Researchers identify #TRPV6 as a key driver of #ProstateCancer #BoneMetastasis via CaMK2/NF-κB signaling and TRPV6–CXCR4 complexes, showing that early TRPV6 inhibition and dual TRPV6/CXCR4 targeting can reduce metastatic risk. @univlille.bsky.social

#STTT: doi.org/10.1038/s413...

Progression and Metastasis of Lung Cancer: Clinical Features, Molecular Mechanisms, and Clinical Managements Lung cancer represents a significant global health threat. Despite progress in treatment, metastasis continues to present a major clinical challenge. This article reviews the metastases of lung cance...

#Review in @MedComm_MC
Progression and Metastasis of Lung Cancer: Clinical Features, Molecular Mechanisms, and Clinical Managements doi.org/10.1002/mco2...

#BoneMetastasis #BrainMetastasis #LiverMetastasis #LungCancer

Targeting TRPV6/CXCR4 complexes prevents castration-resistant prostate cancer metastasis to the bone - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Targeting TRPV6/CXCR4 complexes prevents castration-resistant prostate cancer metastasis to the bone

This study shows that #TRPV6 drives #bonemetastasis in CRPC by promoting EMT & CXCR4/TRPV6 complex formation, while dual targeting of TRPV6 and #CXCR4 synergistically suppresses metastasis & improves survival. @univlille.bsky.social #PCa

#STTT #OpenAccess: doi.org/10.1038/s413...

This review examines #TumorMetastasis, the mechanisms of organ-specific metastasis, and therapies, highlighting challenges & opportunities in #BoneMetastasis research and offering insights for future studies. @bcmhouston.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

3Rs #Refinement with minimally invasive surgical techniques (...https://bit.ly/4kSYUmF https://bit.ly/4dObSjl
#3Rs #Refinement #AnimalWelfare #EthicalResearch #ImageGuidedSurgery #HighFrequencyUltrasound #NonInvasiveImaging #PreclinicalImaging #IntraCardiacInjection #CancerMetastasis #BoneMetastasis

It's very unlikely that someone could get,
annual checkups & not notice a #PSA #elevation

With Biden #PSA score * #bonemetastasis
he had prostate cancer for years

Its repeat medical #malpractice or #coverup

Most older mens with #prostate #cancer
die by age, not by prostate cancer #complications

Impact of Bone Metastasis in Stage IV Non–Small Cell Lung Cancer Treated With Durvalumab and Tremelimumab With or Without Chemotherapy: A Retrospective Analysis of the CCTG BR.34 Trial | JCO Oncology ... PURPOSEThis retrospective analysis examines the impact of bone metastasis on outcomes in patients with non–small cell lung cancer (NSCLC) from the CCTG BR.34 trial, which investigated the combined imm...

MT ósea asoc c/peor resultado en pac c/CA pulmón no microcítico tratados c/durvalumab y tremelimumab, debe considerarse como factor de estratificación y terapias dirigidas a factores del microentorno óseo #bonemetastasis #NSCLC ascopubs.org/doi/full/10....