Red blood cells undergo lytic programmed cell death involving NLRP3 Complement exposure induces programmed cell death of red blood cells due to the intracellular activation of miniNLRP3 and caspase-8. Inhibiting NLRP3 signaling reduces cytoskeletal damage and prevents...

#EveryCellIsAnImmuneCell!! #MiniNLRP3: welcome to #Spectosis! Liu, Hu &co show @cell-cellpress.bsky.social that #complement activation drives red blood cell #RBC death by activating a miniNLRP3-ASC-caspase8 complex, causing proteolysis of b-spectrin & sustaining autoimmune hemolytic anemia!