A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensin…

#WeekendRead! #InterferonPower! Dunphy @sancholab.bsky.social &co show @cp-immunity.bsky.social that in #macrophages, STING leads to type I #IFNs & ISG15-dependent ISGlatyion of mitochondrial proteins, increasing efferocytosis & driving epigenetic remodeling thus supporting inflammation resolution!

B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells B cells transiently increase interleukin (IL)-2 receptor expression upon activation. Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis that promotes the differentia...

#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper 🤗! www.cell.com/immunity/ful...

Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

#WeekendRead! #InterferonPower! Lin, Sayour, Grippin &co show @nature.com that SARSCoV2 #mRNAvaccines potentiate in cancer patients & mouse models immune checkpoint blockade anti-tumor therapy thanks to increased type I interferon signaling! www.nature.com/articles/s41...

Integrin CD103 expression in naive CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function Integrin CD103 mediates memory T cell tissue residency by binding E-cadherin-expressing epithelial cells, but why CD103 is also expressed on circulating naive CD8+ T cells has been unclear. Li et al. ...

#InterferonPower! Li, Park &co show @cp-immunity.bsky.social that IL-15 negatively regulates CD103 expression on CD8 T cells allowing formation of effector T cells & that engagement of CD103 on CD8 T cells by E-cadherin+ dendritic cells is necessary to drive memory formation via type I IFNs & IL-12

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...

#WeekendRead #InterferonPower! Hegde, @miriammerad.bsky.social &co show @nature.com that #tumor-derived factors drive NRF2 activation in bone marrow myeloid progenitors, dampening IFN-I/-III responses & favoring emergence of immunosuppressive monocyte-derived macrophages!

Interferons in health and disease The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Can’t wait to read this!! Sure to be a fantastic resource! #InterferonPower

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

#InterferonPower Immensely honored and excited to share our new review on all things Interferons out now in @cp-cell.bsky.social. Grateful to the brilliant & inspiring @lozanzi.bsky.social for the chance to contribute!
Check it out! authors.elsevier.com/c/1leKGL7PXu...

Threonine phosphorylation of STAT1 safeguards gut epithelial integrity and restricts interferon-mediated cytotoxicity | PNAS Barrier tissues such as the intestine are constantly challenged by environmental stressors and must adapt to maintain integrity and prevent excessi...

#InterferonPower #NoTimeToDie! Kishimoto &co identify @pnas.org a STAT1 phosphorylation site that boosts integrin b4 in intestinal epithelial cells & prevents its downmodulation by IFNs, thus mitigating IFN cytotoxic & damaging functions, preserving barrier integrity! doi.org/10.1073/pnas...

MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction Necroptosis drives inflammation through membrane rupture-mediated DAMPs release. Independently of membrane damage, Ding et al. revealed phosphorylated MLKL permeabilizes mitochondrial membranes and in...

#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @cp-molcell.bsky.social that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! www.cell.com/molecular-ce...

Systemic inflammation impairs myelopoiesis and interferon type I responses in humans - Nature Immunology Stunnenberg et al. use a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppr...

#WeekendRead! #InterferonPower! Stunnenberg Pickkers Kox, Keramati &co show @natimmunol.bsky.org that 2 LPS injections in volunteers mimic the proinflammatory & immunosuppressive phases of #sepsis & found that IFNb treatment restores immune responsiveness in the suppressive phase!

Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-λR1) and IFN-λ Signaling in Influenza A Virus (IAV) Infection

#InterferonPower! Zhou &co show @elife.baky.social that a phospholipid scramblase is upregulated in response to interferon lambda #IFNL, and works as a transcription factor to upreg IFNLR in lung epithelial cells, protecting against influenza A virus! doi.org/10.7554/eLif...

A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer Acha-Sagredo et al. stratify colorectal cancers using features of an immune-reactive tumor microenvironment. This microenvironment, locally abundant in cytotoxic lymphocytes and antigen-presenting mac...

#WeekendRead. #InterferonPower. Ciccarelli &co show @cp-cancercell.bsky.social that an #interferon signature in macrophages & T cells during #colorectal #cancer leading to CD74 upregulation identifies patients responding to immune checkpoint inhibition therapy. #ScienceSavesLives dlvr.it/THwNgQ

Postdoc or PhD student opportunity 👇👇👇 All about #InterferonPower, what else?! 😉

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...

#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance

Cellular RNA interacts with MAVS to promote antiviral signaling Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

#InterferonPower! Fantastic @science.org by @nandangokhale.bsky.social @ramlabuw.bsky.social &co! MAVS is intrinsically capable to sense via an unstructured region the 3’ UTRs of self mRNA (ISGs too!) to potentiate the response to viral RNA via phosphorylation of IRF3 & NFkB!

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity | Journal of Experimental Medicine | Rockefeller University Press This study identifies 11 IFNAR1 alleles impairing IFN-α/ω responses but sparing IFN-β, including an allele common in Southern China (P335del). Heterozygous

#InterferonPower! #NotAllIFNsAreEqual! Casanova, Zhang, Al Qureshah &co show @jexpmed.bsky.social that a common (in China) autosomal dominant IFNAR1 variant impairs -not abolishes- IFN-alpha & -omega (not -beta!) responses making patients susceptible to some -not all- viruses doi.org/10.1084/jem....

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...