Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF Upstream open reading frames exert translational control of TNFR1, which limits tissue responsiveness to TNF.

Mutations in upstream open reading frames that regulate tumor necrosis factor receptor 1 (TNFR1) may contribute to disease symptoms in patients with autoinflammatory conditions like TRAPS.

Learn more in #ScienceImmunology: https://scim.ag/3PZOLdv

Copper supports regulatory T cell energetic state to sustain peripheral immune tolerance Slc31a1-mediated copper uptake maintains regulatory T cell function and peripheral immune tolerance.

A new #ScienceImmunology study finds that patients with rheumatoid arthritis have increased copper levels in regulatory T cells, which could guide new therapeutic strategies for autoimmune conditions.

Learn more: scim.ag/4m4vd3E

Copper supports regulatory T cell energetic state to sustain peripheral immune tolerance Slc31a1-mediated copper uptake maintains regulatory T cell function and peripheral immune tolerance.

A new #ScienceImmunology study finds that patients with rheumatoid arthritis have increased copper levels in regulatory T cells, which could guide new therapeutic strategies for autoimmune conditions. https://scim.ag/3O6hPzo

This month’s cover features a close-up image of a weathered bronze statue covered in copper patina.

The April 2026 issue of #ScienceImmunology is out!

This month's cover highlights how copper can "lend regulatory T cells a hand" by sustaining their metabolic fitness and peripheral immune tolerance. Learn more about this research and more: https://scim.ag/4sma5aU

Intestinal epithelial MHC class II induces encephalitogenic CD4 T cells and initiates central nervous system autoimmunity Intestinal epithelial cell MHC II is needed for induction of encephalitogenic CD4 T cells that migrate from gut to central nervous system.

A new #ScienceImmunology study highlights a gut–central nervous system pathway in autoimmunity, demonstrating that intestinal epithelial cells can promote the formation of pathogenic T helper 17 cells in the intestines. https://scim.ag/41umDSl

Immune mechanisms of congenital Zika syndrome This Review discusses both fetal and maternal immune responses that influence the development of congenital Zika syndrome.

A new #ScienceImmunology Review discusses the lessons learned from Zika virus infection research, including maternal-fetal immune crosstalk and potential strategies for therapeutic targeting. https://scim.ag/4sUInlV

Immunopathology in human tuberculosis The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

A 2024 #ScienceImmunology Review looked at immunopathology in human tuberculosis.

Learn more on #WorldTBDay: https://scim.ag/3NHahmG

Macrophages restrict tumor immune infiltration by controlling collagen topography In solid tumors, local fibrillar collagen topography is imposed by macrophages and dictates T cell infiltration and local accumulation.

Macrophages can restrict immune infiltration of tumors by inhibiting the formation of collagen III-rich networks that permit T cell and neutrophil entry.

Learn more in #ScienceImmunology: scim.ag/4sWKXIl

Macrophages restrict tumor immune infiltration by controlling collagen topography In solid tumors, local fibrillar collagen topography is imposed by macrophages and dictates T cell infiltration and local accumulation.

Macrophages can restrict immune infiltration of tumors by inhibiting the formation of collagen III-rich networks that permit T cell and neutrophil entry.

Learn more in #ScienceImmunology: https://scim.ag/4rFudEc

Inflammatory ILC2s migrate to distal tissues during infection using stage-specific S1P receptors ILC2s use multiple S1P receptors to migrate from the gut to distal tissues during helminth infection.

Group 2 innate lymphoid cells rely on specific receptors at different stages to exit the gut and travel to the lungs and other organs during helminth infections.

Learn more in #ScienceImmunology: https://scim.ag/4b7lDtc

Identification and characterization of dietary antigens in oral tolerance Immunodominant epitopes from seed storage proteins are a target of intestinal regulatory T cells that modulate immune challenge to food.

A new #ScienceImmunology study identifies intestinal regulatory T cells in mice that recognize common dietary grain proteins and promote immune tolerance, potentially preventing food allergies.

Learn more: scim.ag/4d2PmVe

Identification and characterization of dietary antigens in oral tolerance Immunodominant epitopes from seed storage proteins are a target of intestinal regulatory T cells that modulate immune challenge to food.

A new #ScienceImmunology study identifies intestinal regulatory T cells in mice that recognize common dietary grain proteins and promote immune tolerance, potentially preventing food allergies. https://scim.ag/4d2PR1y

This month’s cover features an image of flint corn, a frequently colorful variant of maize (Zea mays), that contains an immunodominant food epitope recognized by Treg cells.

The March 2026 issue of #ScienceImmunology is out!

This month's cover highlights how intestinal regulatory T cells in mice recognize food-derived antigens such as the maize protein αZein and suppress immune responses to them.

Learn about this research and more: https://scim.ag/4rL6F1I

Human LFA-1 governs T cell immune surveillance of the skin Human inherited integrin αL (CD11a) deficiency selectively impairs skin homing of T cells and surveillance of commensal papillomaviruses.

