A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensin…

#WeekendRead! #InterferonPower! Dunphy @sancholab.bsky.social &co show @cp-immunity.bsky.social that in #macrophages, STING leads to type I #IFNs & ISG15-dependent ISGlatyion of mitochondrial proteins, increasing efferocytosis & driving epigenetic remodeling thus supporting inflammation resolution!

#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis Although the immune system is a significant barrier to tumor growth and spread, established tumors evade immune attack and frequently colonize immune …

#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!

Wow, I didnt know the timeline would be this tight, #immunology post docs interested in 2yr impact+ award if graduated with PhD in last 2 yrs & currently outside 🇨🇦, we need to nominate by Jan 15th! So if interested in #IFNs, #IBD, #immunoregulation, get in touch ASAP as this will be competitive! 🤞🙏🏻😊

Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development Single-cell transcriptomics identifies type I and II interferons as regulators of cortical and medullary thymic epithelial differentiation.

In #Science #Immunology, researchers at @stanfordmedicine.bsky.social studied #IFNs in human #fetal #thymus development. They found type I & II IFNs play distinct but critical roles in cortical & medullary thymic #EpithelialCell differentiation!

Congrats to Julian and others from @ramlabuw.bsky.social on this cool work that finds that the loss of the RNA-binding protein CELF2 leads to accumulation of endogenous RIG-I ligands! #RNA #innateimmunity #IFNs

Officially official 🥳🎉🥂
5yr #CIHR grant celebrations today with #SanterLab & Murooka lab who also got their grant (as co-I some #IFNL too 😉)
#IBD #IFNs #immunology

So thankful to our co-Is, collabs & all in our lab + #sisterlab who worked hard to help get this funded🙏🏻
@umanitoba.bsky.social

3/4 #IFNs - intentional fake news
How: Pick one of the many ridiculous events we are hearing about and ridicule what is happening with an intentional face news (marked as fake news)

Quick guide / overview for

#cts = change the story, shape the world, #MiHS - make it happen stories, #IFNs - intentional fake news, alternative reality

Details in thread 🧵

#IFNs #pbfc 🧵

‘You know,’ Alice interrupted his thoughts, ‘maybe we should fight back after all.’
‘What do you mean?’
‘The smear campaign people invent stories to harm us.’
‘Yes?’

#IFNs #pbfc

Is it possible to defuse fake news by countering them with intentional fake news? For more see: #IFNs

#IFNs #pbfc

Intentional fake news

You could argue that all fake news are intentional, but if I mark my news piece as fake news, then it can become a parody of fake news.

8/18 - alternative reality
A person/group can be ridiculed with stories or #IFNs which depict an alternative reality, most effectively with an element of the absurd.

Case: A president announces expansion phantasies. In the alternative reality, the same president dissolves their nation.

7/18 - #IFNs - intentional fake news
Intentional fake news are fake news which are marked as fake news and are intended to ridicule both the practice of producing fake news and the person or group the IFN is about.

For more see #IFNs

I hope 2025 brings the same engagement here as #ScienceTwitter used to be🤞🤞
#TwitterWrapped nicely summarized my Twitter account 👇👇

Not surprising to see #science #research #IFNs #SanterLab as a focus + of course #scicomm 🥳😀👩‍🔬

Had fun today giving a seminar describing our past 4yrs of research from the #SanterLab from #COVID19 to #immunoregulation to #IBD, with a common theme of #IFNs 😀🥳
There were ups & downs, but many great memories so far.

Thanks to my awesome team & colleagues, funders + many collabs 🙏🏻

Rab8a restores diverse innate functions in CD11c+CD11b+ dendritic cells from aged mice - Nature Communications Identifying molecular regulators of immune aging is necessary to improve the response to infections and vaccine efficacy in aged hosts. Here, by exploring the age-related alterations of immune cells t...

#WeekendRead! #LiveForever! Sehrawat &co show @ Nature Communications that aged dendritic cells #DCs produce less type I #IFNs in response to IAV & do not efficiently activate CD8 T cells! Rab8a over expression boosts Ag cross presentation restoring DC functions! www.nature.com/articles/s41...

Poster announcing seminar by Dr. Deanna Santer December 5, 2024 at 1pm at the University of Manitoba Bannatyne campus.

Finally giving a seminar to my own #immunology dept next week Dec 5 🥳
Now while it is in-person only in Winnipeg🇨🇦 so some here cannot join, I am happy to chat about #IFNs & esp #IFNLs anytime! #interferosky 😊
@um-radyfhs.bsky.social

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...