T-cell immunoglobulin and mucin domain-containing protein 3–mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne - Molecular Biomedicine Acne vulgaris is a common chronic inflammatory skin disorder with significant clinical and societal impacts. Severe acne (SA), in particular, causes scarring, disfigurement, and psychosocial distress....

#Research
T-cell immunoglobulin and mucin domain-containing protein 3–mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne doi.org/10.1186/s435...

#SevereAcne #TIM3 #SingleCellTranscriptomics #Macrophages #Keratinocytes

First-in-human phase I open-label study of the anti–TIM-3 monoclonal antibody INCAGN02390 in patients with select advanced or metastatic solid tumors T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3) is an immune checkpoint receptor upregulated during anti-programmed death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) immunot...

🧐Anti #TIM3 is #underwhelming in a phase I #clinicaltrial in #cancer #patients!
😓Not surprising! Without #personalised & #rationale combos, that correctly exploit TIM3 #Immunology, anti-TIM3 will fail!
👉We reported this recently: www.science.org/doi/full/10....
pmc.ncbi.nlm.nih.gov/articles/PMC...

Seeds of #Metastasis Identified

A study published in @cp-cancercell.bsky.social identifies #TIM3 as a new target to prevent metastasis in #breastcancer before it develops

Led by @tceliaterrassa.bsky.social and Catalina Rozalén

#CancerResearch #TalentMAR

researchmar.net/news/736/see...

Beyond T cell exhaustion: TIM-3 regulation of myeloid cells We provide a comprehensive review of 20 years of research on TIM-3 functions in myeloid cells and T cell exhaustion.

@dixon-lab.bsky.social, Gonzalo Fernandez Lahore, & @kuchroolab.bsky.social discuss the emerging roles for #TIM3 in regulating #MyeloidCell #immune responses!

#review #COVID19 #TIM3

TIM3 in COVID-19; A potential hallmark? (Šácha) - HeliyonJournal: doi.org/10.1016/j.he...

@iocbprague.bsky.social #charlesuniversity @czechacademy.bsky.social

Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.

In #ScienceImmunology last week, Zhang & al reported that the stability & expression of #ImmuneCheckpoint molecule #TIM3 is regulated by palmitoyltransferase DHHC9. Peptidic inhibitor of DHHC9 accelerates TIM-3 degradation & enhances #CARTCell & #NKCell #antitumor immunity!

bit.ly/SI_adp7302