MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC gl…

#WeekendRead #MysterySolved! MYC is one of the most famous #oncogenes & a potential therapeutic target but how does it work? Uhl, Eilers &co show @cp-cell.bsky.social that MYC binds introns during RNA stalling preventing export of dsRNA & DNA/RNA hybrids & anti-tumoral TLR3 activation!

Synapse: Your Connection to our MSK Authors
Meet: Chiara Mastroleo
Research Focus: Cancer Biology and Genetics; Research Assistant

Engineered extrachromosomal oncogene amplifications promote tumorigenesis
synapse.mskcc.org/synapse/work...

#CancerResearch #Oncogenes #BiomedicalResearch

#OncostatinM induced by STAT5-activating #oncogenes triggers STAT-3-mediated proinflammatory signaling, resulting in #MetabolicReprogramming, enhanced cytokine secretion, and recruitment of #Immunosuppressive myeloid cells in blood malignancies.

#OpenAccess: doi.org/10.1038/s413...

Gregory J. Morgan, Cancer Virus Hunters: A History of Tumor Virology Baltimore: Johns Hopkins University Press, 2022. Pp. 392. ISBN 978-1-4214-4401-7. $50.00 (hardcover). | The British Journal for the... Gregory J. Morgan, Cancer Virus Hunters: A History of Tumor Virology Baltimore: Johns Hopkins University Press, 2022. Pp. 392. ISBN 978-1-4214-4401-7. $50.00 (hardcover).

A thoughtful review of Cancer Virus Hunters in BJHS by
@ctimmermann.bsky.social
#cancer #historyofbiology #tumorvirology #HPV #cancervaccine #oncogenes #historyofscience #historyof20thcentury
www.cambridge.org/core/journal...

#CellSignalling pathways are how cells react to outside stimulus. Compare & contrast the #adrenaline (#epinephrine) & #ReceptoryTyrsoneKinase (#RTK) pathways with our paper models! Find out more here:
Adrenaline: buff.ly/s1RBwiE
RTK: buff.ly/eRW542O

#EduSky #oncogenes #gprotein #cyclicamp

How do cells know when to divide? The Receptor Tyrosine Kinase (RTK) signalling pathway! See how it works in a clear way & how cancer can be caused when it goes wrong. Learn more here: buff.ly/VRlEEyc

#EduSky #iteachbio #RTK #ras #raf #oncogenes

Dysregulation of mRNA splicing in urothelial carcinoma: Clinical, diagnostic and therapeutic implications
Bladder Cancer
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#tumormicroenvironment #oncogenes #tumorsuppressors #oncology #cancerresearch #openaccess

Epstein-Barr virus protein EBNA1 upregulates oncogenes in cervical cancer cells BUFFALO, NY- August 22, 2025 – A new research paper was published in Volume 16 of Genes & Cancer on August 6, 2025, titled “Epstein-Barr virus nuclear antigen 1 upregulates Derlin1 and PSMD10…

#Epstein-Barr #virus #protein upregulates #oncogenes in #cervical #cancer cells ...

| #EpsteinBarrVirus | #EBNA1 | #EBV | #HPV | Via eurekalert .org

EcDNA, circular DNA molecules found outside chromosomes in cancer cells, differ from chromosomal DNA in lacking centromeres. This results in uneven segregation during cell division and the rapid amplification of #oncogenes.

Extrachromosomal DNA Understand the biology of ecDNA generation and action, and develop approaches to target these mechanisms in cancer. This challenge is being tackled by team eDyNAmiC.

pmc.ncbi.nlm.nih.gov/articles/PMC....

videocast.nih.gov/watch=54628
Extrachromosomal DNA, small DNA circles separate from the main chromosomes, can carry #oncogenes & amplify them, driving cancer growth & making it more resistant to treatment.

Disruption of TAD hierarchy promotes LTR co-option in cancer - Nature Genetics NIPBL perturbation activates long terminal repeat (LTR)-derived alternative promoters due to reorganization of chromatin’s hierarchical structure, leading to LTR co-option and oncogene activation in m...

#TransposableElements altho abundant in the human genome, are repressed by methylation and chromatin modifications.

Here authors show another mechanism of repression; hierarchical chromatin topology (TADs) - when disrupted they can lead to co-option of LTRs as alternative promotors of #oncogenes!

#Regulation #SustainedSignaling #DeNovoSysthesis #Oncogenes #CancerResearch #Plasticity
#Differentiation #Fibrosis #Inflammation #Selection
#Thermodynamics #Stability #Microbiome #Circadian
Thanks @peiferlabunc.bsky.social @slavov-n.bsky.social

Happy birthday to J. Michael Bishop! He won a #LaskerAward and a #NobelPrize for the discovery that #oncogenes are present in normal cells. @ucsfmedicine.bsky.social
https://buff.ly/3Q6Lxln
Read a feature on how he discovered the first #cancer-causing genes: https://buff.ly/42JXiG3 🧪

We also investigate the phenotypic heterogeneity of MCF10A human mammary gland #organoids expressing various #oncogenes, which is an #organoid model of #BreastCancer. #oncogene

Registration is open for a #Canadian classic. Signalling in Normal & Cancer Cells. #Science4All #ScienceSaves #ScienceIsFun #SignalTransduction #scRNAseq #ModelSystems #kinases #oncogenes #cytoskeleton #CellCycle #Chromatin #epigenetics
@cdnwomenstem.bsky.social

event.fourwaves.com/banffsncc202...

Chromosomes dyed with DAPI (blue) have red florescence from cKIT-containing probes

Yay! I want to participate in #FluorescentFriday #FluorescenceFriday. These are old, from 2011 pub. Used #FISH to identify #canid #Bchromosome regions. In 3 canid species, Bchrs contained duplicated Achr material. #Vulpesvulpes #redfox #cKIT #oncogenes #raccoondogs #Chinese #Japanese #Nyctereutes