates more preserved hiatus anatomy and less patulous anal canal. Defecation-only prolapse may represent an early stage of disease. Identifying the phenotype of rectal prolapse can inform timing and type of intervention though surgical recurrence rates were similar between groups.

🆕🔥Distinct Phenotypes of #RectalProlapse #RP in Women‼️
🎯#Defecation-only RP represents an early stage of disease #preserved #AnalSphincter function ⬇️#PelvicFloorLaxity👏
🎯Patients with #Spontaneous RP are older & have⬆️ fecal incontinence severity
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Key Points • We employed Atmo Capsules to measure the frequency and amplitude of stomach contractions using a method called accelerometry which detects changes in capsule orientation and acceleration. • Stomach contractions occurring at a frequency of 3 cycles per minute were found which were lower in amplitude in patients with delayed gastric emptying compared to healthy controls and individuals with normal gastric emptying. • This technical assessment provides support for the Atmo Capsule accelerometer to characterize normal and abnormal stomach contractile profiles in patients with suspected motility disorders.

🆕🔥Accelerometric assessment of #Gastric Contractility using #Atmo Wireless Motility Capsule‼️
🎯Atmo Capsule enables precise quantification of gastric contraction profiles, permitting differentiation of normal from pathological motor patterns👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#NGM #ANMS #ESNM

KEY POINTS • Enterochromaffin (EC) cells release signaling molecules which can activate nearby sensory nerves.Whether this occurs via a conventional synapse for-mation is unknown. • EC cells rarely make contact with sensory nerves inthe upper gut but this frequency increases in the distal colon. • Neurite-like protrusiton on EC cells, named by some as “neuropods” are not a preferential site of contact with nerve fibres.

🆕 #Neuroepithelial landscape of #Enterochromaffin cells varies across #GI location‼️
✅EC cells rarely make contact with sensory nerves in upper gut but this frequency increases in distal colon👏
🎯 #Neuropods are not a preferential site of contact🔥
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

🚨Thrilled to welcome the new #EditorialTeam at
#NGM led by our new Editor-in-Chief, Prof. Daniel Keszthelyi 🎉
🔊We look forward to great science & fascinating breakthroughs ahead in #Neurogastroenterology & #Motility #GutBrainScience #ANMS #ESNM

CM Nitish Kumar distributes appointment letters to 7,468 ANMs Patna, July 7 (SocialNews.XYZ) With the Assembly elections due in Bihar this year, the state government has intensified efforts to provide employment opportunities, focusing on appointments in various departments. On Monday, Chief Minister Nitish Kumar handed over appointment letters to 7,468 newly appointed Auxiliary Nurse Midwives (ANMs) during a programme held at Samvad Hall, located at the Chief Minister’s Secretariat in Patna.

CM Nitish Kumar distributes appointment letters to 7,468 ANMs #CMNitishKumar #ANMs #socialnewsxyz

Youth with functional abdominal pain disorders have worse sleep than healthy youth and sleep disturbances are associated with abdominal pain. This highlights the need for investigation of mechanisms by which sleep disturbances affect abdominal pain and vice versa.

🆕🔥Youth with #FunctionalAbdominalPainDisorders have more #Sleep disturbances. A school-based study‼️
🎯 #Youth with functional abdominal pain disorders have worse sleep ▶️Sleep disturbances are associated with #abdominal #pain👏
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Summary The research employs resting-state functional mag- netic resonance imaging (fMRI) to assess brain function in Irritable Bowel Syndrome (IBS) patients noninvasively. A unique pattern of FCS alterations in brain areas govern pain regulation and emotional processing in IBS patients The identified abnormal FCS features have the potential to serve as effective biomarkers for IBS classification.

🆕🔥Classification of #IBS using Brain #FunctionalConnectivityStrength & #MachineLearning‼️ #NGMJournal
🎯A unique pattern of #FCS alterations in brain areas governs #Pain regulation & #Emotional processing in IBS patients
👉 onlinelibrary.wiley.com/doi/10.1111/...
#GutBrain🧠Axis #fMRI
#ANMS #ESNM

Summary Intestinal ischemia and reperfusion causes intestinal damage as a whole. Here, we demonstrate that this condition also affects enteric neurons that control intestinal motility. The pannexin-1 channel is a membrane protein important in cellular communication and also in controlling ATP levels. In this work, we treated animals subjected to ischemia and reperfusion with probenecid, a pannexin-1 inhibitor. PB was able to attenuate the harmful effects of I/R, recovering the number of enteric neurons and improving intestinal motility.

🆕🔥 #NGMJournal
✳️Changes in the #Pannexin Channel in Ileum Myenteric Plexus & Intestinal Motility Following Ischemia & Reperfusion‼️
🎯Pannexin channel blockage by probenecid is effective in attenuating the effects of I/R damage👏
👉 onlinelibrary.wiley.com/doi/full/10....
#ANMS #ESNM

Our global epidemiological study showed sex differences in individual disorders of gut–brain interaction(DGBI) symptoms, where women experienced higher prevalence in the vast majority of symptoms. This may indicate sex-specific abnormal regulation in women that increases symptoms compared to men. We found that both premenopausal women and comparably aged younger men tended to have greater symptom burden compared to their older counter-parts, which supports that there is an age effect on DGBI symptoms that is possibly independent of sex. Some indicators of visceral perception were increased in premenopausal women compared to postmenopausal women, and others of outlet dysfunction were increased in postmenopausal compared to premenopausal women, both of which differences were not shared by men. This, together with our finding that menses-related symptoms tend to be most bothersome and most co-morbid in pain-predominant DGBI (irritable bowel syndrome and functional dyspepsia), suggests that sex hormone-mediated effects on visceral perception and GI function may contribute to a greater symptom burden in women than men with DGBI.

🆕🔥Global epidemiology study shows symptom differences within 5 most common #DGBIs based on #sex #menopause #age & #menses‼️ #NGMJournal
🎯Sex hormone-mediated effects may contribute to ⏫symptom burden in women than men with #DGBI👏
👉 onlinelibrary.wiley.com/doi/epdf/10....
#ANMS #ESNM