Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance Cancer cells exploit distant tissues and organs to escape immune surveillance by activating nociceptive neurons, which remodel tumor-draining lymph nodes into an immune-suppressed state. Blocking this...

#WeekendRead! #EveryCellIsAnImmuneCell! #SmartTumors. Ji Zhang &co show @cp-cell.bsky.social that tumor cells undergo ER stress under immune pressure leading to activation of nociceptive neurons which signal in draining lymph node driving immune suppression via decreased CCL5 & favoring tumor growth