This review highlights the CD47‑SIRPα axis as a key #ImmuneCheckpoint in #lymphoma, detailing current therapeutic strategies, including #FcFusionProteins and #peptides, and underscores their potential in treating Hodgkin and #NonHodgkinlymphomas.

#OpenAccess: doi.org/10.1016/j.ge...

Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement and its regulation by non-degradative polyubiquitination within the tumor microenvironment. The findings highlight...

This week #JournalClub @labsoap.bsky.social #LAG3 #immunecheckpoint @cellpress.bsky.social www.cell.com/cell/fulltex...

How do SSRIs affect #ImmuneCheckpoint blockade?

A team at UCLA showed that inhibiting serotonin transporter enhanced T cell antitumor immunity in mouse syngeneic & human xenograft models.

🖇️ bit.ly/43PS5Ls
🗨️ bit.ly/43NmHO0

Exciting read! Most downloaded article!

This review provides a comprehensive understanding of the #ImmuneMicroenvironment in #endometrialcarcinoma (EC) and elucidates the composition and functions of tumor-infiltrating immune cells. #ImmuneCheckpoint #medsky

#OpenAccess: buff.ly/KxlgQHt

The final results of the practice-changing clinical trial in first line treatment of patients with advanced #melanoma: CheckMate 067.

💊 Combination of anti-PD1 + anti-CTLA-4.

#CancerImmunotherapy
#ImmuneCheckpoint

Crystal structure of the human LAG-3–HLA-DR1–peptide complex The structural basis of how the immune checkpoint molecule LAG-3 binds peptide HLA-II is resolved.

This week in #Science #Immunology: Jan Petersen, Jamie Rossjohn, & colleagues have solved the #CrystalStructure of human #LAG3 – #HLADR1 – #peptide complex, a major target of #ImmuneCheckpoint #therapy!

Awesome review on combination strategies with ICB #CancerImmunotherapy #ImmuneCheckpoint

Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.

In #ScienceImmunology last week, Zhang & al reported that the stability & expression of #ImmuneCheckpoint molecule #TIM3 is regulated by palmitoyltransferase DHHC9. Peptidic inhibitor of DHHC9 accelerates TIM-3 degradation & enhances #CARTCell & #NKCell #antitumor immunity!

bit.ly/SI_adp7302

New analysis module!📊

Explore the prevalence, variety and distribution of predicted neoantigens in datasets of response to #ImmuneCheckpoint Inhibitors therapy #Immunotherapy #immunogenomics

The CRI iAtlas Immune Features module displays the distribution of immune readouts across your selected groups. In the image, we can see the estimates of T Cells CD4 for 5 datasets, with samples grouped based on the response to #ImmuneCheckpoint Inhibitor therapy. #immunotherapy

The CRI iAtlas Immune Features module displays the distribution of immune readouts across your selected groups. In the image, we can see the estimates of T Cells CD4 for 5 datasets, with samples grouped based on the response to #ImmuneCheckpoint Inhibitor therapy. #immunotherapy

Check out this thread detailing the latest paper out of the Devil Lab where we investigated more #immunecheckpoint interactions 👇#TassieDevil #transendocytosis #cancer

x.com/WildImmunity/s… doi.org/10.1016/j.dci.…