Deficiency in the leukocyte integrin LFA1 increases susceptibility to commensal human papillomaviruses (HPVs) by impairing T cell homing and surveillance in the skin. Learn more in #ScienceImmunology: https://scim.ag/3Mzi05P

Monocyte-derived IL-10 drives sex differences in pain duration Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

A new #ScienceImmunology study suggests that IL-10-producing monocytes help resolve pain faster in male mice and humans when compared with females, which could inform therapeutics for sex-specific pain conditions. https://scim.ag/40j6HSk

A figure depicting the cryo-EM structure of the V033-a.I1 antibody in complex with a stabilized Q23.MD39 trimer aligned to the structure of the mature V033-a.01 bNAb.

Two new animal studies in #ScienceImmunology show that B cell priming is key to induce broadly neutralizing antibodies (bNAbs) against HIV and demonstrate that a single immunization that targets bNAb precursors can induce potent neutralization.
📃: https://scim.ag/4ahapC0
📃: https://scim.ag/4raNMVz

Immunobiology of the serous cavities Local immune function and cross-tissue communication in the serous cavities are reviewed.

A new Review discusses the immune makeup within the peritoneal, pleural, and pericardial cavities, including changes that occur during conditions such as cancer and endometriosis.

Learn more in #ScienceImmunology: https://scim.ag/4aeAAYr

Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response.

Patients with ulcerative colitis have fewer protective γδ intraepithelial lymphocytes and higher numbers of inflammatory γδ T cell subsets, but show a reversal in distribution when in remission.

Learn more in #ScienceImmunology: https://scim.ag/4azeVvu

This month’s cover illustration depicts the extrusion of DNA loops by cohesin (green) until halted by CCCTC-binding factor (orange).

The February 2026 issue of #ScienceImmunology is out!

This month's cover highlights how the cohesin complex shapes genome organization in dendritic cells to regulate their differentiation and function. https://scim.ag/4agVpT8

Excited to share our work published yesterday (and featured on the cover!) of #ScienceImmunology. This was a true team effort between the Reizis lab at NYU @uchicagocoi.bsky.social and Sasha Galitsyna & Leonid Mirny at MIT 1/
www.science.org/doi/10.1126/...

Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling Preclinical modeling of human IgG–based drugs is enhanced through humanized Fcγ receptor and FcRn expression in a murine knockin model.

A new #ScienceImmunology study highlights the limitations of preclinical models for human antibody-based drugs, and demonstrates how a humanized mouse model may improve study outcomes. https://scim.ag/4t2ye7T

Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust mite throughout sexual maturation.

A new #ScienceImmunology study finds that epidermal growth factor receptor signaling exacerbates type 2 immunity in female mice exposed to house dust mites, and may drive sex differences in asthma. https://scim.ag/4qCYioq

Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust mite throughout sexual maturation.

Hello world, it's a g̶i̶r̶l̶/̶b̶o̶y̶ PhD baby 🎉

Very elated, proud (and relieved!) to announce that my PhD work is now out in @science.org #ScienceImmunology 👇 www.science.org/doi/10.1126/...

Read to find out how we made EGFR sexy again! 💃

Thanks to all involved @lloydlab.bsky.social 🙏

Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival Mycobacterial α-glucans target dectin-1, altering phagosomal maturation and enhancing intracellular bacterial survival.

A new #ScienceImmunology study shows that mycobacterium tuberculosis can survive within macrophages by binding dectin1 and altering phagosome maturation and autophagy. https://scim.ag/4pqax6f

Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.

Crosstalk between commensal E. coli that express flagellin and intestinal epithelial cells coordinate intestinal macrophage recruitment to support gut barrier homeostasis in mice.

Learn more in #ScienceImmunology: scim.ag/4pE9KPf

Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.

Crosstalk between commensal E. coli that express flagellin and intestinal epithelial cells coordinate intestinal macrophage recruitment to support gut barrier homeostasis in mice.

Learn more in #ScienceImmunology: https://scim.ag/4qV9TPl

Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.

Researchers from the lab of MSK immunologist Dr. Gretchen Diehl are shedding new light on how intestinal stem cells sense microbes and protect the gut. Read their new study, just out in @science.org #ScienceImmunology.

#Immunology #MSKCC #ScienceImmunology #Gut #Microbes @science.org @mskcancercenter.bsky.social

The OAS–RNase L pathway: Insights from experiments of nature Human monogenic deficits or excesses in the OASs and RNase L, which reposition the OAS–RNase L pathway as a regulator of inflammation, are reviewed.

A new #ScienceImmunology Review explores the context-dependent function of the OAS-RNaseL pathway, which can limit postviral inflammation during SARS-CoV-2 infections but restricts viral replication during other infections. https://scim.ag/3L9iL4S

Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia SFB colonization phenotypically alters alveolar macrophages, maintaining their antibacterial functions in inflamed interferon-rich lungs.

Gut bacteria protect mice infected with influenza A virus from secondary bacterial lung infections such as bacterial pneumonia.

Learn more in #ScienceImmunology: https://scim.ag/4jgo7HS