NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells While inflammaging supposedly drives some of the most common diseases affecting the elderly, little is known about the tissue drivers of inflammaging.…

#WeekendRead! #EverycellIsAnImmuneCell! Allen, @ucsfpenglab.bsky.social &co show @cp-immunity.bsky.social that in #inflammaging, lung #fibroblasts activate NFkB & recruit monocytes/IMs that produce IL15 expanding dysfunctional CD8 T cells that drive excessive neutrophils, inflammation & lung damage!

The backdrop of a dawn sky with orange and pink clouds displays historical fiction novel Dawn of the Franks - the story of Basina of Thuringia. The cover features a backdrop of trees silhouetted against an orange sky and the rising sun. In the foreground a blonde man kneels before a medieval couple. A dark-haired man in a red tunic has his arm around a woman with a white mantle and a fur cloak. The text reads 'The might of Rome has waned. And the sun is rising on the Dark Ages'. https://mybook.to/DawnoftheFranks

Bitter betrayal. forbidden romance, and a love story to transform history...

#HistoricalFiction Dawn of the Franks - the story of Basina of Thuringia
mybook.to/DawnoftheFra...
#eBook #paperback #KindleUnlimited #weekendread 📚⚔️

Robots in the Garden A different way to think about your PKM system — and roles AI can play in it.

Really great ideas here from Jorge Arango on using AI chat tools for research, learning, and deep thinking.

Perfect long read for the weekend.

#weekendread

jarango.com/2026/03/27/r...

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

#WeekendRead! #RemeberMe! @snaga13.bsky.social @jbuenrostro.bsky.social &co show @nature.com that intestinal stem cells remember multiple cycle of inflammation by epigenetically favoring AP-1 accessibility, thus increasing proliferation & repair, but also favoring tumorigenesis!

In the background, a pale sun peers over the top of a hill through a hazy red sky. Below it the trees are leafless and there is snow on the ground. Over it is historical fiction novel Tyrant Whelp with the cover featuring the hooded face of a man and a sword protruding from a stone. The text reads In Britannia King Arthur presides over a golden age... But as the sun shines without brightness, the realm is plunged into a wasteland of ice, famine and a war where many of its finest must fall. Yet for Custennin of Dumnonia, greatness beckons. Is he up to the task? Tyrant Whelp https://mybook.to/TyrantWhelp

A kingdom in ruins. A throne up for grabs. And the man who inherits it? Not a hero.
Power corrupts. Loyalty shatters. Who will survive Camelot’s fall?
#Arthurian #HistoricalFiction Tyrant Whelp is only #99cents or #99p
mybook.to/TyrantWhelp
#WeekendRead #KindleCountdownDeal #Bargain 📚⚔️

A purple background displays historical fiction novel God's Maidservant - the story of Adelaide of Italy. The cover features a blonde woman in a red and black medieval dress in front of a stone abbey. The text says 'Throughout an unhappy marriage and a tormented widowhood, only faith sustains the Italian queen. Will King Otto of Germany be the answer to Adelheid's prayers? https://mybook.to/GodsMaidservant

“You will be my wife one day, Adelheid. Why not agree to it willingly?”
God's Maidservant - the story of Adelaide of Italy
mybook.to/GodsMaidserv...
#HistoricalFiction #WeekendRead #eBook #paperback #KindleUnlimited ⚔️📚

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages Wu et al. reveal an inverse relationship between psoriasis severity and postprandial APOB48 levels in humans. Using a newly developed photoconvertible APOB knockin mouse and intestinal organoids, they...

#WeekendRead! #SkinGutAxis! Wu &co show @cp-cellmetabolism.bsky.social that #psoriasis induces a population of #intestinal macrophages that produce #IL1b & alters lipid absorption, increasing epithelial lipid accumulation, thus fostering gut inflammation!

A valley of rocks and trees in autumnal colours displays historical fiction novel The Saxon Marriage. The cover features a woman in a red and turquoise medieval dress embracing a man in armour. The text reads: Enemies muster on the border, but the deadliest of foes lurk much closer to home... https://mybook.to/SaxonMarriage

A troubled Wessex princess.
The young hope of Saxony.
An ancient bloodline.
An upstart dynasty.
Will The Saxon Marriage be a happy one?

