ESR1 Expression Negatively Correlates with Immune Cell Infiltration and Response to Immune Checkpoint Inhibitors in Estrogen Receptor-Positive/HER2-Negative Breast Cancer - PubMed High ESR1 expression was associated with an immunosuppressive TME in ER+/HER2- BC and is a more robust predictive biomarker for ICI response in this BC subtype.

Yet another explanation why HR+/HER2- breast cancer does not respond well to immune checkpoint inhibitors.

#cancer #oncology #pembrolizumab #esr1

pubmed.ncbi.nlm.nih.gov/40956534/

Dr. Erika Hamilton on VERITAC-2: Vepdegestrant Shows PFS Benefit in ESR1m ER+/HER2- Breast Cancer | Docwire News Vepdegestrant improves PFS in ESR1-mutant ER+/HER2- breast cancer, offering a well-tolerated oral option post-CDK4/6.

New data from VERITAC-2:
@erikahamilton9.bsky.social
discusses how the oral PROTAC degrader vepdegestrant stacks up against fulvestrant in ESR1-mutated, ER+/HER2– metastatic breast cancer. Watch the interview: docwirenews.com/post/dr-erik... #ASCO25 #BreastCancer #ESR1 #bcsm ‪@scri.com‬

@ASCO

Early camizestrant therapy keeps advanced breast cancer in check Switching to camizestrant, a next-generation oral SERD, significantly prolongs progression-free survival and maintains quality of life in patients with ESR1-mutated, hormone receptor-positive advanced...

Early camizestrant therapy keeps advanced breast cancer in check www.news-medical.net/news/2025060... #breastcancer #oncology #camizestrant #SERD #ESR1 #clinicaltrial @nejm.org

Are serial liquid biopsies finally ready for prime time?

If #camizestrant is approved based on #SERENA-6, it would mark the first therapy triggered by a rising #ESR1 mutation before visible recurrence.

That means #ctDNA won’t just monitor—it could guide treatment.

@ascocancer.bsky.social
#bcsm

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

#BreastCancer #PIK3CA #ESR1 #Elacestrant #MedSky #OncSky

SciTech Chronicles. . . . . . . . .Mar 17th, 2025 To be led by a coward is to be controlled by all that the coward fears Vol II No 69 311 links Curated Scientists uncover surprising oral mic...

SciTech Chronicles. . . . . . . . .Mar 17th, 2025

bit.ly/stc031725

#dementia #nitrate #Porphyromonas #Neisseria #Lookup #Registration #IETF #gTLD #MIMO #FPA #MRA #SQP #wildfires #mesh #Kinéis #Silvanet #cortical #amygdala #neurobiology #ESR1

#EMBER3 takeaways:

imlunestrant 🔼 PFS in patients with #ESR1 mut #MBC (5.5 vs. 3.8 mo)

Combination with abemaciclib further 🔼 PFS regardless of ESR1 and PIK3CA #ctDNA status (9.4 vs. 5.5 mo)

Previous CDK4/6i were mainly Palbo and Ribo in the MBC setting

#SABCS24 #bcsm #BreastCancer

Bio-Techne Introduces Advanced ESR1 Mutation Monitoring Assay for Breast Cancer Treatment Insights Bio-Techne's new ESR1 mutation monitoring assay offers high sensitivity for detecting mutations linked to hormone receptor-positive metastatic breast cancer.

Bio-Techne Introduces Advanced ESR1 Mutation Monitoring Assay for Breast Cancer Treatment Insights #United_States #Minneapolis #Bio-Techne #ESR1 #Asuragen