⏰ New preprint from @lizihegarty.bsky.social, @erinwatson.bsky.social, @bainlab.bsky.social & @doctoremmerson.bsky.social shows that 1hr in PFA-based fixative allows detection of #macrophage subsets in the #salivarygland, #pancreas & #kidney while preserving #epithelial & #endothelial architecture

This week: A team at Westlake University identified a neuro-#epithelial axis in the skin that can tune regional immunosurveillance against #melanoma.

Article: https://bit.ly/4arswnF
Episode: https://bit.ly/4kEDz1s

a dictionary of #epithelial responses to 79 secreted niche factors at single cell resolution

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🩸 samples are directly related to 💩 ➡️ carriage is the main risk factor for BSI development

🔹 Adhesion and TEER analyses of 22 isolates suggest that #Klebsiella is unlikely to cross the #epithelial barrier

Omega-7 Secrets: Why Sea Buckthorn Isn't Just Vitamin C In today's episode we're exploring Hippophae rhamnoides, or sea buckthorn, a resilient shrub packed with over 190 bioactive nutrients. We explain why focusing on its Vitamin C content misses the true therapeutic potential: Omega-7 (palmitoleic acid), the rarest fat that sends repair signals to epithelial cells and mucous membranes. Learn the critical distinction: fruit oil (rich in Omega-7) is best for skin repair and dryness (like dry eyes), while seed oil (high in Omega-3/6) supports cardiovascular health and manages cholesterol. Finally, we detail how to avoid low-quality products by seeking products made only via Supercritical CO2 extraction. Reference: https://foodnourish.net/hippophae-health-benefits/

📣 New Podcast! "Omega-7 Secrets: Why Sea Buckthorn Isn't Just Vitamin C" on @Spreaker #antioxidant #cholesterol #dryeyes #epithelial #extraction #fruitoil #heart #himalayas #hippophae #inflammation #membranes #mucous #omega7 #palmitoleic #repair #seabuckthorn #seedoil #superfood #vaginal

#scRNAseq identifies #prolactin signaling as a key driver of #adenomyosis, revealing PRLR overactivation in #epithelial and #fibroblast subclusters, and shows that PRLR blockade with HMI-115 markedly alleviates disease. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

🔥Hot Off the Press | #Nature: MAPK-induced epithelial plasticity is associated with #CRC therapeutic resistance
🔸Approaches designed to control stem cell fate and #epithelial plasticity, or target #tumors with limited heterogeneity could improve therapeutic effectiveness.
#MAPK

Epithelial Barrier Diseases Among Adult Patients With Seborrheic Dermatitis This cohort study examines the frequency of epithelial barrier diseases among adult patients with seborrheic dermatitis.

Teoría de la barrera epitelial es fundamental en la patogénesis de la dermatitis seborreica y otras enfermedades de la barrea epitelial #epithelial #dermatitis jamanetwork.com/journals/jam...

New data on #mitochondria Aminoacyl-#tRNASynthetase, DARS2, reports secretion by #airway #epithelial cells in response to #TNFα, and a role in #paracrine signaling resulting in M1 #macrophage like phenotype in recipient THP1 cells.
doi.org/10.14814/phy...

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!

Resolution of epithelial dysfunction in eosinophilic esophagitis is mediated by an HIF-1α-CD73-adenosine signaling axis Inflammatory hypoxia is induced by eosinophilic inflammation, while a decreased expression in the key hypoxic regulator, hypoxia-inducible transcripti…

Huge congratulations to rock 💫 Shauna Kellett from my lab publishing her @ResearchIreland funded MSc(Res) 🎉

showing that #HIF-1α-CD73-adenosine signaling axis is important in the resolution of #EoE associated #epithelial dysfunction

www.sciencedirect.com/science/arti...

Single-cell atlas of cervical organoids uncovers epithelial immune heterogeneity and intercellular cross-talk during Chlamydia infection Organoids and single-cell analysis uncover diverse cervical epithelial immune strategies to fight infection.

New research led by a team at @au.dk has found that cervical #epithelial cells play an active role in fighting infections. They used #organoids and single-cell mapping to show how these cells in the cervix detect and respond to infection.

www.science.org/doi/10.1126/...

The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity - Genes & Immunity Genes & Immunity - The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity

The #epigenomic #landscape of #bronchial #epithelial cells reveals the establishment of #trained #immunity

#Genes & #Immunity @springernature.com
www.nature.com/articles/s41...

Epithelial Cells Use Electricity to Expel Weak Neighbors

Researchers found that epithelial cells use the ENaC sodium channel to sense low‑energy cells, leading to extrusion; about 70% of expelled cells show a brief ion‑driven shrinkage phase. Read more: getnews.me/epithelial-cells-use-ele... #epithelial #ionchannels

How epithelial junctions mature: Study shows conformational transition in key protein Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...

Exciting new paper by the group of Carsten Grashoff @sfb1348.bsky.social @uni-muenster.de
shows conformational change in alpha-Catenin during maturation of #epithelial junctions
www.uni-muenster.de/news/view.ph...

