New research article

Microbiological analysis and whole-genome sequencing of #Neisseria gonorrhoeae from the microbiological failures in the … #zoliflodacin … trial for treatment of uncomplicated urogenital #gonorrhoea

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #STI #AMR #OpenAccess #OA

New research article

Antimicrobial resistance in bacterial #meningitis caused by #Streptococcus pneumoniae, #Neisseria meningitidis, or #Haemophilus influenzae (2010–24): a systematic review and meta-analysis

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #AMR #OpenAccess #OA

December cover of The Lancet Microbe

Our December issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #Bordetela #pertussis #scabies #Neisseria #Chlamydia #HIV #TB #AMR #phage #Mycoplasma #Ebola

#IDSky #ClinMicro #OA

FDA approves first new kind of drug to target gonorrhea in decades The bacterium that causes gonorrhea has developed resistance to nearly every antibiotic used against it.

First new kind of #drug to target #gonorrhea in decades approved ...

| #infection | #STI | #antibioticresistance | #Neisseria | #bacteria | By @helenbranswell.bsky.social via @statnews.com

🔬Vaccine innovation against #AMR

BactiVac's funded 115 projects targeting key AMR-relevant pathogens: #Klebsiella #Ecoli #Salmonella #Shigella #Neisseria, #Pseudomonas #Pneumococcus #Staphylococcus & #Streptococcus

#WAAW @wellcometrust.bsky.social @britsocimm.bsky.social @microbiologysociety.org

Cover of the November issue of The Lancet Microbe

Our November issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #HTLV-1 #AMR #Lassa #Neisseria #gonorrhoea #tuberculosis #TB #influenza

#IDSky #ClinMicro #OA

New research article

Effect of decreasing the frequency of screening for #Neisseria gonorrhoeae and #Chlamydia trachomatis on the incidence of these infections and antimicrobial use among men who have sex with men using #HIV #PrEP in Belgium

www.thelancet.com/journals/lan...

#AMR #OpenAccess #OA

3 scary complications of gonorrhea Here’s what gonorrhea is, how it spreads and how it is treated if it affects you or someone you love.

Scary complications of #gonorrhea ...

| #infection | #Neisseria | #bacteria | #pathogen | #STI | Via @usatoday.com

New research article

Determining targets for #ceftriaxone resistance detection in #Neisseria gonorrhoeae based on genotype–phenotype data: an observational study

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #AMR #gonorrhoea #gonorrhea #OpenAccess #OA

#Medicine #cellculture #bacteria #neisseria

AI has produced 2 new antibiotics to kill ‘superbugs’. It’s promising – but we shouldn’t get too excited yet This is a significant scientific development, but several hurdles remain before we might see these antibiotics available for use.

#AI producing #antibiotics is promising – but we should NOT get too excited yet ...

| #bacteria | #antibioticresistance | #superbug | #Neisseria | #Staphylococcus | Via @theconversation.com

Condoms, PrEP and vaccines: how the UK is expanding STI prevention Targeted vaccines and antiviral prophylaxis are expanding prevention options and redefining ‘safe sex’ for gay, bisexual and other men who have sex with men.

#Condoms, #PrEP and #vaccines .. expanding #STI prevention ...

| #gonorrhoea | #STD | #UnitedKingdom | #Neisseria | #bacteria | #infections | Via @theconversation.com

New research article

Selecting candidate #Neisseria gonorrhoeae strains for oropharyngeal #gonorrhoea human challenge: a genomics-based analysis of clinical isolates

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #MicroSky #CHIM #OpenAccess #OA

Alaskan Woman’s Death From Gonorrhea Sparks Fears of a New Strain A woman in her 50s died from a rare complication of the bacterial STI this spring, the latest in a recent spike of similar cases in the state.

Alaskan Woman’s death from #gonorrhea sparks fears of a new strain ...

| #bacteria | #STI | #Neisseria | #infection | By @edcara.bsky.social via @gizmodo.com

New cases of meningococcal disease have been detected. What are the symptoms? And who can get vaccinated? Meningococcal disease is a rare but life-threatening illness caused by the bacteria Neisseria meningitidis.

