Precancerous niche remodelling dictates nascent tumour persistence - Nature A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlyin...

#WeekendRead! #SmartTumor! #EveryCellIsAnImmuneCell! Amazing work @nature.com by @mariapalcolea.bsky.social Skrupskelyte, Rojo &co showing the stress response driven by nascent tumors induces a wound healing program in surrounding fibroblasts driving a #PreCancerousNiche that fosters tumorigenesis!

Mitochondrial transfer from immune to tumor cells enables lymph node metastasis Although the immune system is a significant barrier to tumor growth and spread, established tumors evade immune attack and frequently colonize immune …

#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!

Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors GPX4 released by ferroptotic cancer cells suppresses dendritic cell maturation and T cell priming by binding to ZP3. Blocking the GPX4-ZP3 interaction restores dendritic activity, boosts cytotoxic T c...

#WeekendRead! #SmartTumor! Liu, Kroemer, Tang, Wang &co show @cp-cell.bsky.social that ferroptotic tumor cells release GPX4 dampening anti-tumor responses by signaling in DCs via ZP3 receptors, thus blocking glycolysis & impairing cytotoxic T cell activation!
www.cell.com/cell/abstrac...

HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded large EVs, known as melanosomes, that directly engage and impair CD8+ T cell receptors.

#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...

Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion - Nature Immunology Huang and colleagues report that TIM4–AMPK signaling induces downregulation of the mitochondrial HSP90 chaperone TRAP1 in tumor-associated macrophages, thereby enhancing their immunoinhibitory functio...

#WeekendRead! #SmartTumor
Zhao, Huang &co show @natimmunol.nature.com that within tumormicro environment, sensing of dead cells by macrophages via TIM4 inhibits a mitochondrial chaperone protein enhancing mitochondrial functions & epigenetically enforcing immunesuppression doi.org/10.1038/s415...