This study shows that RAB26 promotes #ProstateCancer (PCa) cell growth while inhibiting #apoptosis, regulating #Epithelial - #mesenchymal transition and stemness, and offering potential targets for targeted therapy in PCa. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Interested in doing exciting research on #epithelial #plasticity in the #kidney or #intestine?

Then please check out our recent job ads for #PhD and #Postdoc positions!

www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...
www.nature.com/naturecareer...

PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes Summary: This study investigates the PIWI-piRNA pathway in colon cancer using a nuanced bioinformatic and cell-based approach, linking the downregulation of PIWIL2 to disease progression, transposable...

Excited to share our most recent publication, where we delve into the roles of the #PIWI - #piRNA pathway in #transposon regulation, in #epithelial #homeostasis and #cancer. Fabulous work by the recently graduated student in the lab @sciencealyssa.bsky.social journals.biologists.com/bio/article/...

Sharing for multiresistant strains efforts in #metabolomics #epithelia #diet #guts #epithelial #toxins #vibrio #cholerae #cólera #microbiology #lactate #coffeaarabica #sewage #host #endemic #epidemic #MDR #antibiotic

Using engineered tissue to energise biohybrid robotics Understanding the behaviour of epithelial tissue could open the door to both improved health outcomes and next-generation biohybrid...

Can your #gut inspire soft #robots?🧬🤖

Xavier Trepat @ibecbarcelona.eu is uncovering how #epithelial tissue renews itself, opening doors to self-healing biohybrid robots.

👉 buff.ly/vubQzP6

#FrontierResearch #GeneEditing #Bioengineering #Microfluidics @xaviertrepat.bsky.social

The subcellular topology of the RNAi machinery is multifaceted and reveals adherens junctions as an epithelial hub - Scientific Reports Scientific Reports - The subcellular topology of the RNAi machinery is multifaceted and reveals adherens junctions as an epithelial hub

Very happy to share our latest work revealing that localization of the #RNAi machinery at #adherens junctions is a universal feature of #epithelial cells and tissues. Great work and team effort by Joyce Nair-Menon, the lab and collaborators! @sciencealyssa.bsky.social www.nature.com/articles/s41...

Cathepsin L plays a crucial role in the diversity and functionality of T cells An international team led by Ludger Klein has provided important insights into the maturation of T cells in the thymus, which is a central process in the development of a functioning immune system.

📣 New in @natimmunol.nature.com:
#Cathepsin L plays a crucial role in the diversity and functionality of #CD4 #Tcells

➡️ www.med.lmu.de/bmc/en/news/...

#cortical #epithelial #cells #receptor #thymus #immune #immunology #MHC #major #histocompatibility #complex #cysteine #protease

📷 J.Greune

A beautiful study out now in @cp-devcell.bsky.social showing that tissue architecture drives cell fate in branched #epithelial organs during #development.

Super happy to be part of this initiative! Together with @agvazquez.bsky.social we will be working on the interaction between #Alveolar #Macrophages and #Epithelial #Cells in the #lung
Still time left to apply!! www.linkedin.com/posts/elvira...
#immunosky

The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis - Nature Immunology Hegazy and colleagues demonstrate that epithelial oncostatin M receptor expression drives gut inflammation and tumor formation.

#EveryCellIsAnImmuneCell! Cineus, Hegazy &co show @natimmunol.nature.com that during #colitis ILCs produce IL22 which drives oncostatin M #OSM signaling in intestinal #epithelial cells recruiting immune cells, exacerbating inflammation & being essential for tumorigenesis & colorectal tumor growth!

The first entry from the #geneticArt exhibition @geneticsub.bsky.social to appear here is from Keerthi. She named it “Beauty in imperfection” and it depicts the #tracheal system of a #Drosophila embryo outlined in blue (CBP), stained with E-Cadherin (red), highlighting the #epithelial junctions

Check out new work @plosbiology.org from Daniel St Johnston´s lab visualizing how secretory cargo is targeted to apical vs. basolateral domains in #epithelial cells in real time. Nice collaboration highlighting the power of #RUSH in #Drosophila!

The @katajistolab.bsky.social modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming.

Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a

SciTech Chronicles. . . . . . . . .Mar 18th, 2025 Hope clouds observation. Vol II No 70 497 links Curated Tornadoes are shifting east of Tornado Alley. https://www.livescience.com/planet-e...

SciTech Chronicles. . . . . . . . .Mar 18th, 2025

bit.ly/stc031825

#pattern #eastward-shift #Mississippi #Tennessee #bioelectricity #epithelial # microelectrode #calcium #AI #age-related #Biobank #saliency #RNS #Wearable-LLM #PTSD #EEG #Observatory #hydrothermal #magma #steam

Great to host Chris Lucas from Edinburgh to give the @uofgsii.bsky.social Immunology seminar, on #macrophage #epithelial combined roles in #lung regeneration, key steps to new translational science in respiratory medicine. And learning across disciplines!