A decade with fraud at the #China #Pharmaceutical #University:
pubpeer.com/search?q=han...

Several of her new #peptide drugs and related patents have been successfully transformed, with some having entered #clinical #research.

Orally Bioavailable Cyclin A/B RxL Inhibitors: Optimization of a Novel Class of Macrocyclic Peptides That Target E2F-High and G1–S-Checkpoint-Compromised Cancers Cyclins A and B bind and activate their cognate cyclin-dependent kinase (CDK) to regulate progression through the S and G2/M phases of the cell cycle, respectively. Cyclins recruit substrates and regu...

pubs.acs.org/doi/10.1021/...

As a former #peptide chemist turned small mol chemist, I know this took tons of work. Lessons learned re: peptides:

- ⬆️Lipophilic = better always, generally
- PPB may be key
- PK = major issue

Also SPR exp w/ cyclins...would love to know the method

Professor Hanmei Xu, #China #Pharmaceutical #University

Several of her new #peptide drugs and related patents have been successfully transformed, with some having entered #clinical #research.

She is also a fraudster:
pubpeer.com/search?q=Han...
@frontiersin.bsky.social

Plant hormone and peptide signaling converge in the genetic network regulating cambium activation in Arabidopsis roots An intertwined network of cytokinin, auxin and peptide hormone signaling activates secondary growth in the Arabidopsis roots.

Plant #hormone & #peptide signaling converge in the #genetic network regulating #cambium activation in #Arabidopsis #roots

academic.oup.com/plcell/advan...

#PlantScience @theplantcell.bsky.social @apmahonen.bsky.social @srobertgroup.bsky.social @plantteaching.bsky.social @plantophagy.bsky.social

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosteron...

#Article in #MedComm

A Novel #Peptide, #HS1002, Enhances #Antitumor Activity via Dual Targeting of the #GnRH Receptor and Human #Telomerase Reverse Transcriptase in Prostate Cancer Cells doi.org/10.1002/mco2...

Research team from Sungkyunkwan University

#hTERT #ImmuneResponse #ProstateCancer

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#UltimaThymosinBeta4 #InjuryRecovery #TB500 #Peptide #UltimaThymosinBeta4forSale

Comprehensive synthesis of K48/K63 ubiquitin pentamers by graph-empowered automation | ChemRxiv Linear, branched, and heterotypic ubiquitin (Ub) chains regulate essential cellular processes, yet their structural and functional analysis remains limited by the difficulty of preparing defined, homogeneous samples by chemical synthesis or biochemical ...

He also talked about the synthesis of defined ubiquitin multimers using a chemoenzymatic strategy. (2/2)
chemrxiv.org/doi/10.26434...
#ChemSky #SPPS #Peptide #DrugDiscovery #Ligation

How can peptide-based drugs be modified at a late stage for further biological evaluation?

At #Lunteren2026, Eva Meeus told us about her amazing work on modifying the skeleton of tryptophan in peptides through nitrogen atom insertion.

pubs.acs.org/doi/abs/10.1...
#ChemSky #ChemBio #Peptide

How can LDL-cholesterol ("bad" cholesterol) be lowered in patients? Danila Branca gave an exciting talk at #Lunteren2026 on the development of orally bioavailable, macrocyclic peptide-based inhibitors of PCSK9.

pubs.acs.org/doi/10.1021/...
#DrugDiscovery #Peptide #Macrocycle #Cholesterol #PCSK9

Wellness peptide craze: why people are injecting drugs 'not for human consumption' Growing numbers of people are injecting unregulated peptides for health reasons - but one expert says they are "lab rats".

Longevity craze + celeb endorsements + exploitive wellness influencers + RFK Jr push = UGH! 🚨

Wellness #peptide craze: Why people are injecting? www.bbc.com/news/article...

"The people using these products are, in essence, becoming lab rats."

Soon: on CTV Edmonton to talk peptides...

Original post on mastodon.social

5-Mar-2026
Toxic #evolution: How #wasps and #frogs mimic #pain molecules to deter predators
Certain species of wasps and frogs share a pain and inflammation #peptide similar to one found in vertebrates to help defend against #predators – a discovery researchers say contributes to a shifting view […]

Had a great time at the 17th German #Peptide Symposium! Lots of interesting science and engaging conversations 🤩

I was happy to share my own work, and even won a poster prize! 🎉

👏🏻 A special thanks goes to all of the organisers that made the symposium a truly engaging event!

#17GPS

SiR‐XActin: A Fluorescent Probe for Imaging Actin Dynamics in Live Cells SiR-XActin is a far-red fluorescent probe for live-cell imaging of actin that avoids genetic modification and minimizes disruption of actin dynamics, due to its lower binding affinity. Based on jaspl...

Day 3 of the #Peptide Symposium began with a talk from our keynote speaker Hans-Dieter Arndt from @uni-jena.de. The talk focussed on the synthesis and investigations of (and with) cyclodesipeptides. Want to know more about SiR-XActin? doi.org/10.1002/anie...

1/3

#17GPS

And just like that, Day 2 of the #Peptide Symposium is almost over! Only one more day left! With that, we already want to say thank you to all the speakers and attendees for making this a truly engaging symposium! Now let’s head to the conference dinner.

#17GPS

Beta-Amyloid (1-42), HFIP High quality recombinant Beta-Amyloid (1-42), HFIP, >97% purity. Highly monomeric, batch to batch consistency. Order online today - R&D starts at rPeptide.

Check out rPeptide's Beta-Amyloid 1-42 HFIP (Cat # A-1163) t.ly/KAT-q

For a quote, please reach out to Sales@rPeptide.com today!

#Amyloid #BA #HFIP #BetaAmyloid #Peptide #AlzheimersResearch #rPeptide

After a warm welcome to Essen from Markus Kaiser and our @unidue.bsky.social Rector Barbara Albert, the 17th German #Peptide Symposium begins!

#17GPS

📆 Today is the day! The 17th German #Peptide Symposium starts this afternoon at 4 pm in Essen @unidue.bsky.social

☕ Make sure to arrive around 3 pm for the registration and coffee

🔗 The program for the whole symposium can be found here www.uni-due.de/imperia/md/i...

#17GPS

Are you on a peptide? Do you want to be? What about a statin? Read my latest Substack! open.substack.com/pub/mdlongevitylab/p/the... #peptide #longevity #healthspan #cognitivebias #evolution

For those curious to experience the #PDRN effect firsthand, the #Medicube PDRN Pink #Peptide #Serum offers an accessible yet sophisticated entry point.

CLICK HERE: www.bangstyle.com/posts/pdrn-r...

Very much looking forward to next week’s #Peptide Symposium!

#17GPS

📆In just one week, we will be hosting the 17th German #Peptide Symposium in Essen @unidue.bsky.social!

We are excited to host an open-topic event on modern peptide chemistry with a fantastic line up of speakers.

#17GPS

1/3

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