A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!

From the January issue: Chromatin accessibility profiling of #keratinocytes from clinically healed psoriatic skin reveals #epigenetic alterations https://ow.ly/x7HI50XplAq #medderm #psoriasis #dermsky

From the January issue: #Keratinocytes as key players, not bystanders, in #psoriasis: loss of function of an epithelial-specific transcription factor may drive disease https://ow.ly/O4FO50XaySr #medderm #dermsky

#Keratin 15 promotes a progenitor cell state in basal #keratinocytes of skin #epidermis. say Catherine J. Redmond, Pierre A. Coulombe and colleagues @umich.edu: rupress.org/jcb/article/...

#Cytoskeleton #StemCells

Richards, Devenport et al. @princetonmolbio.bsky.social show that #melanocyte precursors form dynamic E-cadherin based attachments to surrounding #keratinocytes that stabilize migratory protrusions and sustain long-distance #migration as they colonize the #epidermis. rupress.org/jcb/article/...

T-cell immunoglobulin and mucin domain-containing protein 3–mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne - Molecular Biomedicine Acne vulgaris is a common chronic inflammatory skin disorder with significant clinical and societal impacts. Severe acne (SA), in particular, causes scarring, disfigurement, and psychosocial distress....

#Research
T-cell immunoglobulin and mucin domain-containing protein 3–mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne doi.org/10.1186/s435...

#SevereAcne #TIM3 #SingleCellTranscriptomics #Macrophages #Keratinocytes

Chromatin accessibility profiling of #keratinocytes from clinically healed psoriatic skin reveals #epigenetic alterations https://ow.ly/9Ee950XplAu #medderm #psoriasis #dermsky

#Keratinocytes as key players, not bystanders, in #psoriasis: loss of function of an epithelial-specific transcription factor may drive disease https://ow.ly/STQG50XaySs #medderm #dermsky

Summary Journal of Cell Science: Cell Volume Regulates Terminal Differentiation Of Cultured Human Epidermal Keratinocytes
#cellscience #cell #biology #Epidermal #Keratinocytes #nursing #biology #EpidermalKeratinocytes #cellvolume

www.stuvia.com/doc/9207081/...

Read Neto et al's paper in the May issue:
Photoprotective #Melanin Is Maintained within #Keratinocytes in Storage #Lysosomes.
doi.org/10.1016/j.ji...
and
Salavessa et al's Commentary:
Trash to Treasure: The (Trans)formation of Pigment Organelles in Skin Keratinocytes
doi.org/10.1016/j.ji... #dermsky

T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts T cells and structural cells coordinate appropriate inflammatory responses and restoration of barrier integrity following insult. Dysfunctional T cells precipitate skin pathology occurring alongside a...

Today, in #preprinthub2 Kveta will discuss a #preprint from Peter Morawski lab @benaroyaresearch.bsky.social about how T cells promote distinct transcriptional programs of cutaneous inflammatory disease in #keratinocytes and dermal fibroblasts.🖖🕹️📱 #immunosky

www.biorxiv.org/content/10.1...