New incidences of #meningococcal #disease have been detected ...

| #bacteria | #Neisseria | #vaccination | #infection | Via @theconversation.com‬

Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by #Neisseria gonorrhoeae via effects on sialic acid metabolism.

Ng exploits type I IFNs to sialylate LOS and evade immunity; blocking IFNs aids bacterial clearance.

www.cell.com/cell-host-mi... #MicroSky

Cover of The Lancet Microbe's April issue with a "Coloured transmission electron micrograph of Neisseria lactamica undergoing mitotic division".

Our April issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #COVID-19 #chikungunya #Neisseria #CHIM #mpox #BSI #Ecoli #Klebsiella #Mycoplasma

#IDSky #ClinMicro #OA

SciTech Chronicles. . . . . . . . .Mar 17th, 2025 To be led by a coward is to be controlled by all that the coward fears Vol II No 69 311 links Curated Scientists uncover surprising oral mic...

SciTech Chronicles. . . . . . . . .Mar 17th, 2025

bit.ly/stc031725

#dementia #nitrate #Porphyromonas #Neisseria #Lookup #Registration #IETF #gTLD #MIMO #FPA #MRA #SQP #wildfires #mesh #Kinéis #Silvanet #cortical #amygdala #neurobiology #ESR1

Some very impressive work on #Neisseria #gonorrhoeae

New research article

Controlled human infection model of #Neisseria lactamica in late pregnancy investigating mother-to-infant transmission in the UK: a single-arm pilot trial

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#IDSky #ClinMicro #OpenAccess #OA

Top: Organisation of the nap island in Neisseria gonorrhoeae FA1090. Grey arrows, flanking genes (NEIS0808, pseudouridine synthase; NEIS0794, histidyl-tRNA synthase); blue arrows, genes coding for GG-containing peptides; orange arrows, genes predicted to be involved in peptide processing and secretion; green arrow, gene of unknown function; pink boxes, Correia elements. Bottom: Transmission electron microscopy images from bacteria in HEPES (T = 75 min). Some wild-type bacteria appear normal (indicated with arrow numbered 1), with many others having a dense (arrow 2) or very dense (arrow 3) cytoplasm, periplasmic expansions (arrow 4), or appearing as ghost cells (arrow 5). Extracellular vesicles (arrow 6) and released cellular content (arrow 7) are also visible. Periplasmic expansions are not observable in the ΔltgA or ΔnapRABC strains. Cytoplasm condensation appears more homogenous in the ΔltgA mutant.

Programmed cell death distinguishes N. gonorrhoeae & N. meningitidis from other #Neisseria species. @katyponcin.bsky.social &co identify a horizontally acquired genetic island encoding peptides that drive #autolysis & human cell lysis, aiding colonization & disease 🧪 @plosbiology.org plos.io/4aP2om9

Top: Organisation of the nap island in Neisseria gonorrhoeae FA1090. Grey arrows, flanking genes (NEIS0808, pseudouridine synthase; NEIS0794, histidyl-tRNA synthase); blue arrows, genes coding for GG-containing peptides; orange arrows, genes predicted to be involved in peptide processing and secretion; green arrow, gene of unknown function; pink boxes, Correia elements. Bottom: Transmission electron microscopy images from bacteria in HEPES (T = 75 min). Some wild-type bacteria appear normal (indicated with arrow numbered 1), with many others having a dense (arrow 2) or very dense (arrow 3) cytoplasm, periplasmic expansions (arrow 4), or appearing as ghost cells (arrow 5). Extracellular vesicles (arrow 6) and released cellular content (arrow 7) are also visible. Periplasmic expansions are not observable in the ΔltgA or ΔnapRABC strains. Cytoplasm condensation appears more homogenous in the ΔltgA mutant.

