Professor Sendurai Mani on the Role of EMT and Stem Cells in Cancer Metastasis - Wafik S. El-Deiry
@weldeiry.bsky.social @brown.edu
oncodaily.com/voices/wafik...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #CancerMetastasis
#Targetome
TGFβ3 drives bladder cancer metastasis through succinate metabolism and stromal remodeling, with L-chicoric acid blocking this pathway 🧬🎯
Details: www.maxapress.com/article/doi/10.48130/tar...
#bladdercancer #remodeling #acid #cancermetastasis
Johns Hopkins Study Uncovers Master Gene Supercharging Pancreatic Cancer Metastasis #Science #HealthandMedicine #Oncology #PancreaticCancer #GeneResearch #CancerMetastasis
scitechdaily.com/johns-hopkins-study-unco...
#CyclicdiGMP suppresses #CancerMetastasis by directly targeting #PSMD3, disrupting its interaction with TBK1, and inhibiting NF‑κB signaling, thereby curbing metastatic #BreastCancer progression with minimal toxicity. @TulaneMedicine
#OpenAccess in #STTT: doi.org/10.1038/s413...
With deep expertise in protein chemistry, biophysics and EV technology, he now drives method development, managing key EV instruments, expanding isolation pipelines, and leading the local EV network at LiU.
#EVResearch #CancerMetastasis #PreMetastaticNiche
#SharingIsCaring or not? @nature.com #MitochondriaPower #CancerMetastasis #EveryCellIsAnImmuneCell
Scientists caught tumor clusters breaching blood vessels in real-time—exposing how cancer spreads and how we might stop it. #CancerMetastasis #TumorClusters #MedicalBreakthrough
Percutaneous Locoregional Therapies for the Treatment of Liver Metastases from Uveal Melanoma: A Systematic Review
@journals.sagepub.com @tcrtcancer.bsky.social
journals.sagepub.com/doi/10.1177/...
#cancermetastasis #cancerresearch #oncology #oncsky #openaccess @oncodaily.bsky.social
3Rs #Refinement with minimally invasive surgical techniques (...https://bit.ly/4kSYUmF https://bit.ly/4dObSjl
#3Rs #Refinement #AnimalWelfare #EthicalResearch #ImageGuidedSurgery #HighFrequencyUltrasound #NonInvasiveImaging #PreclinicalImaging #IntraCardiacInjection #CancerMetastasis #BoneMetastasis
📚 New Review now online
Interplay of integrins and selectins in metastasis
🔓 buff.ly/TAwbF4l
#Integrins #CellAdhesion #Selectins #CancerMetastasis
Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles
👉 buff.ly/hXoywDz
#Immunosuppression #CancerMetastasis #Immunomodulation
Enhancing Immunity to Fight Cancer Metastasis - Yan Leyfman
@yleyfman.bsky.social
oncodaily.com/blog/yan-ley...
#Cancer #CancerResearch #FightAgainstCancer #CancerMetastasis #Medicine #Health #Oncology #OncoDaily
Extracellular vesicles—a new player in the development of urinary bladder cancer - Therapeutic Advances in Medical Oncology - Jan 23, 2025 @journals.sagepub.com
journals.sagepub.com/doi/10.1177/...
#EVs #cancermetastasis #tumordevelopment #cancerresearch
Thank you to @sohailtavazoie.bsky.social @rockefelleruniv.bsky.social for presenting our #DistinguishedLecture. His talk covered emergent technologies in molecular #cancer biology and the genetic basis of #cancermetastasis.
Watch his full talk: youtube.com/watch?v=Ugmk....
🌟 Exciting news! The 10th International Congress on Cancer Metastasis is happening from October 29-31, 2025, in San Francisco! We’re looking for sponsors who want to make a difference in cancer research.
cancermetastasisconference.org/sponsors-and...
#CancerMetastasis #Sponsorship
4/6 Progression Outcomes:
🔍 Local progression-free survival (LPFS): 10.9 months on median
🔍 Distant progression in 4/6 patients
🔍 Reflects IRE's potential but indicates a need for broader studies
#CancerMetastasis #IR
🧪Very interesting findings with implications in #cancermetastasis 👇
#mechanotransduction
#cancerresearch
#ECMatrix
#integrins
Researchers develop new genetic model to decode breast cancer
yespunjab.com?p=58738
#BreastCancerResearch #GeneticModel #E2F5Gene #CancerMetastasis #OncologyResearch #BreastCancer #Cancer #Health
![Fig. 2|E-selectin induces NLRP3 inflammasome activation in neutrophils.
a. Schematic of the experi
eripheral blood mononuclear
cells. b,c, E-selectin-ind
assessed in isolated
human neutrophi
nimod/TAC242. PBS
(control), E-select
aquinimod/TAC242 (b)
and with PBS,
sence MCC950 (c). The amount
or Drocessed ca
determined in the
supernatones.
GAPDH was determined in
celllysates (n = « independent experiments): Pag, paguinimod. d-. Caspase] activity was determined in isolated human neutrophils stimulated with E-selectin or PBS (control) for 10 min loaded with FLICA dye and analyzed by confocal microscopy. Representative confocal images (d), quantification of mean FLICA*
(f; 76 (control) and 112 (E-selectin) cells of n = 3 independent experiments) are
shown. g. Isolated human neutrophils were treated for 10 min with PBS (control), E-selectin or E-selectin in the
and the amount of full-length
GSDMD (FL GSDMD)
determined in the cell lysates
(n =4 independent
ocalimages (h) and
overall MFl of G](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:wvmvjmwdooynkpxdwlghnvq6/bafkreiabosn5ym6orwf6f5qqc7xitaeqocp44jf4gafgmttr36o2zgqvyu)
Fig. 2|E-selectin induces NLRP3 inflammasome activation in neutrophils. a. Schematic of the experi eripheral blood mononuclear cells. b,c, E-selectin-ind assessed in isolated human neutrophi nimod/TAC242. PBS (control), E-select aquinimod/TAC242 (b) and with PBS, sence MCC950 (c). The amount or Drocessed ca determined in the supernatones. GAPDH was determined in celllysates (n = « independent experiments): Pag, paguinimod. d-. Caspase] activity was determined in isolated human neutrophils stimulated with E-selectin or PBS (control) for 10 min loaded with FLICA dye and analyzed by confocal microscopy. Representative confocal images (d), quantification of mean FLICA* (f; 76 (control) and 112 (E-selectin) cells of n = 3 independent experiments) are shown. g. Isolated human neutrophils were treated for 10 min with PBS (control), E-selectin or E-selectin in the and the amount of full-length GSDMD (FL GSDMD) determined in the cell lysates (n =4 independent ocalimages (h) and overall MFl of G
- S100A8/S100A9 serum levels are not only a biomarker but also a disease indicator of pathogenesis of various diseases #COVID19 , #chronic tuberculosis and #cancermetastasis
