New data on #mitochondria Aminoacyl-#tRNASynthetase, DARS2, reports secretion by #airway #epithelial cells in response to #TNFα, and a role in #paracrine signaling resulting in M1 #macrophage like phenotype in recipient THP1 cells.
doi.org/10.14814/phy...

Exogenous Vitamins K Exert Anti-Inflammatory Effects Dissociated from Their Role as Substrates for Synthesis of Endogenous MK-4 in Murine Macrophages Cell Line Vitamins K exert a range of activities that extend far beyond coagulation and include anti-inflammatory effects, but the mechanisms involved in anti-inflammatory action remain unclear. In the present ...

Exogenous Vitamins K Exert Anti-Inflammatory Effects Dissociated from Their Role as Substrates for Synthesis of Endogenous MK-4 in Murine Macrophages Cell Line #vitaminK #IL6 #TNFα #PGD2 #COX2 #MMP9 #MECFS #LongCovid

www.mdpi.com/2073-4409/10...

Inactivated SARS-CoV-2 induces acute skeletal muscle damage in human K18-hACE2 transgenic mice The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in over 7 million global fatalities and billions of individu…

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"Significant elevations were noted in inflammatory mediators in the muscle of inactivated #SARSCoV2 mice, including high mobility group box-1, tumor necrosis factor-alpha, phospho-nuclear factor kappa B, caspase 11, and pannexin-1." #HMGB1 #TNFα #NFκB #PANX1

Potential role of tirzepatide towards Covid-19 infection in diabetic patients: a perspective approach In Covid-19, variations in fasting blood glucose are considered a distinct risk element for a bad prognosis and outcome in Covid-19 patients. Tirazepatide (TZT), a dual glucagon-like peptide-1 (GLP-1)...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Besides, #GIP1 inhibits expression of #IL1β, #IL6, #MCP1, chemokines and #TNFα."

"Therefore, using GIP-1RA like TZT may inhibit the onset of inflammatory disorders in severely affected #Covid19 patients."

Therapeutic effect of ginger on gastritis: Regulation of STAT3/MAPK signaling pathway and gastrointestinal hormone balance Gastritis is a disease caused by multifactorial etiology. Ginger a widely used natural spice, possesses various beneficial properties, including antio…

www.sciencedirect.com/science/arti...

"This activation subsequently leads to the production of pro-inflammatory cytokines such as interleukin-8 ( #IL8), tumor necrosis factor α ( #TNFα), #IL1β, and #IL17, further exacerbating inflammation."