Ivan Zanoni

@lozanzi.bsky.social

13 hours ago

#WeekendRead! #EveryCellIsAnImmuneCell! Julius, Touhara &co show @nature.com that, during gut #elminth infections, tufts cells release acetylcholine in 2 waves to induce serotonine secretion by enterochromaffin cells, activating vagal nerve to suppress food intake! www.nature.com/articles/s41...

Ivan Zanoni

@lozanzi.bsky.social

6 days ago

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells While inflammaging supposedly drives some of the most common diseases affecting the elderly, little is known about the tissue drivers of inflammaging.…

#WeekendRead! #EverycellIsAnImmuneCell! Allen, @ucsfpenglab.bsky.social &co show @cp-immunity.bsky.social that in #inflammaging, lung #fibroblasts activate NFkB & recruit monocytes/IMs that produce IL15 expanding dysfunctional CD8 T cells that drive excessive neutrophils, inflammation & lung damage!

Ivan Zanoni

@lozanzi.bsky.social

3 weeks ago

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!

Ivan Zanoni

@lozanzi.bsky.social

4 weeks ago

Precancerous niche remodelling dictates nascent tumour persistence - Nature A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlyin...

#WeekendRead! #SmartTumor! #EveryCellIsAnImmuneCell! Amazing work @nature.com by @mariapalcolea.bsky.social Skrupskelyte, Rojo &co showing the stress response driven by nascent tumors induces a wound healing program in surrounding fibroblasts driving a #PreCancerousNiche that fosters tumorigenesis!

Ivan Zanoni

@lozanzi.bsky.social

1 month ago

Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity - Nature Immunology Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...

#WeekendRead! #EveryCellIsAnImmuneCell! Vollmers Turley &co show @natimmunol.nature.com that lack of CSF1 in skin #fibroblasts decreases macrophage numbers dampening wound repair, and in turn boosts fibroblasts! In human #scleroderma the cellular circuit between fibroblasts & macrophages is altered!

Ivan Zanoni

@lozanzi.bsky.social

1 month ago

Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection Neuroimmune interactions shape host responses to infection, but the molecular role of sensory neurons during viral infection remains unclear. Roger et al. show that HSV-1-activated sensory neurons pro...

#EveryCellIsAnImmuneCell! Ugolini, Roger &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 activates sensory #neurons that produce the neuropeptide SP to limit neutrophil influx, & TAFA4 that drives IL-10 by macrophages, overall fostering disease tolerance!

Ivan Zanoni

@lozanzi.bsky.social

3 months ago

HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded large EVs, known as melanosomes, that directly engage and impair CD8+ T cell receptors.

#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...

Ivan Zanoni

@lozanzi.bsky.social

3 months ago

Human gut M cells resemble dendritic cells and present gluten antigen - Nature An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune syst...

#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses!
doi.org/10.1038/s415...

Ivan Zanoni

@lozanzi.bsky.social

4 months ago

Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche - Nature Immunology Turley and colleagues find that Gremlin1-expressing lymph node fibroblastic reticular cells support dendritic cell homeostasis via provision of FLT3L.

#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!

Ivan Zanoni

@lozanzi.bsky.social

4 months ago

You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...

#InflammasomePower! #EveryCellIsAnImmuneCell! #MysterySolved!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!

Ivan Zanoni

@lozanzi.bsky.social

4 months ago

A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer Triple-negative breast cancer (TNBC) is characterized by high risks of relapse or metastatic disease. Mattavelli et al. identify a chemokine axis that recruits immunosuppressive monocytes to tumor-dra...

#WeekendRead! #EveryCellIsAnImmuneCell! Riedel, Mattavelli, Helal &co show @cp-immunity.bsky.social that fibroblasts in breast cancer metastatic lymph nodes sense tumor-derived TLR4 agonists to attract monocytes & form an immunosuppressive niche, favoring lung metastasis!
dlvr.it/TPCYjz

Ivan Zanoni

@lozanzi.bsky.social

4 months ago

Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance Cancer cells exploit distant tissues and organs to escape immune surveillance by activating nociceptive neurons, which remodel tumor-draining lymph nodes into an immune-suppressed state. Blocking this...

#WeekendRead! #EveryCellIsAnImmuneCell! #SmartTumors. Ji Zhang &co show @cp-cell.bsky.social that tumor cells undergo ER stress under immune pressure leading to activation of nociceptive neurons which signal in draining lymph node driving immune suppression via decreased CCL5 & favoring tumor growth

Ivan Zanoni

@lozanzi.bsky.social

5 months ago

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!

Ivan Zanoni

@lozanzi.bsky.social

5 months ago

#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...

Ivan Zanoni

@lozanzi.bsky.social

5 months ago

Maternal stress triggers early-life eczema through fetal mast cell programming - Nature Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to otherwise harmless mechanical friction after birth.

#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...

Ivan Zanoni

@lozanzi.bsky.social

7 months ago

CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation - Nature Immunology Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.

#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...

Ivan Zanoni

@lozanzi.bsky.social

8 months ago

A gut sense for a microbial pattern regulates feeding - Nature A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.

#WeekendRead! #EveryCellIsAnImmuneCell! #TollPower! Kaelberer Bohorquez &co show @nature.com that #TLR5 signaling in response to flagellin drives neuropeptide PYY release by gut colonic neuropod cells, activating vagal neurons that signal to #brain, reducing feeding via a “neurobiotic sense”!

