Researchers identify #TRPV6 as a key driver of #ProstateCancer #BoneMetastasis via CaMK2/NF-κB signaling and TRPV6–CXCR4 complexes, showing that early TRPV6 inhibition and dual TRPV6/CXCR4 targeting can reduce metastatic risk. @univlille.bsky.social

#STTT: doi.org/10.1038/s413...

Targeting TRPV6/CXCR4 complexes prevents castration-resistant prostate cancer metastasis to the bone - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Targeting TRPV6/CXCR4 complexes prevents castration-resistant prostate cancer metastasis to the bone

This study shows that #TRPV6 drives #bonemetastasis in CRPC by promoting EMT & CXCR4/TRPV6 complex formation, while dual targeting of TRPV6 and #CXCR4 synergistically suppresses metastasis & improves survival. @univlille.bsky.social #PCa

#STTT #OpenAccess: doi.org/10.1038/s413...