A population approach to cortical GABAergic interneuron function Inhibitory interneuron diversity is a central feature of cortical circuits. The IN-CODE consortium seeks to combine large-scale recordings of interneuron types with machine-learning tools to identify ...

A population approach to #cortical #GABAergic #interneuron function: Neuron www.cell.com/neuron/fullt...

Active dissociation of intracortical spiking and high gamma activity - Nature A brain–machine interface is used in monkeys to investigate the biophysical underpinnings of cortical high gamma-band activity, a signal that is often studied in the context of many brain functions.

Active dissociation of intra- #cortical #spiking and high gamma activity
doi.org/10.1038/s415...

Original post on webpronews.com

Biological Data Centers: Startups Are Building Computers Powered by Human Brain Cells Startups are building data centers powered by lab-grown human brain cells, betting that biological processors c...

#EmergingTechUpdate #AI #energy #consumption #biocomputing […]

[Original post on webpronews.com]

LATEST COVER IMAGE 📸

The latest issue of JP features imagery from Guanxiao Qi and colleagues' study into transport-related effects on intrinsic and synaptic properties of human #cortical #neurons 🧠

📖 Read the issue: physoc.onlinelibrary.wiley.com/toc/14697793...

Distinct interneuronal dynamics selectively gate target-specific cortical projections in drug seeking Jeong et al. show that interneuron- and projection-defined vmPFC sub-circuits differentially engage mesolimbic pathways to drive persistent cocaine seeking after abstinence. Distinct interneuron subty...

Distinct #interneuronal dynamics selectively gate target-specific #cortical projections in #drug seeking: Neuron www.cell.com/neuron/fullt...

Vectorized instructive signals in cortical dendrites - Nature Mice learning a neurofeedback brain–computer interface task show neuron-specific teaching signals in cortical dendrites, consistent with a vectorized solution for credit assignment in the brain.

"Here we used a neurofeedback brain–computer interface task... We trained mice to rotate a visual grating towards a target orientation while we recorded GCaMP activity..."🤯

Vectorized instructive signals in #cortical #dendrites
doi.org/10.1038/s415...

Dilek Ocal, Brian L. Day, Amy Peters, Matt Bancroft, David Cash, Diego Kaski, Natalie S. Ryan, Sebastian J. Crutch, Keir X. X. Yong find that #visual modulation of vestibular-evoked balance response is disturbed by posterior #cortical atrophy 👁️ 🧠

📜 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Wolfgang Taube & Benedikt Lauber from @uni-freiburg.de consider the evolution of the #ageing brain in relation to #cortical overactivation 🧠 ⚙️

Read the #TopicalReview 👇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Rethinking the role of position in cortical function - Nature Neuroscience Abnormally located cortical neurons, displaced in developing mice lacking cortical Eml1, retain their molecular identities, form appropriate connections and build functional sensory maps. Most strikin...

Rethinking the role of position in #cortical #function
doi.org/10.1038/s415...

Geometric principles of dendritic integration of excitation and inhibition in cortical neurons Selective activation of E and I receptors by two-color uncaging defines their geometrical interaction at the subdendritic level.

#Geometric principles of #dendritic integration of excitation and inhibition in #cortical #neurons | Science Advances www.science.org/doi/10.1126/...

Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence Mouse models of schizophrenia show defects in adolescent spine formation in a specific dendritic compartment of L5 neurons.

#Dendritic compartment-specific spine formation in layer 5 #neurons underlies #cortical #circuit maturation during adolescence | Science Advances www.science.org/doi/10.1126/...

Client Challenge

Mimicking #opioid #analgesia in #cortical #pain #circuits
doi.org/10.1038/s415...

.... effectively rewiring #neuralnetworks.

📖 As seen in this @cp-cellrepphyssci.bsky.social article: www.cell.com/cell/fulltex...

These changes were network-specific, strengthening pathways tied to perception and the brain’s default mode network, while quieting repetitive #cortical loops.

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Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mi...

#Cortical glutamatergic and GABAergic inputs support #learning -driven #hippocampal stability | Science www.science.org/doi/10.1126/...

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent cortical loops that could underlie its therapeutic effects.

