STAT5-activating oncogenes drive #OncostatinM production to remodel the bone marrow niche and induce #TCell exhaustion, identifying the OSM axis as a key target for treating aggressive hematologic malignancies. #Medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Integrating murine models and human #scRNAseq data reveals that neutrophil-derived #OncostatinM drives #AtopicDermatitis by promoting immune cell recruitment, skin inflammation, & #Pruritus-associated neuronal activation.

#OpenAccess: doi.org/10.1016/j.ge...

#OncostatinM induced by STAT5-activating #oncogenes triggers STAT-3-mediated proinflammatory signaling, resulting in #MetabolicReprogramming, enhanced cytokine secretion, and recruitment of #Immunosuppressive myeloid cells in blood malignancies.

#OpenAccess: doi.org/10.1038/s413...