Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...

#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!

Periarteriolar niches become inflamed in aging bone marrow, remodeling the stromal microenvironment and depleting lymphoid progenitors | PNAS In early postnatal and young adult bone marrow, Leptin receptor–expressing (LepR+) stromal cells and endothelial cells synthesize factors required ...

#WeekendRead! #LiveForever! #EveryCellIsAnImmuneCell! #InterferonsFriendsOrFoes?! Morrison &co show @pnas.org that with #aging, bone marrow arteriolar endothelial & T cells produce type I & II IFNs which can be targeted to prevent lymphoid progenitor depletion! www.pnas.org/doi/10.1073/...

PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease | Journal of Experimental Medicine | Rockefeller University Press Many PARPs are IFN-stimulated genes, of which PARP7 potently inhibits IFN signaling. Jeltema et al. show that Parp7 deficiency in mice leads to systemic au

#InterferonsFriendsOrFoes?! Jeltema, Yan &co show @jem.org that several members of the PARP family are IFN-stimulated genes that negatively regulate type I IFNs, & that PARP7 does so by binding & blocking IRF3! PARP7 loss leads to autoimmunity & lung disease. #ScienceSavesLives buff.ly/4b3aV5j

Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.

#WeekendRead! #ZombieNeutrophils! #InterferonsFriendsOrFoes?! Stallings &co show @ Cell Host & Microbe that micobacterium drives the releases of NET from live neutrophils (that lose their 🧠!) thanks to PAD4 & type I #interferons, favoring #Myb growth! www.cell.com/cell-host-mi...