#Psilocybin triggers an activity-dependent rewiring of large-scale #cortical #networks: Cell www.cell.com/cell/fulltex...

Cross-modal deep generative models reveal the cortical representation of dancing - Nature Communications Using fMRI and AI-powered computational models, researchers mapped how the brain choreographs dance—revealing precise, brain-wide patterns and clear differences between expert dancers and novices.

Cross-modal deep generative models reveal the #cortical representation of #dancing | Nature Communications

www.nature.com/articles/s41...

#MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech

Coffee and Your Brain: What MRI Scans Reveal About Optimal Consumption In today's episode we're exploring the significant association between regular coffee consumption and structural brain health, focusing on findings from the population-based Hamburg City Health Study. Researchers investigated how coffee intake relates to key brain MRI parameters, including markers of neurodegeneration (cortical thickness) and microstructural integrity (PSMD). The study indicated that moderate consumption of 1–4 cups per day was associated with better microstructural white matter integrity (lower PSMD). Furthermore, 3–4 cups per day was specifically linked to higher cortical thickness. We discuss this observed U-shaped relationship - where very high consumption was not superior to very low consumption - and the suggested neuroprotective roles of coffee's anti-inflammatory properties. Source: https://doi.org/10.3390/nu15030674 on Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study

📣 New Podcast! "Coffee and Your Brain: What MRI Scans Reveal About Optimal Consumption" on @Spreaker #aging #brain #caffeine #coffee #consumption #cortical #csvd #dementia #health #inflammation #integrity #moderate #mri #neurology #neuroprotection #psmd #study #thickness #vascular #wmh

Top: Schematic of the analytical approach for evaluating the T1w/T2w ratio across cortical regions and depths in macaques (left) and humans (right). In each case, the left panel displays the discrete parcels of CHARM level 6 for macaques and Schaefer 400 for humans. The middle panel labels the parcels based on geodesic distance for macaques or the sensorimotor-association axis for humans, with colors transitioning from yellow (sensorimotor) to purple (association). The right panel visualizes the laminar organization, with colors transitioning from deep blue (deep layers) to light green (superficial layers). Bottom: T1w/T2w ratio developmental trajectories across sensorimotor (yellow) and association (purple), regions, and across deep (dark blue) and superficial (green) cortical layers for macaques (straight) and humans (dotted). T1w/T2w values are adjusted relative to 1 year old (macaque) and 4 years old (human) as the baseline (y = 0). The age spans that overlap between macaques and humans are shown in solid colors, while the non-overlapping age span are plotted in diluted colors.

Cortical development in #primates follows a hierarchical gradient, but how does this vary between species? This study shows that #humans & #macaques share conserved maturation patterns, with humans exhibiting prolonged #cortical development @plosbiology.org 🧪 plos.io/4prEO65

Top: Schematic of the analytical approach for evaluating the T1w/T2w ratio across cortical regions and depths in macaques (left) and humans (right). In each case, the left panel displays the discrete parcels of CHARM level 6 for macaques and Schaefer 400 for humans. The middle panel labels the parcels based on geodesic distance for macaques or the sensorimotor-association axis for humans, with colors transitioning from yellow (sensorimotor) to purple (association). The right panel visualizes the laminar organization, with colors transitioning from deep blue (deep layers) to light green (superficial layers). Bottom: T1w/T2w ratio developmental trajectories across sensorimotor (yellow) and association (purple), regions, and across deep (dark blue) and superficial (green) cortical layers for macaques (straight) and humans (dotted). T1w/T2w values are adjusted relative to 1 year old (macaque) and 4 years old (human) as the baseline (y = 0). The age spans that overlap between macaques and humans are shown in solid colors, while the non-overlapping age span are plotted in diluted colors.

