A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity | Journal of Experimental Medicine | Rockefeller University Press This study identifies 11 IFNAR1 alleles impairing IFN-α/ω responses but sparing IFN-β, including an allele common in Southern China (P335del). Heterozygous

#InterferonPower! #NotAllIFNsAreEqual! Casanova, Zhang, Al Qureshah &co show @jexpmed.bsky.social that a common (in China) autosomal dominant IFNAR1 variant impairs -not abolishes- IFN-alpha & -omega (not -beta!) responses making patients susceptible to some -not all- viruses doi.org/10.1084/jem....