Only #99cents or #99p for one week only! mybook.to/SaxonMarriage
#HistoricalFiction #KindleCountdownDeal #WeekendRead #BargainBook 📚👸

The impossible task of caring for ageing parents who did not care for you: ‘There’s a lot of reliving old triggers’ It’s hard under the best of circumstances. For those with difficult family relationships or estrangement, it’s even more complicated

#WeekendRead

Ageing
The impossible task of caring for ageing parents who did not care for you: ‘There’s a lot of reliving old triggers’
It’s hard under the best of circumstances. For those with difficult family relationships or estrangement, it’s even more complicated

Five Fatal Flaws for Friday?
#WeekendRead

Wow! For a limited time both THE ART OF THE DECOY and A WEATH OF DECEPTION audiobooks are 1.99 . Only on Chirp . If you enjoy #audiobooks you'll never get then at a better deal. #audiobookdeal #bookdeal #WeekendRead #awardwinning #bookseries #mysterynovel #antiquedealer #Vermont

Alright, part 2 of my #ebook "My Coworker Teddy" is out now on #kindle. You can read all 12,000 words of this series (so far) on #KindleUnlimited
#LGBTQ+ #Gay #Erotic #Romance #coworkerstolovers #smut #weekendread #eroticromance #gayromance

LINK HERE:
www.amazon.ca/gp/product/B...

MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC gl…

#WeekendRead #MysterySolved! MYC is one of the most famous #oncogenes & a potential therapeutic target but how does it work? Uhl, Eilers &co show @cp-cell.bsky.social that MYC binds introns during RNA stalling preventing export of dsRNA & DNA/RNA hybrids & anti-tumoral TLR3 activation!

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!

State Property Tax Reform Efforts Continue Amid Local Fiscal Strains In the years following the COVID-19 pandemic, lawmakers have repeatedly pursued measures to cut property taxes—or even eliminate them. But such initiatives often bring new fiscal pressures. They can c...

Important #WeekendRead: The Pew Charitable Trusts recently wrote about the consequences of property tax cuts on local government services. Check it out: www.pew.org/en/research-...

In the background, a pale sun peers over the top of a hill through a hazy red sky. Below it the trees are leafless and there is snow on the ground. Over it is historical fiction novel Tyrant Whelp with the cover featuring the hooded face of a man and a sword protruding from a stone. The text reads In Britannia King Arthur presides over a golden age... But as the sun shines without brightness, the realm is plunged into a wasteland of ice, famine and a war where many of its finest must fall. Yet for Custennin of Dumnonia, greatness beckons. Is he up to the task? Tyrant Whelp https://mybook.to/TyrantWhelp

A kingdom in ruins. A throne up for grabs. And the man who inherits it? Not a hero.
Power corrupts. Loyalty shatters. Who will survive Camelot’s fall?

#Arthurian #HistoricalFiction Tyrant Whelp mybook.to/TyrantWhelp
#eBook #paperback #KindleUnlimited #WeekendRead

Commensal enteric virome regulates intestinal carbohydrate digestion and absorption The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various…

#WeekendRead! #ViromePower! Lin, Li &co show @cp-cellhostmicrobe.bsky.social that the virome regulates sugar digestion & absorption by intestinal epithelial cells #IECs by favoring production of IL-22 via an antigen presenting cell-#Th17 axis!

Precancerous niche remodelling dictates nascent tumour persistence - Nature A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlyin...

#WeekendRead! #SmartTumor! #EveryCellIsAnImmuneCell! Amazing work @nature.com by @mariapalcolea.bsky.social Skrupskelyte, Rojo &co showing the stress response driven by nascent tumors induces a wound healing program in surrounding fibroblasts driving a #PreCancerousNiche that fosters tumorigenesis!

The backdrop of a dawn sky with orange and pink clouds displays historical fiction novel Dawn of the Franks - the story of Basina of Thuringia. The cover features a backdrop of trees silhouetted against an orange sky and the rising sun. In the foreground a blonde man kneels before a medieval couple. A dark-haired man in a red tunic has his arm around a woman with a white mantle and a fur cloak. The text reads 'The might of Rome has waned. And the sun is rising on the Dark Ages'. https://mybook.to/DawnoftheFranks

Bitter betrayal, forbidden romance, and a love story to change the course of history...