Ivan Zanoni

@lozanzi.bsky.social

9 months ago

#WeekendRead! #EveryCellIsAnImmuneCell! Li Li Lin &co show @cp-immunity.bsky.social that vagal nerve stimulation protects against heart failure by decreasing, via NRF2 activation, monocyte-derived macrophages with TNF, hypertrophic, & profibrotic signatures!
www.cell.com/immunity/abs...

Ivan Zanoni

@lozanzi.bsky.social

9 months ago

#SharingIsCaring or not? @nature.com #MitochondriaPower #CancerMetastasis #EveryCellIsAnImmuneCell

Ivan Zanoni

@lozanzi.bsky.social

10 months ago

Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.

#WeAreWhatWeEat! #EveryCellIsAnImmuneCell! Dixit, Lee &co show @natmetabolism.nature.com that caloric restriction depletes cysteines, driving weight loss & browning of white adipose tissue via sympathetic nervous system-derived noradrenaline signaling, reversing metabolic inflammation in obese mice!

Ivan Zanoni

@lozanzi.bsky.social

10 months ago

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...

#WeekendRead! #EveryCellIsAnImmuneCell! @bryanyipp.bsky.social &co show @cp-immunity.bsky.social that nociceptor neurons decrease lung fibrosis by blocking VIP (vasoactive intestinal peptide) release by alveolar macrophages, preventing neutrophil recruitment & NETosis which contributes to fibrosis!

Ivan Zanoni

@lozanzi.bsky.social

10 months ago

The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis - Nature Immunology Hegazy and colleagues demonstrate that epithelial oncostatin M receptor expression drives gut inflammation and tumor formation.

#EveryCellIsAnImmuneCell! Cineus, Hegazy &co show @natimmunol.nature.com that during #colitis ILCs produce IL22 which drives oncostatin M #OSM signaling in intestinal #epithelial cells recruiting immune cells, exacerbating inflammation & being essential for tumorigenesis & colorectal tumor growth!

Ivan Zanoni

@lozanzi.bsky.social

11 months ago

Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.

#WeekendRead! #EveryCellIsAnImmuneCell! Xie, Rose, Hu, Jackson &co show @cp-cell.bsky.social that cholinergic enteric neurons sense gut mechanical forces via Piezo1 to regulate intestinal peristalsis during homeostasis, exercise, & colitis, also decreasing inflammation & damage during colitis!

Ivan Zanoni

@lozanzi.bsky.social

11 months ago

Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.

#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...

Ivan Zanoni

@lozanzi.bsky.social

11 months ago

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…

#EveryCellIsAnImmuneCell! @ikinglab.bsky.social @susanwestfall.bsky.social show @cp-cell.bsky.social that during elminth infections CD8 T cells sense #microbiota via MYD88 (not TCR) producing #interferon-g which signals on stromal cells recruiting neutrophils & on muscle cells avoiding dysmotility!

Ivan Zanoni

@lozanzi.bsky.social

11 months ago

Red blood cells undergo lytic programmed cell death involving NLRP3 Complement exposure induces programmed cell death of red blood cells due to the intracellular activation of miniNLRP3 and caspase-8. Inhibiting NLRP3 signaling reduces cytoskeletal damage and prevents...

#EveryCellIsAnImmuneCell!! #MiniNLRP3: welcome to #Spectosis! Liu, Hu &co show @cell-cellpress.bsky.social that #complement activation drives red blood cell #RBC death by activating a miniNLRP3-ASC-caspase8 complex, causing proteolysis of b-spectrin & sustaining autoimmune hemolytic anemia!

Ivan Zanoni

@lozanzi.bsky.social

1 year ago

Periarteriolar niches become inflamed in aging bone marrow, remodeling the stromal microenvironment and depleting lymphoid progenitors | PNAS In early postnatal and young adult bone marrow, Leptin receptor–expressing (LepR+) stromal cells and endothelial cells synthesize factors required ...

#WeekendRead! #LiveForever! #EveryCellIsAnImmuneCell! #InterferonsFriendsOrFoes?! Morrison &co show @pnas.org that with #aging, bone marrow arteriolar endothelial & T cells produce type I & II IFNs which can be targeted to prevent lymphoid progenitor depletion! www.pnas.org/doi/10.1073/...

Ivan Zanoni

@lozanzi.bsky.social

1 year ago

GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.

#WeekendRead! #EveryCellIsAnImmuneCell! Mills @fungalspore.bsky.social &co show @ Science Immunology that during lung fungal infections, lung epithelial cells independently respond to IL-1 & type III #interferons by producing GM-CSF which potentiates fungal killing by neutrophils!

Ivan Zanoni

@lozanzi.bsky.social

1 year ago

Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disr...

#EveryCellIsAnImmuneCell! June Round &friends show @science.org that in early life bacteria & fungi cooperate to expand insulin producing β islets via macrophage infiltration & that recognition of commensal yeast cell wall can protects against diabetes in adults! www.science.org/doi/10.1126/...

Ivan Zanoni

@lozanzi.bsky.social

1 year ago

Immunomodulatory role of the stem cell circadian clock in muscle repair The stem cell circadian clock orchestrates metabolic and immune signaling to time muscle regeneration following injury.

#WeekendRead! #EveryCellIsAnImmuneCell! Peel Zhu &co show @ Science Advances that after muscle injury, the circadian clock & hypoxia sustain glycolysis in muscle stem cells to drive CCL2 & neutrophil recruitment, facilitating muscle repair! www.science.org/doi/10.1126/...