Cortical development in #primates follows a hierarchical gradient, but how does this vary between species? This study shows that #humans & #macaques share conserved maturation patterns, with humans exhibiting prolonged #cortical development @plosbiology.org 🧪 plos.io/4prEO65

Top: Schematic of the analytical approach for evaluating the T1w/T2w ratio across cortical regions and depths in macaques (left) and humans (right). In each case, the left panel displays the discrete parcels of CHARM level 6 for macaques and Schaefer 400 for humans. The middle panel labels the parcels based on geodesic distance for macaques or the sensorimotor-association axis for humans, with colors transitioning from yellow (sensorimotor) to purple (association). The right panel visualizes the laminar organization, with colors transitioning from deep blue (deep layers) to light green (superficial layers). Bottom: T1w/T2w ratio developmental trajectories across sensorimotor (yellow) and association (purple), regions, and across deep (dark blue) and superficial (green) cortical layers for macaques (straight) and humans (dotted). T1w/T2w values are adjusted relative to 1 year old (macaque) and 4 years old (human) as the baseline (y = 0). The age spans that overlap between macaques and humans are shown in solid colors, while the non-overlapping age span are plotted in diluted colors.

Cortical development in #primates follows a hierarchical gradient, but how does this vary between species? This study shows that #humans & #macaques share conserved maturation patterns, with humans exhibiting prolonged #cortical development @plosbiology.org 🧪 plos.io/4prEO65

How does the geometry of #NeuralDynamics on the #cortical #attractor landscape reflect changes in attention? A new preprint by Song et al. 👇 investigates this by fitting a dynamical systems model to #fMRI data.

#Neuroscience #CompNeuro 🧪

Cathepsin L plays a crucial role in the diversity and functionality of T cells An international team led by Ludger Klein has provided important insights into the maturation of T cells in the thymus, which is a central process in the development of a functioning immune system.

📣 New in @natimmunol.nature.com:
#Cathepsin L plays a crucial role in the diversity and functionality of #CD4 #Tcells

➡️ www.med.lmu.de/bmc/en/news/...

#cortical #epithelial #cells #receptor #thymus #immune #immunology #MHC #major #histocompatibility #complex #cysteine #protease

📷 J.Greune

Original post on zephyrnet.com

Scalable production of human cortical organoids using a biocompatible polymer Qian, X., Song, H. & Ming, G. L. Brain organoids: advances, applications and challenges. Development 146, dev166074...

#Drug #Discovery #biocompatible #cortical #human #organoids […]

[Original post on zephyrnet.com]

By recording #cortical #angiograms during i.v. injection of FITC-dextran 🟢 in #adult and #old #NG2DsRed mice, we time-colored the #arterioles 🔴 and #venules 🔵. We found that #OldMice have less #collaterals and more #tortuous #PenetratingArterioles.

Recent #Research by Leonardo Dalla Porta et al. examines H-current modulation of #cortical Up and Down states 🧠 🔍

📜 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

SciTech Chronicles. . . . . . . . .Mar 31st, 2025 In the beginning God created data. Then She created Man to corrupt it. Vol II No 80 167 links Curated New Copper Alloy Demonstrates Incredi...

bit.ly/stc033125

#nanostructured #Copper-Tantalum-Lithium #stability #strength #Connectome #cortical #thickness #volume #conductor #Faraday #electrostatic #tube #stromatolites #amino-acids #abiogenesis #carbon-nitrogen #AMSAT-OSCAR #AO-7 #NiCd #AE4JC

SciTech Chronicles. . . . . . . . .Mar 17th, 2025 To be led by a coward is to be controlled by all that the coward fears Vol II No 69 311 links Curated Scientists uncover surprising oral mic...

SciTech Chronicles. . . . . . . . .Mar 17th, 2025

bit.ly/stc031725

#dementia #nitrate #Porphyromonas #Neisseria #Lookup #Registration #IETF #gTLD #MIMO #FPA #MRA #SQP #wildfires #mesh #Kinéis #Silvanet #cortical #amygdala #neurobiology #ESR1

New Artist announced for Rewire Festival 2025: 🔥 Cortical 🔥

🎶 Listen to the current LineUp on YouTube and Spotify
🎟️ Get your Tickets now

#Rewire_Festival_2025 #Cortical #fyre_festivals #livemusic #youtube #spotify #music #musicfestivals #playlist #tickets #announcement

#Glioblastoma #Cortical #Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer #precisionOncology #PDO

scRNAseq revealing endogenous #malignant #transcripts transfer #EV from malignant to nonmalignant cells, toward #GBM cell states + #astroglia cell types!

tinyurl.com/5h2v8tak