#HistoricalFiction Dawn of the Franks - the story of Basina of Thuringia
mybook.to/DawnoftheFra...
#eBook #paperback #KindleUnlimited #WeekendRead #WomensHistoryMonth

HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier Trillions of adhesion-capable bacteria reside in the gut, yet they rarely attach to healthy host tissue. Here, Overstreet et al. reveal that HMGB1 in colonic mucus directly targets bacterial adhesins ...

#WeekendRead! #MisterySolved! Overstreet Messer &co show @cp-cellhostmicrobe.bsky.social that HMGB1 in the gut mucus broadly targets a bacterial virulence factor preventing bacterial mucus invasion & tissue adhesion! #IBD is associated with low HMGB1!

Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity - Nature Immunology Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...

#WeekendRead! #EveryCellIsAnImmuneCell! Vollmers Turley &co show @natimmunol.nature.com that lack of CSF1 in skin #fibroblasts decreases macrophage numbers dampening wound repair, and in turn boosts fibroblasts! In human #scleroderma the cellular circuit between fibroblasts & macrophages is altered!

Andrew Mountbatten-Windsor and the strange British phenomenon of the snatched backseat picture Andrew Mountbatten-Windsor is the latest in a long line of famous people photographed in the back of a car.

#WeekendRead

It requires skill, technique, patience - and a little bit of luck.
We've been speaking to snappers about the art of the "one shot" - and also asking showbiz experts why we're all so fascinated by the snatched backseat photo.

www.bbc.com/news/article...

Hanoi's most popular street could kill you Train Street started life as a razor-thin alley with a train rushing through it. Now, it's swarmed with Instagrammable cafes and tourists who can't stay away, despite the risks.

#WeekendRead

Train Street started life as a razor-thin alley with a train rushing through it. Now, it's swarmed with Instagrammable cafes and tourists who can't stay away, despite the risks.

www.bbc.com/travel/artic...

From a terrifying Viking spectre to a fearsome beast stalking Dartmoor's tin miners - enter a world that is Mysteriously Medieval...
mybook.to/Mysteriously...
#eBook #paperback #KindleUnlimited #WeekendRead

A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression An in vivo, noncanonical ferroptosis pathway, critical for tumor supression, is driven by reactive oxygen species-induced phosphatidic acid peroxidation at the ER under the control of the GPX1-OSBPL8 ...

#WeekendRead! #NoTimeToDie! Gu, Kagan, Xia &co show @cp-cell.bsky.social that ROS drive lipid peroxidation at the ER causing membrane rapture & ferroptotic death which is blocked by GPX1 recruitment via OSBPL8 to the ER & oxidized lipid reduction! Knockdown of GPX1/OSBPL8 blocks tumor growth!

#WeekendRead! #InterferonFriendOrFoe? @jeffdowney11.bsky.social @filswirski.bsky.social &co show @cp-immunity.bsky.social that upon severe flu lung infection, IAV is transported to the heart by DCs, where it infects cardiomyocytes to drive IFN-I, causing cardiac dysfunction! doi.org/10.1016/j.im...

A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensin…

#WeekendRead! #InterferonPower! Dunphy @sancholab.bsky.social &co show @cp-immunity.bsky.social that in #macrophages, STING leads to type I #IFNs & ISG15-dependent ISGlatyion of mitochondrial proteins, increasing efferocytosis & driving epigenetic remodeling thus supporting inflammation resolution!

Why not surprise someone you love with a #Romance #eBook on #ValentinesDay!
Like this #Spooky #HistoricalRomance Call of the Viking Dead
mybook.to/vikingdead
#WeekendRead 📚⚔️👻❤️

#OnThisDay in 858, Scottish king, Kenneth Mac Alpin died.
Follow his rise to power through the eyes of the forgotten woman at his side...

Kenneth's Queen mybook.to/KennethsQueen
#eBook #paperback #KindleUnlimited #WeekendRead #OTD #ValentinesDay 📚⚔️❤️

When you were reading about Botticelli, and the sun decided to add a rainbow to the page. #smalltouchingmoments #weekendread #Botticelli