Maternal stress triggers early-life eczema through fetal mast cell programming - Nature Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to otherwise harmless mechanical friction after birth.

#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...

Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens Maternal antibodies fundamentally regulate gut immunity in the developing infant, yet the mechanisms underlying this process remain elusive. We found that maternal immunoglobulin G (IgG), ingested in ...

#WeekendRead! #MomIsAlwaysMom! Koch, Shenoy et al show @science.org that, in the first 7 days of life, breast milk IgGs (not IgAs!) recognize microbiota & limit, via Fc receptors, Tfh cell and B cell intestinal expansion, protecting against #colitis & #allergy during weaning!

Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

#WeekendRead! #MomIsAlwaysMom! Huang, Mass &co show @nature.com that obese moms reprogram kupffer cells #KCs of their progeny via glycolysis, favoring lipid uptake by hepatocytes & development of fatty liver disease which can be prevented deleting KCs or HIF1a! www.nature.com/articles/s41...

Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring Yao et al. demonstrate that maternal circadian rhythms during pregnancy impact placental signature and fetal rhythm. Diet-induced obesity in offspring is exacerbated by in utero chronodisruption. The ...

#WeekendRead! #MomIsAlwaysMom & #SleepWell! Yao, Itoh &co show @cp-cellmetabolism.bsky.social that mimicking a chronic jet lag in pregnant mice causes decrease fetal size & an offspring that is more susceptible to high fat diet induced #obesity! www.cell.com/cell-metabol...

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#WeekendRead! #MomIsAlwaysMom! Dang, Kundu &co show @ CellStemCell that maternal #microbiota imprints the neural and intestinal stem cell compartments of their offsprings via mTOR signaling, leading to long lasting reprogramming of brain & gut functions! Doi.org/10.1016/j.stem.2024.10.003

Prenatal antibiotics reduce breast milk IgA and induce dysbiosis in mouse offspring, increasing neonatal susceptibility to bacterial sepsis Up to one-third of women receive antibiotics during pregnancy. Pietrasanta et al. show that antibiotic treatment of pregnant mice reduces the amount of breast milk antibodies (SIgA) and alters the neo...

#MomIsAlwaysMom! Pietrasanta, Rescigno &co show @ Cell Host and Microbe that antibiotics treatment of pregnant mice decreases IgAs in the breast milk, causing lower IgA-coated #microbiota, long-lasting dysbiosis & susceptibility to bacterial sepsis!! www.cell.com/cell-host-mi...