Programmed cell death distinguishes N. gonorrhoeae & N. meningitidis from other #Neisseria species. @katyponcin.bsky.social &co identify a horizontally acquired genetic island encoding peptides that drive #autolysis & human cell lysis, aiding colonization & disease 🧪 @plosbiology.org plos.io/4aP2om9

Top: Organisation of the nap island in Neisseria gonorrhoeae FA1090. Grey arrows, flanking genes (NEIS0808, pseudouridine synthase; NEIS0794, histidyl-tRNA synthase); blue arrows, genes coding for GG-containing peptides; orange arrows, genes predicted to be involved in peptide processing and secretion; green arrow, gene of unknown function; pink boxes, Correia elements. Bottom: Transmission electron microscopy images from bacteria in HEPES (T = 75 min). Some wild-type bacteria appear normal (indicated with arrow numbered 1), with many others having a dense (arrow 2) or very dense (arrow 3) cytoplasm, periplasmic expansions (arrow 4), or appearing as ghost cells (arrow 5). Extracellular vesicles (arrow 6) and released cellular content (arrow 7) are also visible. Periplasmic expansions are not observable in the ΔltgA or ΔnapRABC strains. Cytoplasm condensation appears more homogenous in the ΔltgA mutant.

Programmed cell death distinguishes N. gonorrhoeae & N. meningitidis from other #Neisseria species. @katyponcin.bsky.social &co identify a horizontally acquired genetic island encoding peptides that drive #autolysis & human cell lysis, aiding colonization & disease 🧪 @plosbiology.org plos.io/4aP2om9

Pilin variants segregated in mixed microcolonies. wt*red (Ng170) were mixed at a 1:1 ratio with (in rows 1-5) wtpilE24 green (Ng309), wtpilE17 green (Ng308), wtpilE32 green (Ng310), ΔpilEgreen (Ng081), wt*green (Ng105). Scale bar: 10 μm.

#Neisseria gonorrhoeae evades immunity by altering its surface structures. @maierlab.bsky.social &co show that this process also modulates bacterial interactions, driving microcolony diversification, aggregation, colony morphology & #antibiotic tolerance 🧪 @plosbiology.org plos.io/4aN1zdO

Pilin variants segregated in mixed microcolonies. wt*red (Ng170) were mixed at a 1:1 ratio with (in rows 1-5) wtpilE24 green (Ng309), wtpilE17 green (Ng308), wtpilE32 green (Ng310), ΔpilEgreen (Ng081), wt*green (Ng105). Scale bar: 10 μm.

#Neisseria gonorrhoeae evades immunity by altering its surface structures. @maierlab.bsky.social &co show that this process also modulates bacterial interactions, driving microcolony diversification, aggregation, colony morphology & #antibiotic tolerance 🧪 @plosbiology.org plos.io/4aN1zdO

Pilin variants segregated in mixed microcolonies. wt*red (Ng170) were mixed at a 1:1 ratio with (in rows 1-5) wtpilE24 green (Ng309), wtpilE17 green (Ng308), wtpilE32 green (Ng310), ΔpilEgreen (Ng081), wt*green (Ng105). Scale bar: 10 μm.

#Neisseria gonorrhoeae evades immunity by altering its surface structures. @maierlab.bsky.social &co show that this process also modulates bacterial interactions, driving microcolony diversification, aggregation, colony morphology & #antibiotic tolerance 🧪 @plosbiology.org plos.io/4aN1zdO

Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and APOE4 genotype Abstract. Apolipoprotein E4 (APOE4) genotype and nitric oxide (NO) deficiency are risk factors for age-associated cognitive decline. The oral microbiome pl

Oral #microbiome: #Neisseria → supports #cognitive functions. Porphyromonas predicts decline. Nitrate-rich #diet →beneficial oral bacteria →↑ cognitive outcomes. Prevotella assoc. w #APOE4 allele. [open access] bit.ly/4aBIQll bit.ly/3Ebg0Mj

New research article in The Lancet Microbe

Antimicrobial-resistant #Neisseria gonorrhoeae in Europe in 2020 compared with in 2013 and 2018: a retrospective genomic surveillance study

www.thelancet.com/journals/lan...

#gonorrhoea #gonorrhea #STI #AMR #MicroSky #IDSky #OpenAccess #OA

New research article in The Lancet Microbe

Anorectal #Neisseria gonorrhoeae infections in women with and without reported anal sex and sex workers in sexual health centres in the Netherlands: a retrospective cohort study thelancet.com/journals/lan...

#gonorrhoea #STIs