Crystal structure of the human LAG-3–HLA-DR1–peptide complex The structural basis of how the immune checkpoint molecule LAG-3 binds peptide HLA-II is resolved.

This week in #Science #Immunology: Jan Petersen, Jamie Rossjohn, & colleagues have solved the #CrystalStructure of human #LAG3 – #HLADR1 – #peptide complex, a major target of #ImmuneCheckpoint #therapy!