Tamoxifen induces PI3K activation in uterine cancer - Nature Genetics Sequencing analysis of tamoxifen-associated uterine cancers and further in vivo analyses suggest that the drug tamoxifen can activate the PI3K pathway in the absence of oncogenic mutations.

Tamoxifen circumvents the need for genetic mutations in the PI3K signaling pathway by directly providing the stimulus for tumor development.

#oncology #tumordevelopment #breastcancer

doi.org/10.1038/s415...

Extracellular vesicles—a new player in the development of urinary bladder cancer - Therapeutic Advances in Medical Oncology - Jan 23, 2025 @journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#EVs #cancermetastasis #tumordevelopment #cancerresearch